Influence of Tumor Location on Lymph Node Metastasis and Survival for Early Gastric Cancer: a Population-Based Study

Yang, Zelong; Chang, Zhenyu; Long, Jianhai; Zhu, Min; Zhang, Kecheng; Chun-xi, Wang

doi:10.1007/s11605-019-04367-x

Cited by 11 publications

(12 citation statements)

References 25 publications

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“…For metastatic patients, our survival analysis found that diffuse‐ and intestinal‐type patients also had a comparable prognosis. Regarding the primary site, a previous study reported that the tumor location was not an LNM predictor for patients with SGC 28 . In our study, the primary site was found to be a strong predictor of DM in patients with SGC‐NLNM.…”

Section: Discussionsupporting

confidence: 48%

“…Regarding the primary site, a previous study reported that the tumor location was not an LNM predictor for patients with SGC. 28 In our study, the primary site was found to be a strong predictor of DM in patients with SGC-NLNM. The primary sites of the cardia, gastric body, fundus, greater curve, and overlapping/NOS were associated with a higher risk of DM than the antrum/pylorus.…”

Section: Discussionsupporting

confidence: 47%

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A clinical model to predict distant metastasis in patients with superficial gastric cancer with negative lymph node metastasis and a survival analysis for patients with metastasis

Chen

Zhang

et al. 2020

Cancer Medicine

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Section: Discussionsupporting

confidence: 48%

Section: Discussionsupporting

confidence: 47%

A clinical model to predict distant metastasis in patients with superficial gastric cancer with negative lymph node metastasis and a survival analysis for patients with metastasis

Chen

Zhang

et al. 2020

Cancer Medicine

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“…Many scholars have tried to identify the risk factors of LNM in previous studies. It was reported that the rates of LNM in intramucosal or EGC varied greatly, ranging from 0.4% to 24% (2,3,6,7). According to histological manifestation, EGC is divided into differentiated and undifferentiated type, the former covers papillary adenocarcinoma, well and moderately-differentiated tumor and the latter includes poorly-differentiated tumor and signet ring cell carcinoma (SRCC) (8).…”

Section: Original Articlementioning

confidence: 99%

“…According to histological manifestation, EGC is divided into differentiated and undifferentiated type, the former covers papillary adenocarcinoma, well and moderately-differentiated tumor and the latter includes poorly-differentiated tumor and signet ring cell carcinoma (SRCC) (8). For total or differentiated EGC, various demographic and clinicopathological features were picked out as the risk factors of LNM from original research, meta-analysis or data of Surveillance, Epidemiology and End Results program (SEER), such as patients' gender (6), age (9), tumor location (3,6), gross pattern (10), tumor size (10), ulcerative lesion (UL) (2), depth of invasion (11), histological differentiation (10), and lymphovascular invasion (LVI) (11). For pure undifferentiated EGC, gender, age, tumor location, tumor size, gross pattern, LVI, and depth of invasion were also identified as the risk factors of LNM in previous studies (12)(13)(14).…”

Section: Original Articlementioning

confidence: 99%

“…Gastric cancer (GC) is the fifth most common cancer and the third leading cause of cancer death worldwide, responsible for over 1,000,000 new cases in 2018 and 1 in every 12 deaths globally (1). Although the high mortality GC causes, the early diagnosis and intervention improve the 5-year survival rate from 20-30% in patients at late stage (2) to 70-90% in early gastric cancer (EGC) (3,4).…”

Section: Introductionmentioning

confidence: 99%

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Risk factors of tumor invasion and node metastasis in early gastric cancer with undifferentiated component: a multicenter retrospective study on biopsy specimens and clinical data

Zou¹,

Wu²,

Yang³

et al. 2020

Ann Transl Med

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Background: Early gastric cancer (EGC) with undifferentiated component (UDC) is a more aggressive entity, where the significance of preoperative data to tumor invasion and lymph node metastasis (LNM) remains unclarified.Methods: A total of 5,020 GC patients undergoing radical gastrectomy in three centers were reviewed, of which, EGC with UDC in preoperative biopsy specimens were enrolled. The histology of biopsy and surgical specimens was graded according to the proportion of UDC and signet ring cells (SRCs). Risk factors of tumor invasion and LNM were evaluated with histological, clinical and demographic data.Results: Lower body mass index (BMI), melena and larger tumor size were the independent preoperative risk factors of both LNM and LVI, while ulcerative lesion (UL) and the lower third stomach were only correlated with LNM. No relevance was found between the histological features of biopsy specimens and LNM, but SRC or >50% UDC lowered the risk of lymphovascular invasion (LVI) and/or submucosal (SM) invasion. When surgical data (depth of invasion and LVI included) were added, lower BMI, melena and the lower third stomach were still the independent preoperative risk factors of LNM, and LVI, SRC and SM invasion also showed relevance to LNM. The performance of predictive models using pre-or postoperative histological data was comparable. Conclusions:The preoperative data were significantly relevant to tumor invasion and LNM, showing comparable risk strength with surgical specimens in histology.

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Risk of lymph node metastasis in early gastric cancer for a Western population

Watanabe

McKendry

Yip

et al. 2022

Journal of Surgical Oncology

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Introduction: Endoscopic resection (ER) of early gastric cancer (EGC) is increasingly used in Eastern countries due to their low rates of lymph node metastasis (LNM); however, there is a paucity of evidence in Western countries. We investigated LNM and its effect on overall survival (OS) in Western patients with EGC.Methods: Patients diagnosed with T1 gastric cancer between 2000 and 2017 were retrospectively evaluated. Univariate Kaplan-Meier, multivariate logistic and Coxregression models were used to assess the associations between clinical characteristics, LNM, and OS.Results: Among 86 patients, median age was 68 years and 72% were male. Node positivity was 30%. Two percent of patients met the classical guidelines for ER and all were node-negative, while 16% met expanded criteria of which 14% were nodepositive. T1b disease (odds ratio [OR] 41.2 [95% confidence interval [CI] 1.62-1048], p = 0.02) and lymphovascular/perineural invasion (OR 18.0 [95% CI 2.41 -134], p = 0.01) were predictive of node positivity. The 5-year OS for nodenegative and node-positive patients was 84% and 53% (p = 0.004), respectively. Conclusions:The risk of LNM in Western patients with EGC is higher; therefore, generalizability of the expanded criteria for ER should be interpreted with caution.

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Influence of Tumor Location on Lymph Node Metastasis and Survival for Early Gastric Cancer: a Population-Based Study

Cited by 11 publications

References 25 publications

A clinical model to predict distant metastasis in patients with superficial gastric cancer with negative lymph node metastasis and a survival analysis for patients with metastasis

A clinical model to predict distant metastasis in patients with superficial gastric cancer with negative lymph node metastasis and a survival analysis for patients with metastasis

Risk factors of tumor invasion and node metastasis in early gastric cancer with undifferentiated component: a multicenter retrospective study on biopsy specimens and clinical data

Risk of lymph node metastasis in early gastric cancer for a Western population

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