Influence of Thyroid Status on Chylomicron Triacylglycerol Metabolism in Sedentary and Trained Rats

Zernicka, E; Budohoski, L; Langfort, Józef; Nazar, K; Kaciuba-Uściłko, H.

doi:10.1042/cs087s096

Cited by 2 publications

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“…These results are similar to those from an earlier study employing the same model of hypothyroidism and showing augmentation of plasma FA level by 45% and a 50% reduction of plasma TG concentration [45]. This pattern of changes in blood TG and FA concentration in rats with a T 3 deficit results probably from a highly enhanced rate of lipoprotein TG hydrolysis, as under these conditions the activity of lipoprotein lipase (LPL) is increased markedly both in adipose tissue [31] and skeletal muscles [21,27,45]. Additionally, the high activity of LPL is not associated with enhanced uptake of FA released from TG-chylomicrons in vivo [21].…”

Section: Discussionsupporting

confidence: 94%

“…i.p. daily, as in previous studies [13,45]. These procedures lead to a threefold decrease in circulating T 3 in THY rats and a ninefold increase in T3 animals [13].…”

Section: Animal Protocolsmentioning

confidence: 67%

“…There are, however, only few data on the role of thyroid hormones on lipid metabolism in skeletal muscle. The activity of lipoprotein lipase (LPL), the rate-limiting enzyme for the hydrolysis of plasma TG present in circulating lipoproteins, increases in skeletal muscle of rats with experimental hypothyroidism [21,45] and decreases in hyperthyroid rats [21,45]. Although hypothyroidism is thought to reduce intramuscular TG content [21], other studies have failed to demonstrate this effect [45].…”

Section: Introductionmentioning

confidence: 96%

“…The activity of lipoprotein lipase (LPL), the rate-limiting enzyme for the hydrolysis of plasma TG present in circulating lipoproteins, increases in skeletal muscle of rats with experimental hypothyroidism [21,45] and decreases in hyperthyroid rats [21,45]. Although hypothyroidism is thought to reduce intramuscular TG content [21], other studies have failed to demonstrate this effect [45]. On the other hand, in hyperthyroidism an increased TG content has been described in skeletal muscle [21,44] and, moreover, thyroid hormone excess affects the rate of FA incorporation into PL and the content of PL in skeletal muscle cell membranes [35,44].…”

Section: Introductionmentioning

confidence: 99%

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Palmitic acid metabolism in the soleus muscle in vitro in hypo- and hyperthyroid rats

Górecka

Synak

Langfort

et al. 2004

Pflugers Arch - Eur J Physiol

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The aim of this study was to establish whether the rate of fatty acid (FA) incorporation and its utilization by the isolated soleus muscle is modified under conditions of thyroid hormone deficit or excess. The rate of palmitic acid (PA) uptake, oxidation and incorporation into intramuscular lipids with increasing PA concentration (0.5-1.5 mM) in the incubation medium were determined. In hypothyroid rats intramuscular triacylglycerol (TG) synthesis was increased, while the rate of PA oxidation to CO2 and incorporation into mono- and diacylglycerols (MG/DG) and phospholipids (PL) remained unchanged. In rats with triiodothyronine (T3) excess the rate of all processes studied was enhanced, although the percentage incorporation of PA into different classes of intramuscular lipids was fairly constant and, independently of thyroid state and FA concentration in the medium, was 56-66% for TG, 9-14% for MG/DG and 24-32% for PL. Our results thus indicate that even short-term T3 excess accelerates the rate of FA uptake and metabolism in the oxidative soleus muscle, whereas in hypothyroid rats only intramuscular TG synthesis is affected.

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Section: Discussionsupporting

confidence: 94%

“…i.p. daily, as in previous studies [13,45]. These procedures lead to a threefold decrease in circulating T 3 in THY rats and a ninefold increase in T3 animals [13].…”

Section: Animal Protocolsmentioning

confidence: 67%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Palmitic acid metabolism in the soleus muscle in vitro in hypo- and hyperthyroid rats

Górecka

Synak

Langfort

et al. 2004

Pflugers Arch - Eur J Physiol

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Effect of triiodothyronine (T₃) excess on fatty acid metabolism in the soleus muscle from endurance-trained rats

Górecka

Synak

Brzezińska

et al. 2016

Biochem. Cell Biol.

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We studied whether short-term administration of triiodothyronine (T3) for the last 3 days of endurance training would influence the rate of uptake of palmitic acid (PA) as well as metabolism in rat soleus muscle, in vitro. Training per se did not affect the rate of PA uptake by the soleus; however, an excess of T3 increased the rate of this process at 1.5 mmol/L PA, as well as the rate that at which PA was incorporated into intramuscular triacylglycerols (TG). The rate of TG synthesis in trained euthyroid rats was reduced after exercise (1.5 mmol/L PA). The rate of PA oxidation in all of the trained rats immediately after exercise was enhanced by comparison with the sedentary values. Hyperthyroidism additionally increased the rate of this process at 1.5 mmol/L PA. After a recovery period, the rate of PA oxidation returned to the control values in both the euthyroid and the hyperthyroid groups. Examination of the high-energy phosphate levels indicated that elevated PA oxidation after exercise-training in euthyroid rats was associated with stable ATP levels and increased ADP and AMP levels, thus reducing energy cellular potential (ECP). In the hyperthyroid rats, levels of ADP and AMP were increased in the sedentary as well as the exercise-trained rats. ECP levels were high as a result of high levels of ATP and decreased levels of ADP and AMP in hyperthyroid rats after the recovery period. In conclusion, short-term hyperthyroidism accelerates PA utilization in well-trained soleus muscle.

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Influence of Thyroid Status on Chylomicron Triacylglycerol Metabolism in Sedentary and Trained Rats

Cited by 2 publications

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Palmitic acid metabolism in the soleus muscle in vitro in hypo- and hyperthyroid rats

Palmitic acid metabolism in the soleus muscle in vitro in hypo- and hyperthyroid rats

Effect of triiodothyronine (T₃) excess on fatty acid metabolism in the soleus muscle from endurance-trained rats

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Influence of Thyroid Status on Chylomicron Triacylglycerol Metabolism in Sedentary and Trained Rats

Cited by 2 publications

References 0 publications

Palmitic acid metabolism in the soleus muscle in vitro in hypo- and hyperthyroid rats

Palmitic acid metabolism in the soleus muscle in vitro in hypo- and hyperthyroid rats

Effect of triiodothyronine (T3) excess on fatty acid metabolism in the soleus muscle from endurance-trained rats

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Effect of triiodothyronine (T₃) excess on fatty acid metabolism in the soleus muscle from endurance-trained rats