Influence of Transversal Resolution on Reconstructing Atherosclerotic Plaque Components

Lisický, Ondřej; Malá, Aneta; Burša, Jiří

doi:10.1007/978-3-030-32040-9_51

Cited by 1 publication

(2 citation statements)

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“…We focused on segmentation of the FT and LC (including the regions of calcification). As biological structures are characterized by smooth surfaces [8], the geometry was smoothed [24] with the same parameters for all the models. Since the individual vessel wall layers cannot be distinguished in the in vivo MRI scans and the sample harvested at endarterectomy cannot include the media and adventitia layers of the wall, the outer surface of the obtained geometry was used to create the volume of the missing layers.…”

Section: D Ps Model Of Carotid Artery With Atheromamentioning

confidence: 99%

“…Study Lisický et al [24] investigated the ST impact on magnitudes of surfaces and volumes of the atherosclerotic plaque components and found only slight impact of the ST in the whole investigated range between 0.25 to1.5 mm, with a negligible impact between 0.5 and 1 mm. In this work, we found that ST was significant for sample 2 while insignificant for sample 1.…”

Section: Slice Thicknessmentioning

confidence: 99%

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Consideration of stiffness of wall layers is decisive for patient-specific analysis of carotid artery with atheroma

et al. 2020

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The paper deals with the impact of chosen geometric and material factors on maximal stresses in carotid atherosclerotic plaque calculated using patient-specific finite element models. These stresses are believed to be decisive for the plaque vulnerability but all applied models suffer from inaccuracy of input data, especially when obtained in vivo only. One hundred computational models based on ex vivo MRI are used to investigate the impact of wall thickness, MRI slice thickness, lipid core and fibrous tissue stiffness, and media anisotropy on the calculated peak plaque and peak cap stresses. The investigated factors are taken as continuous in the range based on published experimental results, only the impact of anisotropy is evaluated by comparison with a corresponding isotropic model. Design of Experiment concept is applied to assess the statistical significance of these investigated factors representing uncertainties in the input data of the model. The results show that consideration of realistic properties of arterial wall in the model is decisive for the stress evaluation; assignment of properties of fibrous tissue even to media and adventitia layers as done in some studies may induce up to eightfold overestimation of peak stress. The impact of MRI slice thickness may play a key role when local thin fibrous cap is present. Anisotropy of media layer is insignificant, and the stiffness of fibrous tissue and lipid core may become significant in some combinations.

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Section: D Ps Model Of Carotid Artery With Atheromamentioning

confidence: 99%

Section: Slice Thicknessmentioning

confidence: 99%