Influence of Vasopressin on Learning and Memory

Jj, Legros; Gilot, P; Serón, Xavier; Claessens, Jan; Adam, Alejandro P.; Moeglen, J.M; Audibert, Agnès; Berchier, P

doi:10.1016/s0140-6736(78)90386-0

Cited by 222 publications

(45 citation statements)

References 3 publications

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“…It is also significant that there was no difference in the response to the challenge dose of morphine between the placebo-implanted mice of either strain that had received the peptide and the placebo-implanted mice that received the vehicle injections (P > 0.01). hormones as well as certain of their derivatives and fragments have been shown to alter memory and physical dependence upon and tolerance to morphine (1)(2)(3)(4)(5)(6)(7)(8)(9)(10).…”

Section: Methodsmentioning

confidence: 99%

“…Several of these peptides, notably vasopressin and its analogs, can modify various aspects of behavior including acquisition and extinction of conditioned responses in lower species as well as of memory in man (4)(5)(6)(7)(8)(9)(10). In addition, non-disulfide-containing linear hormone fragments, such as Pro-Leu-Gly-NH2 (melanotropin-release inhibiting factor) (11), Z-Pro-Leu-Gly-NH2 (7), the enzymatically stable cyclo(LeuGly) (12), and Pro-Arg-Gly-NH2 (13) also exhibit these effects (7,8,13).…”

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confidence: 99%

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Inhibition by Z-Pro-D-Leu of development of tolerance to and physical dependence on morphine in mice.

Walter¹,

Ritzmann²,

Bhargava³

et al. 1978

Proc. Natl. Acad. Sci. U.S.A.

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The peptide Z-Pro-D-Leu, injected daily in mice receiving morphine chronically, was found to prevent development of physical dependence as measured by changes in body temperature and body weight due either to abrupt or to naloxone-induced withdrawal. On the other hand, administration of Z-Pro-D-Leu only on the last day of morphine treatment did not alter the overt signs of withdrawal. Daily administration of Z-Pro-D-Leu was also effective in blocking the development of tolerance to the analgesic and the hypothermic effects of subsequent challenge doses of morphine. However, the peptide treatment did not alter the acute effects of a challenge dose of morphine on either analgesia or body temperature. No effects on memory were noted, as evaluated in a one-trial passive avoidance task. Clinical implications of the use of Z-Pro-D-Leu are discussed.Certain neurohypophyseal hormones, their analogs, and disulfide-containing cyclic fragments of these hormones facilitate development of physical dependence on and tolerance to actions of morphine (1-3). Several of these peptides, notably vasopressin and its analogs, can modify various aspects of behavior including acquisition and extinction of conditioned responses in lower species as well as of memory in man (4-10). In addition, non-disulfide-containing linear hormone fragments, such as Pro-Leu-Gly-NH2 (melanotropin-release inhibiting factor) (11), Z-Pro-Leu-Gly-NH2 (7), the enzymatically stable cyclo(LeuGly) (12), and Pro-Arg-Gly-NH2 (13) also exhibit these effects (7,8,13).Recently, in comparing the relative potencies of these peptides in facilitating the development of physical dependence on and tolerance to morphine, van Ree and de Wied (3) found not only that oxytocin and 8-arginine vasotocin are more effective than 8-arginine vasopressin but, moreover, that ProLeu-Gly-NH2 and cyclo(Leu-Gly) are as effective as oxytocin in these tests.Replacement of an L residue in a peptide hormone or agonistic analog by the D isomer has been reported to produce, in certain instances, a competitive inhibitor or partial agonist-findings that might be explained by steric misplacement of an "active element" (14) from its preferred orientation in the "active site" (15) such that intrinsic activity is decreased or even lost with retention of receptor affinity (14, 16).On the basis of this background it was decided, as a first step in a series of studies, to evaluate the effect of Z-Pro-D-Leu on the development of physical dependence on and tolerance to morphine. MATERIALS AND METHODSThe Z-Pro-D-Leu (17) used was prepared in these laboratories (18). Male C57BL/6J, Swiss Webster, and ICR mice weighing 26 ± 4 g (±SD) were used in these studies.Mice were randomly divided into two groups. One group received subcutaneous injections of water (vehicle); the other group received Z-Pro-D-Leu (50 ,jg per mouse on day 1). Two hours later, the mice were then further subdivided and each subgroup was implanted with placebo or morphine pellets. The injections of vehicle and Z-Pro-D-Leu were repe...

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Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

Inhibition by Z-Pro-D-Leu of development of tolerance to and physical dependence on morphine in mice.

Walter¹,

Ritzmann²,

Bhargava³

et al. 1978

Proc. Natl. Acad. Sci. U.S.A.

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“…As for V, Le Beouf et al (11] and Oliveros et al [ 12] reported memory improvement in 1 patient with Korsakoffs syndrome and 3 posttraumatic and 1 alcoholic amnesic patients. Le Gros et al [ 13] reported favorable effects of V on memory performance in 12 senescent nonamnesic subjects. Gold et al [14] ob served memory improvement in 4 depressive patients treated with DDAVP, a synthetic analogue of V. The same drug was unsuccess ful in the treatment of posttraumatic amnesic patients [15][16][17], Lastly, Blake et al [18] did not obtain favorable effects with V on mem ory performance in 2 patients with Korsakoffs syndrome.…”

Section: Resultsmentioning

confidence: 99%

Vasopressin and Physostigmine in the Treatment of Amnesia

et al. 1982

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We planned a double-blind cross-over study of memory processes in patients with common types of amnesia after administration of vasopressin, physostigmine and placebo in order to validate the possible role of these drugs in the treatment of organic amnesia. Memory, learning, vigilance, attention and concentration were tested in 24 organic amnesic patients after the three treatments. No statistically significant differences among the treatments were found.

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“…Elderly patients given lysine vasopressin (by nasal spray) performed better than indi viduals treated with placebo in tests involving attention, concentration, and memory [Legros et al, 1978[Legros et al, , 1983. It should be noted that their subjects were a group of elderly persons who were not specifically screened for the presence of preexisting cognitive decline.…”

Section: Neuropeptidesmentioning

confidence: 99%

Drug Influences on Learning and Memory in Aged Animals and Humans

Hock¹

1987

Neuropsychobiology

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In this article the effects of neurotransmitter systems or specific drugs on cognitive functions of aged animals and humans are reviewed. While there have been used many different pharmacologic and behavioral approaches to treat and test cognitive deficits in aged animals and geriatric or demented patients, there is still the question of the validity of animal models of human disorders. Attempts are made to show that there are parallels and similarities. These similarities suggest that the neurological and neurochemical changes observed may play common roles in similar behavioral deficits observed in aged animals and humans.

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Influence of Vasopressin on Learning and Memory

Cited by 222 publications

References 3 publications

Inhibition by Z-Pro-D-Leu of development of tolerance to and physical dependence on morphine in mice.

Inhibition by Z-Pro-D-Leu of development of tolerance to and physical dependence on morphine in mice.

Vasopressin and Physostigmine in the Treatment of Amnesia

Drug Influences on Learning and Memory in Aged Animals and Humans

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