Influence of various light regimes on some circadian rhythms of transplantable melanoma B16
David A. Areshidze,
Maria A. Kozlova,
Denis V. Mishchenko
et al.
Abstract:BACKGROUND: Today it is known that disturbance of the lighting regime, expressed both by lengthening of the light period and its reduction, can not only affect the regulation of circadian rhythms of the organism, but also contributes to the initiation of neoplasm growth.
AIM: The aim of the study was to investigate circadian rhythmicity of melatonin level, some micromorphometric indices of tumor cells and expression of genes Bmal1, Clock and Per2 in them in mice with transplanted melanoma B16.
MATERIALS AND … Show more
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