Abstract:Binding of the nonsteroidal anti-inflammatory drug, tolmetin, to plasma from uremic patients before hemodialysis and from healthy subjects was compared using micro-equilibrium dialysis techniques. The percent age of free tolmetin was 2–15 times greater in plasma from uremic patients (1.33–3.08%) than in plasma from healthy volunteers (0.37–0.63%) at all three concentrations of the drug studied (0.5, 5 and 50μg/ml). The reduced plasma binding of tolmetin in plasma from uremic patients was associated with signif… Show more
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