Influence of Tumor Site and Histology on Long-Term Survival in 193 Children with Extracranial Germ Cell Tumors

Backer, Antoine De; Madern, Gerard C.; Pieters, Rob; Haentjens, Patrick; Hakvoort-Cammel, F. G. A. J.; Jw, Oosterhuis; Hazebroek, F. W. J.

doi:10.1055/s-2007-989399

Cited by 52 publications

(31 citation statements)

References 18 publications

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“…6 The primary origin of such tumors is the testis in the male and the ovary in the female. 7 There are some rare reports of an extragonadal occurrence of ESTs involving the omentum, 7 nasal cavity, 8 and head and neck region; 8 the sacrococcygeal, 9 retroperitoneum, 9 mediastinum, 9 and the paranasal sinuses; 10 the parotid gland; 11 the oral cavity; 12 the liver; the brain; and the vagina. 2 The pathology underlying EGCTs has been suggested to be an abnormal migration of primordial germ cells from the ectoderm of the yolk sac or misplaced totipotential cells of the blastula to the morula stage of embryogenesis.…”

Section: Discussionmentioning

confidence: 99%

Yolk-Sac Tumor of the Postauricular Region: Case Report and Review of the Literature

Rozbahany

Hasanzadazar

Latifi

et al. 2012

Journal of Oral and Maxillofacial Surgery

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Section: Discussionmentioning

confidence: 99%

Yolk-Sac Tumor of the Postauricular Region: Case Report and Review of the Literature

Rozbahany

Hasanzadazar

Latifi

et al. 2012

Journal of Oral and Maxillofacial Surgery

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“…However, the YST usually occurs in younger patients, and most of them occur in the ovaries and testis. About 20% arise in extraovarian sites, including the mediastinum, sacrococcygeal region, cervix, vulva, pelvis, and retroperitoneum [19-24]. We do not believe primary H-YST of the seminal vesicle has been reported in the literature.…”

Section: Discussionmentioning

confidence: 99%

Seminal vesicle metastasis after partial hepatectomy for hepatocellular carcinoma

Gong

Zheng

et al. 2011

BMC Cancer

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BackgroundMetastasis to the seminal vesicle is extremely rare for hepatocellular carcinoma (HCC). To our knowledge, it has been not reported in literature. The purpose of the present paper was to report a case of metastasis to the seminal vesicle after HCC resection, along with its histological features and immunohistochemical characteristics.Case PresentationA 46-year-old Chinese man was admitted to our hospital due to abdominal distension. He had a history of HCC related to hepatitis B virus infection. Moreover, left partial hepatectomy was performed in another hospital 28 months ago, and right partial hepatectomy for HCC recurrence in our hospital 4 months ago. After resection, radiofrequency ablation therapy had been performed. About 27 months after the initial operation, contrast-enhanced computed tomography (CT) of the pelvic cavity revealed a mass with homogeneous enhancement in the seminal vesicle. Transrectal needle biopsy revealed a poorly differentiated adenocarcinoma. Therefore, seminal vesiculectomy was resected. The histological diagnosis of the removed tumor was compatible with the original HCC. Immunohistochemical examination demonstrated that the tumor cells were positive for glypican-3 (GPC3), alpha-fetoprotein (AFP), hepatocyte paraffin-1 (Hep Par 1), cytokeratin 18 (CK 18), and hepatocyte antigen, which confirmed that the seminal vesicle tumor was a metastatic tumor of HCC. However, CT subsequently revealed multiple metastatic foci in the abdominal and pelvic cavities in May 2009 and August 2009, respectively.ConclusionThe seminal vesicle is an extremely rare metastatic site for HCC, and the prognosis is very poor. A combination of clinical and pathological features is necessary for a correct diagnosis, and primary tumor should be excluded before diagnosing metastatic foci.

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“…The clinical characteristics and initial symptoms differ depending on the tumor site and histology [27,28]. A study of a german cohort of 1442 children shows, that most GCT arise in the ovary (29,3%), followed by the CNS (20,9%), the sacrococcygeal region (19,3%), the testis (17,3%), the mediastinum (4,3%), the retroperitoneum (3,5%) and other extragonadal sites such as head and neck-region and the vagina (5,4%) [27].…”

Section: Typical Features Of Specific Malignanciesmentioning

confidence: 99%

Timely identification of children with cancer

et al. 2013

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AbstractBackground. Cancer in childhood is rare, but nevertheless one of the most frequent causes of disease related death. Initial symptoms are often unspecific, frequently leading to a delay of cancer diagnosis. As a timely diagnosis can be crucial for the clinical outcome, our aim is to point out when unspecific symptoms should be considered suspect of being associated with specific cancer entities. Data sources. A systematic literature research in PubMed and current biliographies, as well as an evaluation of published epidemiologic data was performed. Results. This article reviews the typical presenting features and epidemiologic characteristics of the more common childhood malignancies, elucidates when specific and virtually unspecific symptoms require further evaluation, and gives advice how to start a rational diagnostic workup. Furthermore, genetic syndromes requiring increased watchfulness for cancer in childhood are demonstrated. Conclusion. Patients showing suspect symptoms should early be referred to specialized centres to assure optimal diagnostic and therapeutic capabilities.

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Influence of Tumor Site and Histology on Long-Term Survival in 193 Children with Extracranial Germ Cell Tumors

Abstract: Mortality in children with extracranial germ cell tumors is not only dictated by malignant histology, but also, as in the case of mature teratomas, by occurrence at certain sites.

Cited by 52 publications

References 18 publications

Yolk-Sac Tumor of the Postauricular Region: Case Report and Review of the Literature

Yolk-Sac Tumor of the Postauricular Region: Case Report and Review of the Literature

Seminal vesicle metastasis after partial hepatectomy for hepatocellular carcinoma

Timely identification of children with cancer

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