Influence of type II 5′ deiodinase on TSH content in diabetic rats

Aláez, C; Calvo, Rosa; Obregón, Marı́a Jesús; Álvarez, Carmen; Goya, Luis; Escrivá, Fernando; Pascual-Leone, A. M.

doi:10.1007/bf03179815

Cited by 5 publications

(2 citation statements)

References 38 publications

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“…The TSH decrease can be ascribed to abnormalities in TRH-secreting hypothalamic neurons, lowering of sensitivity of the thyrotrophs to TRH, alterations in activity of the type 2 5′-deiodinase in the pituitary and the hypothalamus, reduced expression of TSH gene, and other causes [12,13,[29][30][31]. In Sprague-Dawley rats, 3 days after the DM1 induction, and in Wistar rats, 2 weeks after the STZ treatment, TSH level was significantly reduced [11,13].…”

Section: Endocrine Researchmentioning

confidence: 99%

The Influence of Intranasal Insulin on Hypothalamic-Pituitary-Thyroid Axis in Normal and Diabetic Rats

et al. 2015

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The functions of hypothalamic-pituitary-thyroid axis are attenuated in type 1 diabetes mellitus due to insulin deficiency. The use of intranasally administered insulin is of considerable interest for treatment of diabetes and cognitive disorders, but its effect on the thyroid system has not been investigated yet. We studied the influence of long-term treatment with intranasal insulin on the hypothalamic-pituitary-thyroid axis of nondiabetic rats and diabetic animals with streptozotocin models of acute and mild type 1 diabetes mellitus. This treatment was carried out for 28 days in acute (daily does of 0.3, 0.6, and 1.5?IU of insulin per rat) and for 135 days in mild diabetes (daily dose of 0.45?IU/rat). Nondiabetic rats were treated in a similar manner. Intranasal insulin in both models of diabetes resulted in the improvement of thyroid status; manifested as increase of thyroid hormones levels and restoration of response to thyroliberin. In acute diabetes, a daily dose of 0.6?IU/rat was the most effective. Twenty eight days treatment of nondiabetic rats with intranasal insulin at a dose of 0.3?IU/rat resulted in a significant increase of free and total thyroxine levels. Longer treatment of rats with mild diabetes and nondiabetic animals significantly increased thyrotropin level. Thus, long-term intranasal insulin treatment restored the hypothalamic-pituitary-thyroid axis function in type 1 diabetes, but led to a significant increase in the thyrotropin level, which must be considered when designing a strategy for the use of intranasal insulin in clinical applications.

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Section: Endocrine Researchmentioning

confidence: 99%

The Influence of Intranasal Insulin on Hypothalamic-Pituitary-Thyroid Axis in Normal and Diabetic Rats

et al. 2015

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“…In experimentally induced diabetes, thyroid-stimulating hormone (TSH) release is reduced along with a decrease in peripheral deiodinase activity, and as such a defect in the conversion of thyroxin to triiodothyronine (T4 to T3) has been reported. 27 Patients with poorly controlled diabetes may have an impaired TSH response to thyrotropin-releasing hormone stimulation with decreased T4-to-T3 conversion. A significant improvement in the above changes by optimizing glycemic control has also been reported.…”

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confidence: 99%