Influence of ventricular morphology on aerobic exercise capacity in patients after the Fontan operation

Abstract

In addition to AVVR, hypoxia, and heart rate response, ventricular morphology is related to exercise capacity. Early Fontan operation may be beneficial in terms of exercise capacity, especially in the group RV patients.

Abnormalities of Neurohormonal and Cardiac Autonomic Nervous Activities Relate Poorly to Functional Status in Fontan Patients

“…Our control subjects showed no significant stenotic lesions of the coronary arteries. 1,5 Postoperative Status Based on New York Heart Association Classification…”

“…We estimated oxygen consumption from the age, sex, and heart rate (HR) and measured cardiac index (L · min Ϫ1 · m Ϫ2 ) using the Fick principle with the assumption that right and left pulmonary arterial saturations were equal in patients with either a Glenn anastomosis or a TCPC, because it is clinically difficult to measure accurate flow distribution of the bilateral pulmonary arteries. Ventricular morphology was determined angiographically, and patients were divided into 3 groups, 1 ie, those with (1) a dominant left ventricle with or without a rudimentary right ventricle, (2) presence of both right and left ventricles, and (3) a dominant right ventricle with or without a rudimentary left ventricle. In this study, the groups consisted of 43, 19, and 35 patients, respectively.…”

“…Patients with 2 ventricles in whom the volume of the smaller ventricle was either Ͼ30% of the main ventricle or was Ͼ50% of the predicted normal value were included in the biventricular group. 1 We used Simpson's rule to estimate morphological right and left ventricular volumes. End-diastolic ventricular volume was divided by body surface area to obtain end-diastolic volume index (EDVI), and systemic ventricular ejection fraction (EF) was calculated.…”

“…End-diastolic ventricular volume was divided by body surface area to obtain end-diastolic volume index (EDVI), and systemic ventricular ejection fraction (EF) was calculated. 1,5 …”

“…[1][2][3][4] These changes resemble those in adult patients with chronic heart failure (CHF) and NHA and CANA have been useful in stratifying these adult CHF patients and predicting their prognosis. [5][6][7][8][9][10] These 2 indices are also, to some extent, applicable to postoperative patients with congenital heart disease after biventricular repair, especially in adult patients.…”