Influence of TT virus infection on the thrombocytopenia of patients with chronic liver disease

Tokita, Hajime; Murai, Seiyou; Kamitsukasa, Hiroshi; Yagura, Michiyasu; Harada, Hideharu; Takahashi, Masaharu; Okamoto, Hiroaki

doi:10.1016/s1386-6346(00)00146-7

Cited by 14 publications

(11 citation statements)

References 40 publications

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“…But Udomsakdi-Auewarakul et al [24] in Thailand found no supportive evidence that patients with newly diagnosed aplastic anaemia showed a higher TTV prevalence. According to Tokita et al [25], among patients with chronic hepatitis C or chronic hepatitis without serological markers of ongoing HBV or HCV virus infection (CH-NBNC), the platelet count was significantly lower in the genotype 1 TTV þ group than in the genotype 1-negative TTV À group.…”

Section: Haematologic Disordersmentioning

confidence: 99%

“…In the bone marrow, TTV may prefer the erythroid series, because the promoter activity of TTV was most significant in K562 cells of erythroid origin [49], and/or the megakaryocyte series, because thrombocytopaenia has been reported in TTV infected patients [25]. However, TTV replication in peripheral blood cells may not be so important because granulocytes with the highest TTV load among blood cells showed 0.3 copies/cell maximum [50].…”

Section: Target Cells Of Ttvmentioning

confidence: 99%

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Torque teno virus (TTV): current status

Hino

Miyata

2006

Reviews in Medical Virology

168

133

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Torque teno virus (TTV), currently classified into the family Circoviridae, genus Anellovirus, was first found in a patient with non-A-E hepatitis. TTV has a single stranded circular DNA of approximately 3.8 kb. TTVs are extraordinarily diverse, spanning five groups including SANBAN and SEN viruses. Torque teno mini virus (TTMV) with approximately 2.9 kb genome also has wide variants. Recently, two related 2.2- and 2.6-kb species joined this community. Recombinations between variants are frequent. This extensive TTV diversity remains unexplained; it is unclear how TTVs could be viable, and why they require such genetic variation. An unequivocal culture system is still not available. TTVs are ubiquitous in > 90% of adults worldwide but no human pathogenicity of TTV has been fully established. Epidemiological surveys need to specify the variants being studied and clinical targets, and must calibrate the sensitivity of the assay used. Potentially interesting observations include a higher viral load in patients with severe idiopathic inflammatory myopathies, cancer and lupus. Active replication was also found in infants with acute respiratory diseases. TTV/TTMV-related viruses were found in chimpanzees, apes, African monkeys and tupaias, and also in chickens, pigs, cows, sheep and dogs. Experimentally, rhesus monkeys were persistently infected by TTV, but only 1/53 chimpanzees. TTV transcribes three species of mRNAs, 3.0-, 1.2- and 1.0-kb in the ratio of 60:5:35. Recently, at least three mRNAs were shown in chicken anaemia virus. The genomic region -154/-76 contains a critical promoter. TTV seems to have at least three proteins; however, the definite functions of these proteins await further research work.

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Section: Haematologic Disordersmentioning

confidence: 99%

Section: Target Cells Of Ttvmentioning

confidence: 99%

Torque teno virus (TTV): current status

Hino

Miyata

2006

Reviews in Medical Virology

168

133

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“…Therefore, it is possible that TTV may have a similar adverse effect on bone marrow function, particularly in association with immune suppression. Indeed, some reports link TTV replication to thrombocytopenia and aplastic anaemia [29][30][31]. Of great potential interest is the possibility that many of the haematological complications of AIDS, such as neutropenia, thrombocytopenia and anaemia may be the direct result of increased TTV replication in the bone marrow.…”

Section: Disease Associations Of Ttvmentioning

confidence: 99%

TT virus infection: a novel virus-host relationship

Simmonds¹

2002

Journal of Medical Microbiology

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“…The replicative intermediate forms of TTV DNA are found in BM cells but not in PB MNCs [16]. The effect of TTV/1a on the growth of hematopoietic cells might be more critical than that of the other genotypes [25]. In BM cells, TTV may prefer the erythroid lineage cells because the promoter activity of TTV was highest in K562 cells (erythroid origin) than other cell lines including HepG2 and Huh7 cells [9].…”

Section: Discussionmentioning

confidence: 99%

Hepatitis-associated aplastic anemia during a primary infection of genotype 1a torque teno virus

et al. 2009

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A 12-year-old Japanese boy suffered from severe acute hepatitis and pancytopenia. The patient underwent successful bone marrow transplantation from an HLA-identical sister. Torque teno virus (TTV) DNA of genotype 1a and IgM-class antibody against the virus were detected in sera at the onset of hepatitis. TTV/1a DNA and anti-TTV/1a IgM antibody levels were undetectable on the 16th and 46th days after the onset of illness, respectively. Anti-TTV/1a IgG antibody was positive throughout the observation period. Sequential viral load and anti-TTV/1a IgM antibody suggested a primary infection of TTV/1a. Genomic sequence of the virus coincided with that of the original strain first isolated from human. TTV DNA was quantified at 130 copies in 10(5) bone marrow mononuclear cells, which suggested that infection of hematopoietic cells might be the cause of aplasia. This is the first report of TTV hepatitis-associated aplastic anemia assessed by the anti-TTV antibodies and viral load in peripheral blood and bone marrow.

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Influence of TT virus infection on the thrombocytopenia of patients with chronic liver disease

Cited by 14 publications

References 40 publications

Torque teno virus (TTV): current status

Torque teno virus (TTV): current status

TT virus infection: a novel virus-host relationship

Hepatitis-associated aplastic anemia during a primary infection of genotype 1a torque teno virus

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