Influence of vascular enhancement, age and gender on pulmonary perfused blood volume quantified by dual-energy-CTPA

Meinel, Felix G.; Graef, Anita; Sommer, Wieland H.; Thierfelder, Kolja M.; Reiser, Maximilian; Johnson, Thorsten R. C.

doi:10.1016/j.ejrad.2013.04.019

Cited by 21 publications

(20 citation statements)

References 12 publications

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“…The difference in lung T1 at inspiration and expiration may thus be attributed to differences in pulmonary blood volume. Moreover, there is also substantial evidence that pulmonary blood volume decreases with age, which, in light of the previously mentioned findings, would explain the observed decrease in lung T1 with age in our study. The underlying explanation for the age dependency of pulmonary blood volume may in turn be attributed to the age dependent loss of elastic recoil in the lung; leading to closure of small airways at larger lung volumes and a corresponding increase in RV with age.…”

Section: Discussionsupporting

confidence: 86%

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Influence of age and sex on the longitudinal relaxation time, T1, of the lung in healthy never‐smokers

Kindvall

Diaz

Svensson

et al. 2015

Magnetic Resonance Imaging

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Purpose: As several studies have provided evidence that lung disease affects the T1 of the human lung, our purpose was to investigate the effect of age on the T1-relaxation time in the lungs of healthy never-smokers, including group difference between sexes. Materials and methods: The Snapshot FLASH pulse sequence (inversion recovery with multiple gradient echo read-outs) was used to quantify lung T1 in 30 healthy neversmoking volunteers at 1.5 Tesla. Measurements were performed under breath hold of a tidal inspiration. Additionally, subjects underwent clinical MRI and pulmonary function tests. A linear regression model of T1 as a function of age and sex was tested. Results: The slope of lung T1 at tidal end-inspiration as a function of age was statistically different between males and females (p<0.001). In a linear regression model of T1 as a function of age and sex, females have slope of -4.1 ms/year (95% CI= [-5.2,-3.0]) at p < 0.001, and males -0.064 ms/year (95% CI=[-1.2,1.1]) at p=0.9, with a whole model R 2 = 0.83. Conclusion:The observed dependencies of lung T1 on age and sex are here attributed to a previously reported difference in blood T1 between sexes, and a previously reported decrease of pulmonary blood volume with increasing age. This may have implications for the interpretation of lung T1 measurements in both healthy individuals and patients.

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Section: Discussionsupporting

confidence: 86%

“…A dependence of lung T1 on pulmonary blood volume would have consequences for the interpretation of measurements in patients, as pulmonary blood volume shows regional abnormalities in patients with interstitial lung disease, acute and chronic pulmonary edema, and emphysema …”

Section: Discussionmentioning

confidence: 99%

Influence of age and sex on the longitudinal relaxation time, T1, of the lung in healthy never‐smokers

Kindvall

Diaz

Svensson

et al. 2015

Magnetic Resonance Imaging

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“…This strategy was inspired by dual‐energy computed tomography (DECT), where a map of the iodine concentration is calculated after administration of iodine‐based contrast agent . A DECT acquisition is limited to a single or only a few timeframes, so that the timing of the acquisition is important, since the maximal contrast between normal and affected lung tissue occurs at the time of peak pulmonary enhancement. Compared to DECT, the timing of the DCE acquisition is much less critical, since images can be acquired continuously.…”

Section: Discussionmentioning

confidence: 99%

“…For this purpose, lung scintigraphy has long been used for imaging of patients with suspected PE . More recently, dual‐energy CT has been proposed for this purpose . Both methods have the drawback that the patient is exposed to ionizing radiation.…”

mentioning

confidence: 99%

“…8 More recently, dual-energy CT has been proposed for this purpose. [10][11][12][13] Both methods have the drawback that the patient is exposed to ionizing radiation. A recently proposed method, Fourier decomposition MRI, allows imaging of pulmonary ventilation and perfusion during free breathing without the application of contrast agent, and has been shown to be useful for the diagnosis of chronic PE without the use of ionizing radiation.…”

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confidence: 99%

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Detection of pulmonary embolism with free-breathing dynamic contrast-enhanced MRI

Ingrisch

Maxien

Meinel³

et al. 2015

J. Magn. Reson. Imaging

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Crucial considerations: Sex differences in the epidemiology, diagnosis, treatment, and outcomes of acute pulmonary embolism in non‐pregnant adult patients

et al. 2021

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Acute pulmonary embolism (PE) affects over 600,000 Americans per year and is a common diagnostic consideration among emergency department patients. Although there are well-documented differences in the diagnosis, treatment, and outcomes of cardiovascular conditions, such as ischemic heart disease and stroke, the influence of sex and gender on PE remains poorly understood. The overall age-adjusted incidence of PE is similar in women and men, but women have higher relative rates of PE during early and mid-adulthood (ages 20-40 years); whereas, men have higher rates of PE after age 60 years. Women are tested for PE at far higher rates than men, yet women who undergo computed tomography pulmonary angiography are ultimately diagnosed with PE 35%-55% less often than men. Among those diagnosed with PE, women are more likely to have severe clinical features, such as hypotension and signs of right ventricular dysfunction. When controlled for PE severity, women are less likely to receive reperfusion therapies, such as thrombolysis. Finally, women have more bleeding complications for all types of anticoagulation. Further investigation of possible sex-specific diagnostic and treatment algorithms is necessary in order to more accurately detect and treat acute PE in non-pregnant adults.

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Influence of vascular enhancement, age and gender on pulmonary perfused blood volume quantified by dual-energy-CTPA

Cited by 21 publications

References 12 publications

Influence of age and sex on the longitudinal relaxation time, T1, of the lung in healthy never‐smokers

Influence of age and sex on the longitudinal relaxation time, T1, of the lung in healthy never‐smokers

Detection of pulmonary embolism with free-breathing dynamic contrast-enhanced MRI

Crucial considerations: Sex differences in the epidemiology, diagnosis, treatment, and outcomes of acute pulmonary embolism in non‐pregnant adult patients

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