Influence of tobacco smoke on zinc, cadmium, iron, iron-binding proteins, and low-weight anti-oxidant status in pregnancy

Milnerowicz, Halina; Wrześniak, Marta; Królik, Małgorzata; Kowalska, Katarzyna

doi:10.1080/08958378.2019.1576805

Cited by 4 publications

(8 citation statements)

References 55 publications

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“…A similar effect of exposure to tobacco smoke on higher MT concentration in the blood of pregnant women with intrauterine growth restriction was observed in our earlier study [1]. In addition, we revealed in a previous study that MT concentration in the first trimester was lower when compared to the third trimester [30]. The kind of exposure to tobacco smoke (passive or active smoking) during pregnancy did not influence MT concentration either in plasma and lysate or plasma SOD activity, whereas exposure to tobacco smoke during pregnancy resulted in a higher MT concentration and SOD activity.…”

Section: Discussionsupporting

confidence: 90%

“…Reduced concentration of GSH was also observed by other authors when exposure to tobacco smoke occurs [58] or during pregnancy, which was explained by oxidative stress and increases in plasma volume [59]. Unfortunately, when we evaluated the effect of exposure to tobacco smoke in each trimester of pregnancy in our previous study, we did not reveal any significant differences between non-smoking and smoking pregnant women [30].…”

Section: Discussionmentioning

confidence: 46%

“…Alterations in nonenzymatic and enzymatic antioxidants during pregnancy was demonstrated in many investigations. Changes in MT concentration could be associates with disorders in homeostasis of Zn and Cu as well as detoxification of Cd both in maternal and umbilical cord blood, which could negatively affect the fetus development [1,29,30]. The drop in SOD activity was found during pregnancy complicated by preeclampsia [31], IUGR (1), in the blood of women with recurrent miscarriage [14] or missed abortion [32].…”

Section: Introductionmentioning

confidence: 99%

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The Impact of Early Pregnancy and Exposure to Tobacco Smoke on Blood Antioxidant Status and Copper, Zinc, Cadmium Concentration—A Pilot Study

et al. 2021

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The aim of the study was to evaluate the impact of early pregnancy and exposure to tobacco smoke on antioxidant status and copper, zinc, and cadmium concentrations in the blood of non-smoking and smoking, as well as non-pregnant or pregnant women. The study included 213 women. More specifically, 150 women in first trimester of pregnancy and 63 non-pregnant women. Women were divided into subgroups according to exposure to tobacco smoke. Pregnancy significant influences higher copper and lower zinc concentration in the serum, whereas exposure to tobacco smoke during pregnancy is mainly associated with an elevation in cadmium and zinc concentration. It seems that metallothionein, superoxide dismutase, and glutathione peroxidase are the important antioxidants during early pregnancy, when exposure to tobacco smoke occurs, whereas the pregnancy itself is associated with a higher concentration of metallothionein and activity of catalase. Both pregnancy in the first trimester and exposure to tobacco smoke decrease glutathione concentration. In addition, active and passive maternal smoking have a similarly negative effect on antioxidant status in the first trimester. Early pregnancy as well as exposure to tobacco smoke is associated with significant alteration in antioxidant status and copper, zinc, and cadmium concentration. Due to a small number of smoking subjects (11 cases of non-pregnant, active smokers and 14 pregnant active smokers), the obtained results should be treated as a pilot, and this should be considered for future studies.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 46%

Section: Introductionmentioning

confidence: 99%

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The Impact of Early Pregnancy and Exposure to Tobacco Smoke on Blood Antioxidant Status and Copper, Zinc, Cadmium Concentration—A Pilot Study

et al. 2021

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“…There are only a few studies on the influence of smoking during pregnancy on maternal and child glutathione status, and the results were inconclusive. Our research has confirmed the results of other authors who showed no differences between the levels of reduced glutathione in the blood of pregnant smokers and non-smokers [ 20 , 35 ]. There are also reports of a negative effect of tobacco smoke on the levels of this compound during gestation [ 9 , 21 ].…”

Section: Discussionsupporting

confidence: 93%

Influence of Oxidative Stress Generated by Smoking during Pregnancy on Glutathione Status in Mother-Newborn Pairs

Chełchowska¹,

Gajewska²,

Ambroszkiewicz³

et al. 2021

Antioxidants

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Glutathione plays a key role in maintaining a physiological balance between prooxidants and antioxidants in the human body. Therefore, we examined the influence of maternal smoking as a source of oxidative stress measured by total oxidant capacity (TOC) on reduced glutathione (GSH), oxidized glutathione (GSSG), glutathione peroxidase (GPx-3), and reductase (GR) amount in maternal and umbilical cord blood in 110 (45 smoking and 65 non-smoking) mother-newborn pairs. Concentrations of glutathione status markers and TOC were evaluated by competitive inhibition enzyme immunoassay technique. Plasma TOC levels were significantly higher and the GSH/GSSG ratio, which is considered an index of the cell’s redox status, were significantly lower in smoking women and their offspring than in non-smoking pairs. Decreased GR levels were found in smoking mothers and their newborns compared with similar non-smoking groups. Although plasma GPx-3 concentrations were similar in both maternal groups, in the cord blood of newborns exposed to tobacco smoke in utero they were reduced compared with the levels observed in children of tobacco abstinent mothers. Oxidative stress generated by tobacco smoke impairs glutathione homeostasis in both the mother and the newborn. The severity of oxidative processes in the mother co-existing with the reduced potential of antioxidant systems may have a negative effect on the oxidative-antioxidant balance in the newborn.

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“…ROS interfere with the pro and antioxidant balance, as well as the mineral Zn balance and iron control. 23 This study discovered a strong relationship between pregnant women's serum zinc levels and their FFQ-Zn measured zinc intake. Pregnant women with high serum Zn levels have high Zn consumption.…”

Section: Discussionmentioning

confidence: 81%

The Role of Zinc-Rich Food Consumption on Zinc Level and the Incident of Preeclampsia

Hartono

Lukas²,

Mappaware³

et al. 2023

Obgynia

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Objective: Investigate the correlation between dietary intake of zinc, preeclampsia and blood zinc levels. Methods: This study, which compared pregnant women in the third trimester at the Wahidin Sudirohusodo Hospital and the educational network hospital with and without preeclampsia, used a Cross Sectional methodology. Zinc level testing was carried out at Prodia using ICP-MS method. Mann Whitney, Kruskal Wallis, and chi square tests were used to examine the data. Results: Preeclampsia group (n=38) and control group (n=40) were two groups made up of a total of 78 pregnant women. Zn level of severe preeclampsia (47.73 ± 11.23 ng/mL) was lower than preeclampsia (50.50 ± 13.59 ng/mL) and non-preeclampsia (50.58 ± 10.12ng/mL), but not significantly. Lower zinc rich-food consumption was a significant effect on zinc deficiency (p< 0.05), and was no significant effect on preeclampsia (p > 0.05). Conclusion: Low intake of zinc-rich foods and occasionally exposure to cigarette smoke are the causes of zinc insufficiency in third trimester pregnancy, but has little impact on the occurrence of preeclampsia. Peranan Konsumsi Makanan Kaya Zink terhadap Kadar Zink dan Insiden Preeklamsia Abstrak Tujuan: Mengetahui korelasi antara asupan zink, preeklamsia dan tingkat zink serum. Metode: Penelitian ini membandingkan ibu hamil trimester III di RS Wahidin Sudirohusodo dan RS jejaring pendidikan dengan dan tanpa preeklampsia menggunakan metodologi Cross Sectional. Pengujian kadar zink dilakukan di Prodia dengan menggunakan metode ICP-MS. Uji Mann Whitney, Kruskal Wallis dan Chi Square digunakan untuk menganalisis data. Hasil: Kelompok preeklamsia (n=38) dan kelompok kontrol (n=40) adalah dua kelompok yang terdiri dari total 78 ibu hamil. Kadar Zn preeklamsia berat (47.73 ± 11.23 ng/mL) lebih rendah dibandingkan preeklamsia (50.50 ± 13.59 ng/mL) dan non preeklamsia (50.58 ± 10.12ng/mL), tetapi tidak bermakna. Rendahnya konsumsi makanan kaya zink berpengaruh signifikan terhadap defisiensi zink (p<0.05), namun tidak signifikan terhadap kejadian preeklamsia (p>0.05). Kesimpulan: Diet rendah zink dan paparan asap rokok adalah penyebab defisiensi zink pada kehamilan trimester III, tetapi memiliki dampak kecil terhadap insiden preeklamsia. Kata kunci: preeklamsia, kehamilan, zink

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Influence of tobacco smoke on zinc, cadmium, iron, iron-binding proteins, and low-weight anti-oxidant status in pregnancy

Cited by 4 publications

References 55 publications

The Impact of Early Pregnancy and Exposure to Tobacco Smoke on Blood Antioxidant Status and Copper, Zinc, Cadmium Concentration—A Pilot Study

The Impact of Early Pregnancy and Exposure to Tobacco Smoke on Blood Antioxidant Status and Copper, Zinc, Cadmium Concentration—A Pilot Study

Influence of Oxidative Stress Generated by Smoking during Pregnancy on Glutathione Status in Mother-Newborn Pairs

The Role of Zinc-Rich Food Consumption on Zinc Level and the Incident of Preeclampsia

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