Influence of various confounding variables and storage conditions on metanephrine and normetanephrine levels in plasma

Deutschbein, Timo; Unger, Nicole; Jaeger, Andrea; Broecker-Preuß, Martina; Mann, Klaus; Petersenn, Stephan

doi:10.1111/j.1365-2265.2009.03761.x

Cited by 45 publications

(36 citation statements)

References 34 publications

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“…Deutschbein et al found that MN levels were significantly influenced by sex and age. Our data are therefore in correspondence with the data of Deutschbein et al (20). They also found a relationship between plasma NMN levels and BMI and sex.…”

Section: Discussionsupporting

confidence: 81%

Plasma levels of free metanephrines and 3-methoxytyramine indicate a higher number of biochemically active HNPGL than 24-h urinary excretion rates of catecholamines and metabolites

Duinen

Corssmit

Jong

et al. 2013

European Journal of Endocrinology

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Context: A substantial number of patients with head and neck paragangliomas (HNPGLs) have biochemically active tumors, evidenced by increased urinary excretion of catecholamines and metabolites, including 3-methoxytyramine (3MT). It is unclear whether plasma levels of these parameters are more sensitive to detect biochemical activity in HNPGL patients than urinary excretion rates. Objective: To compare plasma free levels vs urinary excretion rates of deconjugated 3MT and combined metanephrines (MNs) in patients with HNPGL. Patients and methods: We included 124 consecutive patients with HNPGL for screening of catecholamine excess by measurement of 24-h urinary excretion rates of deconjugated (nor)metanephrine, (nor)epinephrine, dopamine, vanillylmandelic acid, 3MT, and plasma free levels of (nor)metanephrine and 3MT. Results: Plasma free 3MT levels were increased in 35 of the 124 patients (28%), whereas 24-h urinary excretion of deconjugated 3MT was increased in 30 patients (24%) (PZ0.13). Plasma free MN levels were increased in seven patients (6%) and urinary deconjugated MN levels in six patients (5%) (PZ1.00). Plasma free normetanephrine (NMN) levels were increased in seven patients (6%), and five patients had increased urinary excretion of deconjugated NMN (4%) (PZ0.69). Plasma free combined MN levels (NMN, MN, and 3MT) were increased in 41 patients (33%), whereas 24-h urinary excretion rates of deconjugated combined MNs were increased in 33 patients (27%, P!0.05). Conclusions: The combined levels of free MNs and free 3MT in plasma indicate a higher number of biochemically active HNPGLs than the 24-h urinary excretion rates of these markers.

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Section: Discussionsupporting

confidence: 81%

Plasma levels of free metanephrines and 3-methoxytyramine indicate a higher number of biochemically active HNPGL than 24-h urinary excretion rates of catecholamines and metabolites

Duinen

Corssmit

Jong

et al. 2013

European Journal of Endocrinology

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“…cessing and storage conditions [28]. In clinical practice, more robust clinical parameters such as the baroreflex sensitivity might be preferable to assess the autonomic shift in acute stroke patients [5].…”

Section: Discussionmentioning

confidence: 99%

Insular stroke is associated with acute sympathetic hyperactivation and immunodepression

Walter

Kolbaske

Patejdl

et al. 2012

Euro J of Neurology

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“…suggested that high local concentrations of cortisol in the adrenal gland are necessary to produce sufficient catecholamines . It has been described that during physical activity, the plasma catecholamines are elevated and play an important role during exercise . Patients with AD may be unable to generate these high local catecholamine levels in the adrenal gland.…”

Section: Discussionmentioning

confidence: 99%

Decreased physical activity, reduced QoL and presence of debilitating fatigue in patients with Addison's disease

Valk

Smans

Hofstetter³

et al. 2016

Clinical Endocrinology

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Influence of various confounding variables and storage conditions on metanephrine and normetanephrine levels in plasma

Cited by 45 publications

References 34 publications

Plasma levels of free metanephrines and 3-methoxytyramine indicate a higher number of biochemically active HNPGL than 24-h urinary excretion rates of catecholamines and metabolites

Plasma levels of free metanephrines and 3-methoxytyramine indicate a higher number of biochemically active HNPGL than 24-h urinary excretion rates of catecholamines and metabolites

Insular stroke is associated with acute sympathetic hyperactivation and immunodepression

Decreased physical activity, reduced QoL and presence of debilitating fatigue in patients with Addison's disease

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