Influence of Thyroid Hormones and Transforming Growth Factor-β1 on Cystatin C Concentrations

Kotajima, Nobuo; Yanagawa, Yoshimaro; Aoki, Tomoyuki; Tsunekawa, Katsuhiko; Morimura, Tadashi; Ogiwara, Takayuki; Nara, Makoto; Murakami, Masami

doi:10.1177/147323001003800418

Cited by 35 publications

(35 citation statements)

References 26 publications

(20 reference statements)

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“…The study subjects were almost all patients with native kidney disease, so it may not be possible to generalize the results to healthy subjects. It has been reported that cystatin C levels were influenced by factors other than GFR, such as thyroid function [14,15], inflammation [5,6], smoking [6,8] and immunosuppressive therapy [16]. Multivariate analysis was not adjusted for the above factors in the present study.…”

Section: Discussionmentioning

confidence: 75%

Performance of serum cystatin C versus serum creatinine as a marker of glomerular filtration rate as measured by inulin renal clearance

et al. 2011

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Section: Discussionmentioning

confidence: 75%

Performance of serum cystatin C versus serum creatinine as a marker of glomerular filtration rate as measured by inulin renal clearance

et al. 2011

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“…Serum concentrations of TGFb1 were higher in patients with Graves' disease compared to controls and decreased after treatment for hyperthyroidism. Positive correlations were observed between thyroid hormones and TGFb1 in patients with thyroid dysfunction [55]. Endocrine glands are well vascularised and the structure of their vessels (fenestration of epithelium) facilitates the exchange of various substances, including hormones.…”

Section: Discussionmentioning

confidence: 95%

Transformujący czynnik wzrostu β1 (TGFβ1) i naczyniowo-śródbłonkowy czynnik wzrostu (VEGF) we krwi ludzi zdrowych i chorych z orbitopatią Gravesa — nowy mechanizm działania glikokortykosteroidów?

Kajdaniuk¹,

Marek²,

Niedziołka-Zielonka³

et al. 2014

Endokrynologia Polska

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“…These capabilities have made it an attractive marker for estimating glomerular filtration [12-15]. However, the receipt of glucocorticoids, thyroid function, inflammation and obesity, rather than sex or age, may affect the measurement of serum CysC[16-18]. Recent studies have further suggested that serum CysC (sCysC) may be an early predictor for AKI and the prognosis of patients in cardiac surgery [19-22], intensive care [23, 24], radiocontrast administration settings [25] and emergency departments [26].…”

Section: Introductionmentioning

confidence: 99%

Serum Cystatin C Predicts AKI and the Prognosis of Patients in Coronary Care Unit: a Prospective, Observational Study

Hu¹,

Liu²,

Du³

et al. 2017

Kidney Blood Press Res

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Background/Aims: Acute Kidney Injury (AKI) is a serious clinical state associated with high morbidity and mortality, particularly in critical ill patients. We investigated the hypothesis that serum Cystatin C (sCysC) is a good predictor for AKI and may affect the short-term prognosis of coronary care unit (CCU) patients. Methods: In this prospective, observational study, we screened 412 adults admitted to the CCU from January 1, 2014 to June 1, 2015 at Zhongnan Hospital of Wuhan University. Serum samples were obtained at the time of admission, and sCysC was quantified through nephelometry. AKI was defined based on KDIGO-AKI criteria. After the patients’ hospital discharge, the survivors in this study were followed up for up to 2 years. The primary endpoint was the incidence of AKI stratified by severity stage, while the second endpoints included 2-year mortality, rehospitalization and failure in renal recovery rates, as well as the progression of AKI to CKD. Results: According to the KDIGO-AKI criteria, AKI occurred in 130 (31.6%) patients. After multivariate adjustments, the highest quartile of sCysC was associated with a 9-fold increased risk of incident AKI compared with the lowest quartile. For predicting AKI, sCysC [area under the receiver operating characteristic curve (AUC=0.842)] outperformed β2-micro globulin (AUC=0.813) and the clinical model (AUC=0.777), and a cutoff of 1.255 mg/L yielded good sensitivity and specificity. After a median 19.8-month follow-up, 112 (27.2%) patients died within 2 years after admission. The sCysC independently predicted the risk of 2-year mortality [adjusted odds ratio (OR), 4.955; 95% confidence interval (95% CI), 2.853 to 8.603] and rehospitalization (OR, 3.128; 95% CI, 2.011 to 4.867), as well as renal recovery failure (OR, 3.618, 95% CI, 1.753 to 7.463). Conclusions: Serum CysC is a strong predictor of AKI and the short-term prognosis of CCU patients.

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Influence of Thyroid Hormones and Transforming Growth Factor-β1 on Cystatin C Concentrations

Cited by 35 publications

References 26 publications

Performance of serum cystatin C versus serum creatinine as a marker of glomerular filtration rate as measured by inulin renal clearance

Performance of serum cystatin C versus serum creatinine as a marker of glomerular filtration rate as measured by inulin renal clearance

Transformujący czynnik wzrostu β1 (TGFβ1) i naczyniowo-śródbłonkowy czynnik wzrostu (VEGF) we krwi ludzi zdrowych i chorych z orbitopatią Gravesa — nowy mechanizm działania glikokortykosteroidów?

Serum Cystatin C Predicts AKI and the Prognosis of Patients in Coronary Care Unit: a Prospective, Observational Study

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