Influence of vitamin B<sub>6</sub> supplementation on polyunsaturated fatty acids concentration in serum and liver of rats fed a diet restricted in protein

Bertrandt, Jerzy; Kłos, Anna; Debski, Bogdan

doi:10.1002/food.200300338

Cited by 9 publications

(11 citation statements)

References 33 publications

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“…Witten and Holman [13] observed a decrease of arachidonic acid concentration in tissues of rats fed B 6 deficient diet and Goswami and Coniglio [1] found that deficient of vitamin B 6 simultaneous decreased of LA and increased of another PUFAs concentration in rat's testis. In malnutrition of rats obtained by restriction of the adequate diet consumption up to 50% and 30% daily consumption the vitamin B 6 addition caused significant changes of PUFAs in blood serum and liver [5].…”

Section: Resultsmentioning

confidence: 98%

Content of polyunsaturated fatty acids (PUFAs) in serum and liver of rats fed restricted diets supplemented with vitamins B2, B6 and folic acid

2004

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The aim of study was to investigate an influence of nutritional deficiency and dietary addition of vit. B(2), B(6) and folic acid on PUFAs content in rats' serum and liver. Limitation of consumption full value diet to 50% of its previously determined daily consumption, enriched with m/a vitamins, significant decreased of linoleic (LA) and alpha-linolenic (ALA) acids as well as distinctly increased arachidonic (AA) and docosahexaenoic (DHA) acids content in serum in 30th day. In 60th day lower content of AA and DHA fatty acids was found. Nutrition with such diet, lasting 90 days caused decrease of LA content and increase of AA. Diet limitation to its 30% of daily consumption decreased of eicosapentaenoic acid (EPA) and DHA in the 30th day, while AA and DHA content was increased in the 60th day. Distinct decrease of AA content and increase of EPA content were found in the 90th day of experiment. Use of diets, with limited consumption to 50% caused increase of LA and ALA acids content while AA and DHA acids content were significantly decreased in the liver, in 90th day. Limited consumption supplemented diet to 30% caused in liver significant decrease of LA and increase of EPA acids content.

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Section: Resultsmentioning

confidence: 98%

Content of polyunsaturated fatty acids (PUFAs) in serum and liver of rats fed restricted diets supplemented with vitamins B2, B6 and folic acid

2004

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“…The PDXDC1 protein, a vitamin B6-dependent decarboxylase, is expressed preferentially in the intestine [44], but its function is not known. Animal studies support an influence of dietary vitamin B6 (pyridoxal) on serum and liver levels of ALA and other PUFAs [45], [46], which has been interpreted as an effect on desaturase enzymes activity. The association of PDXDC1 with ALA, if confirmed in other studies, raises the possibility of another vitamin B6-dependent protein affecting ALA, for example through involvement in intestinal ALA absorption.…”

Section: Discussionmentioning

confidence: 97%

Genetic Loci Associated with Plasma Phospholipid n-3 Fatty Acids: A Meta-Analysis of Genome-Wide Association Studies from the CHARGE Consortium

et al. 2011

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Long-chain n-3 polyunsaturated fatty acids (PUFAs) can derive from diet or from α-linolenic acid (ALA) by elongation and desaturation. We investigated the association of common genetic variation with plasma phospholipid levels of the four major n-3 PUFAs by performing genome-wide association studies in five population-based cohorts comprising 8,866 subjects of European ancestry. Minor alleles of SNPs in FADS1 and FADS2 (desaturases) were associated with higher levels of ALA (p = 3×10−64) and lower levels of eicosapentaenoic acid (EPA, p = 5×10−58) and docosapentaenoic acid (DPA, p = 4×10−154). Minor alleles of SNPs in ELOVL2 (elongase) were associated with higher EPA (p = 2×10−12) and DPA (p = 1×10−43) and lower docosahexaenoic acid (DHA, p = 1×10−15). In addition to genes in the n-3 pathway, we identified a novel association of DPA with several SNPs in GCKR (glucokinase regulator, p = 1×10−8). We observed a weaker association between ALA and EPA among carriers of the minor allele of a representative SNP in FADS2 (rs1535), suggesting a lower rate of ALA-to-EPA conversion in these subjects. In samples of African, Chinese, and Hispanic ancestry, associations of n-3 PUFAs were similar with a representative SNP in FADS1 but less consistent with a representative SNP in ELOVL2. Our findings show that common variation in n-3 metabolic pathway genes and in GCKR influences plasma phospholipid levels of n-3 PUFAs in populations of European ancestry and, for FADS1, in other ancestries.

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“…Also in rats fed PR diet during pregnancy, alteration of membrane fatty acid content and composition in the offspring were noticed (Burdge et al., 2003). In a previous experiment, we have shown that addition of vitamin B 6 to low protein diet caused an increase in PUFAs particularly alpha‐linolenic and docosahexoenoic acid in serum of rats (Bertrandt et al., 2004). This vitamin in the form of pirydoxal phosphate participates in lipid metabolism, mainly in PUFAs desaturation (Bordoni et al., 1998).…”

Section: Discussionmentioning

confidence: 99%

The Influence of Folic Acid, Vitamins B₂ and B₆ Supplementation on Feed Intake, Body and Organs Weight, and Liver Fatty Acids Composition of Rats Subjected to 3 months Moderate Protein Deprivation

Debski¹,

Bertrandt

Kłos

et al. 2007

Journal of Veterinary Medicine Series A

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This study was conducted to determine the effect of a 3-month dietary protein restriction - protein provided 9% of energy (20% in control group). In this dietary restriction folic acid, vitamins B(2) and B(6) were delivered in amount three times above the standard level. It was observed that animals fed a protein restricted (PR) diet weighed about 5% less than animals consuming adequate diet, but the difference was not statistically significant. Enrichment of PR diet with vitamin B or folic acid caused tendency to further suppression of weight gain, and in case of vitamin B(6) these differences were statistically significant. However, such body weight (BW) suppression was not observed when all studied vitamins were used together. Significant reductions in relative liver weight (vitamin B(2) addition), the heart (folic acid) and the lungs (vitamin B(6)) were observed. The PR diet, when all vitamins were added together, caused a decrease in weights of the lungs, heart and liver scaled to BW of rats, simultaneously with a significant increase in testis weight. Feed intake and feed conversion ratio were higher in animals given PR diet without a significant influence of vitamin supplementation (except vitamin B(6) causing further increase in feed conversion ratio). Hepatic fatty acids composition of rats was not affected by protein restriction, as well as by single vitamin supplementation. However, dietary supplementation of all examined vitamins together caused a decrease in monounsaturated fatty acids followed by an increase in polyunsaturated fatty acids participation in total fatty acids pool. It seems that enrichment of PR diet with a mixture of folic acid, vitamins B(2) and B(6) resulted in a partial reverse of growth suppression and reduction in testis size in rats.

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Influence of vitamin B₆ supplementation on polyunsaturated fatty acids concentration in serum and liver of rats fed a diet restricted in protein

Cited by 9 publications

References 33 publications

Content of polyunsaturated fatty acids (PUFAs) in serum and liver of rats fed restricted diets supplemented with vitamins B2, B6 and folic acid

Content of polyunsaturated fatty acids (PUFAs) in serum and liver of rats fed restricted diets supplemented with vitamins B2, B6 and folic acid

Genetic Loci Associated with Plasma Phospholipid n-3 Fatty Acids: A Meta-Analysis of Genome-Wide Association Studies from the CHARGE Consortium

The Influence of Folic Acid, Vitamins B₂ and B₆ Supplementation on Feed Intake, Body and Organs Weight, and Liver Fatty Acids Composition of Rats Subjected to 3 months Moderate Protein Deprivation

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Influence of vitamin B6 supplementation on polyunsaturated fatty acids concentration in serum and liver of rats fed a diet restricted in protein

Cited by 9 publications

References 33 publications

Content of polyunsaturated fatty acids (PUFAs) in serum and liver of rats fed restricted diets supplemented with vitamins B2, B6 and folic acid

Content of polyunsaturated fatty acids (PUFAs) in serum and liver of rats fed restricted diets supplemented with vitamins B2, B6 and folic acid

Genetic Loci Associated with Plasma Phospholipid n-3 Fatty Acids: A Meta-Analysis of Genome-Wide Association Studies from the CHARGE Consortium

The Influence of Folic Acid, Vitamins B2 and B6 Supplementation on Feed Intake, Body and Organs Weight, and Liver Fatty Acids Composition of Rats Subjected to 3 months Moderate Protein Deprivation

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Influence of vitamin B₆ supplementation on polyunsaturated fatty acids concentration in serum and liver of rats fed a diet restricted in protein

The Influence of Folic Acid, Vitamins B₂ and B₆ Supplementation on Feed Intake, Body and Organs Weight, and Liver Fatty Acids Composition of Rats Subjected to 3 months Moderate Protein Deprivation