Influence of type of granulators on formation of seeded granules

Kitching, Victoria R.; Rahmanian, Nejat; Jamaluddin, Nurul Hanis; Kelly, Adrian L.

doi:10.1016/j.cherd.2020.05.017

Cited by 3 publications

(1 citation statement)

References 18 publications

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“…However, a small pitch element would be more desirable when the traversing material must be pressurised [38] Materials are affected by the conveying element in the three following key areas: con veying materials in the barrels, compaction axial generation, and the breaking of large lumps [37]. Kitching et al (2020) [39] suggest that the large granules that form along the conveying elements would have weak strength. This also highlights the fact that the con veying elements allow for the development of the seeding process with some level of low shear.…”

Section: Conveying Elementsmentioning

confidence: 99%

Process Simulation of Twin-Screw Granulation: A Review

Arthur,

Rahmanian

2024

Pharmaceutics

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Twin-screw granulation has emerged as a key process in powder processing industries and in the pharmaceutical sector to produce granules with controlled properties. This comprehensive review provides an overview of the simulation techniques and approaches that have been employed in the study of twin-screw granulation processes. This review discusses the major aspects of the twin-screw granulation process which include the fundamental principles of twin-screw granulation, equipment design, process parameters, and simulation methodologies. It highlights the importance of operating conditions and formulation designs in powder flow dynamics, mixing behaviour, and particle interactions within the twin-screw granulator for enhancing product quality and process efficiency. Simulation techniques such as the population balance model (PBM), computational fluid dynamics (CFD), the discrete element method (DEM), process modelling software (PMS), and other coupled techniques are critically discussed with a focus on simulating twin-screw granulation processes. This paper examines the challenges and limitations associated with each simulation approach and provides insights into future research directions. Overall, this article serves as a valuable resource for researchers who intend to develop their understanding of twin-screw granulation and provides insights into the various techniques and approaches available for simulating the twin-screw granulation process.

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Section: Conveying Elementsmentioning

confidence: 99%