Influence of Vagus Nerve on Catecholamine Production of Dog Lungs

Heitz, Molly; Brandt, H. D.; Kock, Martin; Gomes, Érica Alves

doi:10.1159/000194510

Cited by 1 publication

(1 citation statement)

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“…They were anaesthetized with pentobarbital sodium (20 mg/kg i.v. ), and maintained under anaesthesia using a constant intravenous pump delivering 4.4 mg of pentobarbital sodium/kg/h [4], the dogs were then paralyzed with succinylcholine (5 mg/kg). A trache ostomy was performed at the level of the second tra cheal cartilage, and a Portex tracheostomy tube No.…”

Section: Methodsmentioning

confidence: 99%

Interaction of Verapamil Hydrochloride and Atropine Sulphate on Histamine-Induced Bronchoconstriction

Krivoy¹,

Brandt²,

Bunn³

1985

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Submaximal histamine dose-response curves were obtained on 34 dogs divided into six groups. These groups were: A (n=6) untreated; B (n=6) after atropine (1 mg/kg); C (n=5) after verapamil inhalation (10 mg total dose); D (n=5) after verapamil inhalation (100 mg total dose); E and F (n=6) as for C and D but pre-treated with atropine (1 mg/kg). Total lung resistance (Rl) was measured in each case at increasing delivered concentrations of inhaled histamine and expressed as a ratio of baseline valve. For each group a composite mean curve was obtained and the maximal recorded responses (mean maximal resistance ratios) for the various groups were compared. It appears that the combination of verapamil inhalation (low dose) and atropine reduced the anticholinergic effect of atropine causing marked bronchoconstriction. This unexpected result depends on the verapamil dose since it was not present at the higher dose (group F).

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Section: Methodsmentioning

confidence: 99%