Influence of Varying Proportions in Combinations of Estrone, Estradiol and Estriol on Biological Response

Grauer, Robert C.; Saier, Eleanor L.; Strickler, Herbert S.; Cutuly, Eugene

doi:10.3181/00379727-98-24027

Cited by 4 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Villee & Hagerman [1957] showed that oestriol would decrease oestradiol-17/3-induced activation of placental isocitricdehydrogenase in an in vitro system. Although mentioned by earlier workers [Huggins & Jensen, 1955 ;Velardo & Sturgis, 1955], the interactions of these substances on the rat vagina were not discussed specifically until we showed that at^E D 50 levels the responses to mixtures of oestrone and oestriol or oestradiol-ß and oestriol were simply additive [Edgren & Calhoun, 1957a], Grauer, Saier, Strickler & Cutuly [1958] reported 2i Endoc. 20,4 synergistic relationships of oestrone with oestradiol-ß, oestrone with oestriol and oestradiol-ß with oestriol; they did not find any inhibition of oestrone-induced rat uterine growth by oestriol.…”

mentioning

confidence: 88%

Oestrogen Antagonisms: The Effects of Oestriol and 16-Epioestriol on Oestrone-Induced Uterine Growth in Spayed Rats

Edgren¹,

Calhoun²

1960

Journal of Endocrinology

View full text Add to dashboard Cite

Studies on spayed rats treated simultaneously with mixtures of oestrone and oestriol showed that at low dose levels of oestrone the minor uterine growth response produced is augmented by oestriol; at intermediate doses of oestrone the response is inhibited by oestriol. Large doses of oestrone appear to be unaffected. 16-Epioestriol would appear to show a somewhat similar pattern of activities. We believe that these data suggest that oestriol, and perhaps 16-epioestriol, may act as a sort of biological buffer for the stronger oestrogens, maintaining the uterus when titres of the stronger oestrogens are low, restricting their actions when they are relatively high.

show abstract

mentioning

confidence: 88%

Oestrogen Antagonisms: The Effects of Oestriol and 16-Epioestriol on Oestrone-Induced Uterine Growth in Spayed Rats

Edgren¹,

Calhoun²

1960

Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…Delayed implantation can be maintained for many days by daily injection of P4, but the delayed state can be terminated by single E2 injection, and embryo implantation is initiated [14]. Delayed implantation can also be obtained by hypophysectomy in rat until the time estrogen plus progesterone or prolactin injected，or by autografts of the hypophysis [15,16]. Non-surgical methods that block estrogen's action or synthesis are also used to induce delayed implantation.…”

Section: Introductionmentioning

confidence: 99%

Delayed Implantation Induced by Letrozole in Mice

Wang

Meng

et al. 2022

Reprod. Sci.

View full text Add to dashboard Cite

Implantation timing is key for a successful pregnancy. Short delay in embryo implantation caused by targeted gene ablation produced a cascading problem in the later stages of the pregnancy. Although several delayed implantation models have been established in wild mice, almost none of them is suitable for investigating the delay on the late events of pregnancy. Here, we report a new delayed implantation model established by the intraperitoneally administration of letrozole at 5 mg/kg body weight on the day 3 of pregnancy. In these mice, initiation of implantation was induced at will by the injection of estradiol (E2). When the estradiol (3 ng) was injected on day 4 of pregnancy (i.e., without delay), the embryo implantation restarted, and the pregnancy continued normally.However, high dose of estrogen (25 ng) caused compromised implantation. We also found that only 67% of the female mice could be pregnant normally and finally gave birth when the injection of estradiol (3 ng) was on day 5 of pregnancy (i.e., one day delay). Most of the failed pregnancies had impaired decidualization, decreased plasma progesterone levels and compromised angiogenesis. Progesterone supplementation could rescue decidualization failure in the mice. Collectively, we established a new model of delayed implantation by letrozole, which can be easily used to study the effect and mechanisms of delay of embryo implantation on the progression of late pregnancy events.

show abstract

Delayed implantation induced by letrozole in mice

Wang

Meng

et al. 2021

Preprint

View full text Add to dashboard Cite

Implantation timing is key for a successful pregnancy. Short delay in embryo implantation caused by targeted gene ablation produced a cascading problem in the later stages of the pregnancy. Although several delayed implantation models have been established in wild mice, almost none of them is suitable for investigating the delay on the late events of pregnancy. Here, we report a new delayed implantation model established by the intraperitoneally administration of letrozole at 5 mg/kg body weight on the day 3 of pregnancy. In these mice, initiation of implantation was induced at will by the injection of estradiol (E2). When the estradiol (3 ng) was injected on day 4 of pregnancy (i.e., without delay), the embryo implantation restarted, and the pregnancy continued normally. However, high dose of estrogen (25 ng) caused compromised implantation. We also found that only 67% of the female mice could be pregnant normally and finally gave birth when the injection of estradiol (3 ng) was on day 5 of pregnancy (i.e., one day delay). Most of the failed pregnancies had impaired decidualization, decreased plasma progesterone levels and compromised angiogenesis. Progesterone supplementation could rescue decidualization failure in the mice. Collectively, we established a new model of delayed implantation by letrozole, which can be easily used to study the effect and mechanisms of delay of embryo implantation on the progression of late pregnancy events.

show abstract

Influence of Varying Proportions in Combinations of Estrone, Estradiol and Estriol on Biological Response

Cited by 4 publications

References 0 publications

Oestrogen Antagonisms: The Effects of Oestriol and 16-Epioestriol on Oestrone-Induced Uterine Growth in Spayed Rats

Oestrogen Antagonisms: The Effects of Oestriol and 16-Epioestriol on Oestrone-Induced Uterine Growth in Spayed Rats

Delayed Implantation Induced by Letrozole in Mice

Delayed implantation induced by letrozole in mice

Contact Info

Product

Resources

About