Influence of Turkish origin on hematology reference intervals in the German population

Mayr, Franz X; Bertram, Alexander; Cario, Holger; Frühwald, Michael C.; Groß, Hans‐Jürgen; Groening, Arndt; Grützner, Stefanie; Gscheidmeier, Thomas; Hoffmann, Reinhard; Krebs, Alexander; Ruf, Hans-Georg; Torge, Antje; Woelfle, Joachim; Razum, Oliver; Rauh, Manfred; Metzler, Markus; Zierk, Jakob

doi:10.1038/s41598-021-00566-2

Cited by 4 publications

(1 citation statement)

References 33 publications

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“…Biological reference intervals (RIs) are an important basis for clinicians to interpret patients’ test results. The direct method for establishing RIs has been recommended as the gold standard in recent years ( 1 ). However, a new indirect method based on data mining techniques is gaining attention because it saves time and money and guarantees a sample size for each interval when stratifying ( 2 , 3 ).…”

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confidence: 99%

Establishment of gender- and age-specific reference intervals for serum liver function tests among the elderly population in northeast China

Sun

Chai

Zhou

et al. 2022

Biochem. med. (Online)

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Reference intervals (RIs) for younger population may not apply to the elderly population. The aim of this study was to establish gender- and age-specific RIs for serum liver function tests among the elderly population and to compare with younger population RIs currently used in China and other countries. This was a retrospective study, and subjects (≥ 18 year-old) were recruited from the laboratory information system (LIS) at the First Hospital of Jilin University between April 2020 and April 2021. The following parameters were collected: aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyltransferase (GGT), alkaline phosphatase (ALP), total protein (TP), albumin (ALB), total bilirubin (TBIL), and direct bilirubin (DBIL). The Tukey method was used to eliminate outliers. Reference intervals were established by the nonparametric method. A total of 23,597 healthy individuals were enrolled in the study. From all parameters AST, ALT, TP and ALB required no gender partition, while ALT, GGT, TP, ALB and DBIL required different partitions for age. Activities and concentrations of ALT, ALB, and TP showed a downward trend in the elderly aged 60-89. In contrast, DBIL showed a gradual upward trend. The RIs for liver function tests among healthy elderly population were different from those among young population in China. There were apparent gender and age differences in the RIs of liver function for elderly and significant differences compared with national standards and RIs in other countries. Therefore, it is necessary to establish gender- and age-specific RIs for serum liver function tests among the elderly population.

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Section: Introductionmentioning

confidence: 99%

Establishment of gender- and age-specific reference intervals for serum liver function tests among the elderly population in northeast China

Sun

Chai

Zhou

et al. 2022

Biochem. med. (Online)

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Unsupervised machine learning method for indirect estimation of reference intervals for chronic kidney disease in the Puerto Rican population

Velev,

LeBien,

Roche-Lima

2023

Sci Rep

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Reference intervals (RIs) for clinical laboratory values are extremely important for diagnostics and treatment of patients. However, the determination of these ranges is costly and time-consuming. As a result, often different unverified RIs are used in practice for the same analyte and the same range is used for all patients despite evidence that the values are gender, age, and ethnicity dependent. Moreover, the abnormal flags are rudimentary, merely indicating if a value is within the RI. At the same time, clinical lab data generated in the everyday medical practice contains a wealth of information, that given the correct methodology, can help determine the RIs for each specific segment of the population, including populations that suffer from health disparities. In this work, we develop unsupervised machine learning methods, based on Gaussian mixtures, to determine RIs of analytes related to chronic kidney disease, using millions of routine lab results for the Puerto Rican population. We show that the measures are both gender and age dependent and we find evidence for normal age-related organ function deterioration and failure. We also show that the joint distribution of measures improves the diagnostic value of the lab results.

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Current status and challenges in establishing reference intervals based on real-world data

Qin

et al. 2023

Critical Reviews in Clinical Laboratory Sciences

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Influence of Turkish origin on hematology reference intervals in the German population

Cited by 4 publications

References 33 publications

Establishment of gender- and age-specific reference intervals for serum liver function tests among the elderly population in northeast China

Establishment of gender- and age-specific reference intervals for serum liver function tests among the elderly population in northeast China

Unsupervised machine learning method for indirect estimation of reference intervals for chronic kidney disease in the Puerto Rican population

Current status and challenges in establishing reference intervals based on real-world data

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