Influence of total colectomy on serum antineutrophil cytoplasmic antibodies in inflammatory bowel disease

Patel, R. T.; Stokes, R. P.; Birch, D. W.; Ibbotson, J. P.; Keighley, M. R. B.

doi:10.1002/bjs.1800810535

Cited by 49 publications

(18 citation statements)

References 19 publications

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“…Initial studies in the 1990s examining the correlation between pANCA and pouchitis produced conflicting results. Some studies have shown a correlation between pANCA presence and the development of pouchitis,124–128 while others have not 88, 198–202. However, these early studies were retrospective in design and included relatively small sample sizes.…”

Section: Disease Stratification and Prediction In Ucmentioning

confidence: 99%

Serological Antibodies in Inflammatory Bowel Disease: A Systematic Review

Prideaux

Cruz

et al. 2012

Inflammatory Bowel Diseases

174

148

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The diagnosis of inflammatory bowel disease (IBD) is traditionally based on a combination of clinical, endoscopic, histological, and radiological criteria. However, further testing is needed in cases of diagnostic uncertainty and in predicting disease course. This systematic review focuses on the potential for 10 serological antibodies to fill these roles: pANCA, ASCA, anti-OmpC, anti-CBir1, anti-I2, ALCA, ACCA, AMCA, anti-L, and anti-C. We discuss their prevalence in IBD and health; their role in disease diagnosis and risk stratification; their stability over time; their presence in unaffected relatives; their association with genetic variants; and differences across ethnic groups. Serological antibodies have some role in primary diagnosis and in differentiating between Crohn's disease and ulcerative colitis. In indeterminate colitis, preoperative measurement of serological antibodies can help to predict the likelihood of complications among patients undergoing pouch surgery. The combined presence and magnitude of a large panel of antibodies appear to be of value in predicting disease progression. There is currently insufficient evidence to recommend the use of antibody testing to predict responses to treatment or surgery in patients with IBD.

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Section: Disease Stratification and Prediction In Ucmentioning

confidence: 99%

Serological Antibodies in Inflammatory Bowel Disease: A Systematic Review

Prideaux

Cruz

et al. 2012

Inflammatory Bowel Diseases

174

148

View full text Add to dashboard Cite

show abstract

“…Several studies showed that the presence of the diseased organ is not necessary for the presence of ANCA in the serum from patients with UC. ANCA were detected after colectomy [ 58–60], although in some studies titres declined [ 61]. An association was reported between ANCA and the development of pouchitis in patients with UC who underwent surgery [ 60, 62, 63], but more recent studies failed to confirm this association [ 64, 65].…”

Section: Clinical Significance Of Anca In Ibdmentioning

confidence: 99%

Are anti-neutrophil cytoplasmic antibodies (ANCA) clinically useful in inflammatory bowel disease (IBD)?

Roozendaal¹,

Kallenberg²

1999

Clinical and Experimental Immunology

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SUMMARYSince the first detection of ANCA in IBD, numerous studies have dealt with their prevalence, antigenic specificities, clinical significance, pathophysiological role, and their induction. This review summarizes the information obtained from those studies and shows that ANCA are not directly useful as diagnostic and prognostic factors in IBD. ANCA were detected in 50-85% of patients with ulcerative colitis (UC) and 10-20% of patients with Crohn's disease (CD). Multiple target antigens are recognized by these autoantibodies, including both cytoplasmic and nuclear proteins. A pathophysiological role for ANCA in IBD is far from clear. On the one hand, it is suggested that ANCA are genetic markers of susceptibility for IBD, and on the other hand, the induction of ANCA in those diseases may just be an epiphenomenon of chronic inflammation. We discuss recent evidence that ANCA may be induced by a break-through of tolerance towards bacterial antigens.

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“…The pANCA-positive status usually remains stable in human patients, even with clinical improvement. 15 In a study of ulcerative colitis patients by Patel et al, 22 pANCA-positive status was stable for 2 years after initiation of therapy. It would be unusual for the pANCA status in a patient with Crohn's disease to change from negative to positive.…”

Section: Discussionmentioning

confidence: 97%

Perinuclear Antineutrophilic Cytoplasmic Antibody and Response to Treatment in Diarrheic Dogs with Food Responsive Disease or Inflammatory Bowel Disease

Luckschander

Allenspach

Hall

et al. 2006

Veterinary Internal Medicne

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The goal of this study was to investigate the correlation between perinuclear antineutrophilic cytoplasmic antibody (pANCA) and clinical scores before and after treatment in diarrheic dogs with food-responsive disease (FRD) or inflammatory bowel disease (IBD). pANCA serology was evaluated prospectively by indirect immunofluorescence in 65 dogs with signs of gastrointestinal disease, and if positive, pANCA antibody titers were determined. Thirty-nine dogs with FRD responded to a novel diet, and 26 dogs with IBD were treated with corticosteroids. The severity of clinical signs was scored by means of a canine IBD activity index (CIBDAI). At initial examination, a significantly (P 5 .002) higher percentage of dogs were pANCA-positive in the FRD group (62%) compared with the IBD group (23%). pANCA titers were significantly higher (P 5 .003) before treatment in the FRD group (median titer 100) compared with the IBD group (median titer 1). However, there was no difference in pANCA titers between the groups after respective treatments because dogs in the IBD group had a significant increase in pANCA titer after treatment. The CIBDAI score decreased significantly (P , .001) after treatment in both groups (74% moderate to severe in FRD dogs before versus 8% after treatment; 85% moderate to severe in IBD dogs before versus 32% after treatment). There was no correlation between pANCA status in FRD or IBD dogs before treatment and scores for CIBDAI, endoscopy, or histopathology before or after treatment, except for the endoscopic duodenal score in dogs with FRD after treatment (P 5 .03). A positive pANCA test before therapy may aid in the diagnosis of FRD.

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Influence of total colectomy on serum antineutrophil cytoplasmic antibodies in inflammatory bowel disease

Cited by 49 publications

References 19 publications

Serological Antibodies in Inflammatory Bowel Disease: A Systematic Review

Serological Antibodies in Inflammatory Bowel Disease: A Systematic Review

Are anti-neutrophil cytoplasmic antibodies (ANCA) clinically useful in inflammatory bowel disease (IBD)?

Perinuclear Antineutrophilic Cytoplasmic Antibody and Response to Treatment in Diarrheic Dogs with Food Responsive Disease or Inflammatory Bowel Disease

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