Influence of transforming growth factor-β1 and tumor necrosis factor-α genes polymorphisms on the development of cirrhosis and hepatocellular carcinoma in chronic hepatitis C patients

Radwan, Mohamed; Pasha, Heba F.; Mohamed, Rasha H.; Hussien, Hala I.M.; El-Khshab, Mohamed N.

doi:10.1016/j.cyto.2012.05.010

Cited by 59 publications

(43 citation statements)

References 40 publications

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“…In our study, subjects carrying the T allele at position -509 were associated with higher serum concentrations of TGF-β1 in the patient and control groups, suggesting that the T allele modulates serum concentrations of TGF-β1. These results agreed with those of Radwan et al (2012), who reported that the presence of the T allele at position -509 was associated with higher concentrations of TGF-β1. The opposite results were obtained in a study conducted by Qi et al (2009), which suggested that the presence of a C allele at position -509 of the TGF-β1 gene may lead to higher plasma TGF-β1 levels in HCC patients with chronic hepatitis B virus infection in a Chinese population.…”

Section: Discussionsupporting

confidence: 83%

TGF-β1 polymorphism 509 C>T is associated with an increased risk for hepatocellular carcinoma in HCV-infected patients

Ma¹,

Liu²,

Fang³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Transforming growth factor-beta 1 (TGF-β1), a member of the transforming growth factor beta family, functions as a multi-functional cytokine and plays a key role in cellular growth, proliferation, and differentiation. The 509 C/T polymorphism in the TGF-β1 gene has been implicated in the outcome of hepatitis C virus (HCV) infection; however, little is known regarding the relationship between TGF-β1 gene mutations and the development of hepatocellular carcinoma (HCC) in HCV-infected patients. The aim of the study was to evaluate the effect of the TGF-β1 polymorphisms 509 C>T on the occurrence of HCC in patients chronically infected with HCV in a Chinese Han population. The results showed that HCC patients had a higher frequency of the TGF-β1 -509 TT genotype distribution of the TGF-β1 -509 polymorphism and a lower frequency of the CC genotype. Serum TGF-β1 levels were significantly higher in patients with the TT genotype than in those with the CC genotype. In this study, we confirmed that the TGF-β1 polymorphism 509 C>T is associated with the risk of HCC in HCV-infected patients.

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Section: Discussionsupporting

confidence: 83%

TGF-β1 polymorphism 509 C>T is associated with an increased risk for hepatocellular carcinoma in HCV-infected patients

Ma¹,

Liu²,

Fang³

et al. 2015

Genet. Mol. Res.

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“…Fourteen association studies relating to the TGF-b1 polymorphisms with susceptibility to HCC met the inclusion requirements for the meta-analysis (Ben-Ari et al, 2003;Kwon et al, 2003;Migita et al, 2005;Falleti et al, 2008;Zhang, 2008;Qin, 2009Qin, , 2012Okamoto et al, 2010;Miki et al, 2011;Yang, 2011;Radwan et al, 2012;Shi et al, 2012;Xin et al, 2012;Wei et al, 2012). There were six studies on + 869C/T polymorphism, nine studies on -509C/T polymorphism, and three studies on + 915C/G polymorphism.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Five polymorphisms have been identified: two in the promoter region at positions -800 and -509, one at position + 72 in a nontranslated region, and two in the signal sequence at positions + 869 and + 915. Some studies have investigated the associations between the TGF-b1 polymorphisms and susceptibility of HCC (Ben-Ari et al, 2003;Kwon et al, 2003;Migita et al, 2005;Falleti et al, 2008;Zhang, 2008;Qin, 2009Qin, , 2012Okamoto et al, 2010;Miki et al, 2011;Yang, 2011;Radwan et al, 2012;Shi et al, 2012;Xin et al, 2012;Wei et al, 2012). Most of the studies focused on two polymorphisms: + 869C/T (rs1800470) and -509C/T (rs1800469).…”

Section: Introductionmentioning

confidence: 99%

Association Between TGF-β1 Polymorphisms and Hepatocellular Carcinoma Risk: A Meta-Analysis

Guo

Zang²,

Li³

et al. 2013

Genetic Testing and Molecular Biomarkers

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Background: Associations between transforming growth factor (TGF)-b1 polymorphisms and hepatocellular carcinoma (HCC) risk remained controversial. Therefore, we performed this meta-analysis to investigate these associations. Methods: We searched Pubmed, EMBASE, Chinese National Knowledge Infrastructure (CNKI), and Wanfang databases for studies before March 2013. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strength of association. Results: A total of 14 studies were included in this meta-analysis. TGF-b1 + 869C/T polymorphism was significantly associated with HCC risk (OR = 1.74, 95% CI: 1.22-2.47, p = 0.002). In addition, a significant association between -509C/T polymorphism and HCC risk was observed (OR = 1.40, 95% CI: 1.15-1.70, p = 0.0007). Furthermore, significant associations between these polymorphisms and HCC risk were found in Asians and population-based studies. Conclusions: Our meta-analysis suggested that the TGF-b1 + 869C/T and -509C/T polymorphisms may be risk factors for developing HCC.

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“…After TNF-α activation, Kupffer cells secrete TGF-beta1, an important fibrogenic molecule. The relationship between cirrhosis development and TNF promoter has been investigated extensively (34,35,36,37). Although Romero-Gómez et al (38) found no association between polymorphism in -308 and the severity of fibrosis in HCV and Abdel-Latif found (11) in both fibrotic and cirrhotic cases, no significant correlation was observed in levels of matrix metalloproteinases (MMP)-2, MMP-9, and TNF-α between fibrotic and cirrhotic cases (39).…”

Section: Discussionmentioning

confidence: 99%

TNF-alpha 308 SNP Rs3091256 GG Genotype is Strongly Associated with Fibrosis in Patients with Chronic Hepatitis C

Günal¹,

Yalçin²,

Çelik³

et al. 2017

vhd

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ÖZObjective: We aimed to review the influence of host genetic factors on the clinical course, treatment response as well as fibrosis progression in patients with viral hepatitis C genotype 1. Materials and Methods: Ninety-five patients with chronic hepatitis C virus (HCV) infection and 97 controls were enrolled. The patients received pegylated interferon (Peg-IFN)+ribavirin therapy for 48 weeks and were followed up for the next 48 weeks. Aspartat aminotransferase/platelet ratio (APRI) was used to detect liver fibrosis DNA specimens were extracted from the peripheral blood mononuclear cells and the tumor necrosis factor-alpha (TNF-α) 308 rs3091256 was genotyped by the polymerase chain reactionrestriction fragment length polymorphism method. Results: All patients included in the study were infected with HCV genotype 1. of the 95 HCV-positive patients, spontaneous viral clearence was observed in 25.5%, rapid viral response in 44.2%, early viral response in 91.8%, and sustained viral response was found in 73.3% of patients. The allele and genotype were not significant between patients and controls. There was no significant difference in virologic response as well. However, TNF-α-308 single nucleotide polymorphisms (SNP) rs3091256 GG genotype was strongly associated with fibrosis and alanine aminotransferase (ALT) levels (p=0.006 and p=0.017, respectively). Conclusion: TNF-α-308 polymorphisms may reveal different results among countries. Patients having SNP rs3091256 GG are prone to have higher ALT levels and fibrosis score but have better treatment outcome.

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Influence of transforming growth factor-β1 and tumor necrosis factor-α genes polymorphisms on the development of cirrhosis and hepatocellular carcinoma in chronic hepatitis C patients

Cited by 59 publications

References 40 publications

TGF-β1 polymorphism 509 C>T is associated with an increased risk for hepatocellular carcinoma in HCV-infected patients

TGF-β1 polymorphism 509 C>T is associated with an increased risk for hepatocellular carcinoma in HCV-infected patients

Association Between TGF-β1 Polymorphisms and Hepatocellular Carcinoma Risk: A Meta-Analysis

TNF-alpha 308 SNP Rs3091256 GG Genotype is Strongly Associated with Fibrosis in Patients with Chronic Hepatitis C

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