Influence of thyroid function on the blood clotting system

Vuopio, P

doi:10.3109/00365516309051302

Cited by 76 publications

(23 citation statements)

References 11 publications

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“…As regards the coagulation-fibrinolytic abnormalities in overt hypothyroidism, Egeberg (27) and Simone et al (28) also documented a significant reduction in coagulation factors VIII, IX, and XI activities in hypothyroid patients. Further small case-control studies (29)(30)(31), although not all (32,33), confirmed these findings and also reported lower levels of plasma coagulation factors VII, X, and XII in hypothyroid patients.…”

Section: Hypothyroidismmentioning

confidence: 99%

Hemostatic abnormalities in endocrine and metabolic disorders

Franchini¹,

Lippi²,

Manzato³

et al. 2010

European Journal of Endocrinology

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The hemostatic balance is a complex system where the delicate equilibrium is regulated by several factors, including hormones. This review summarizes current knowledge of the effects of most frequent endocrine and metabolic diseases (such as hypothyroidism, hyperthyroidism, Cushing's syndrome, GH-related pituitary dysfunctions, pituitary prolactin-producing adenomas, polycystic ovary syndrome, primary hyperparathyroidism, and metabolic syndrome) on coagulation and fibrinolysis. Overt hypothyroidism appears to be associated with a bleeding tendency, whereas all other endocrine diseases appear to be associated with a thrombotic tendency. Globally, the disorders of coagulation and fibrinolysis usually range from mild to moderate, and, rarely, to severe laboratory abnormalities (for example, bleeding diathesis in overt hypothyroidism mainly due to an acquired von Willebrand's disease type 1). Further larger and high-quality studies are needed to provide more definitive information on the effects of endocrine disorders on coagulation and fibrinolysis.

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Section: Hypothyroidismmentioning

confidence: 99%

Hemostatic abnormalities in endocrine and metabolic disorders

Franchini¹,

Lippi²,

Manzato³

et al. 2010

European Journal of Endocrinology

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“…Bleeding symptoms, such as easy bruising, menorrhagia and sometimes even a severe bleeding tendency with fatal outcome, have been observed for many years in patients with hypothyroidism (Orr, 1962;Egeberg, 1963). Hypothyroidism has been reported to be a cause of acquired von Willebrand's disease and of prolonged bleeding after tooth (Received 14 September 1994; returned for revision 9 November 1994; finally revised 12 December 1994; accepted 9 January 1995) Summary OBJECTIVE Hypothyroldlsm can be compllcated by bleeding symptoms such as easy brulslng, menorrhagla and sometlmes even a severe bleedlng tendency wlth fatal outcome.…”

mentioning

confidence: 99%

Effect of acute desmopressin and of long‐term thyroxine replacement on haemostasis in hypothyroidism

Erfurth

Ericsson

Egervall

et al. 1995

Clinical Endocrinology

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Summary OBJECTIVE Hypothyroidism can be complicated by bleeding symptoms such as easy bruising, menorrhagla and sometimes even a severe bleeding tendency with fatal outcome. Usually there is a prolonged bleeding time, or a low plasma concentration of coagulation factor VIII (FVIII) or von Willebrand factor (vWF). The aim of the present study was to investigate the acute haemostatic effect of desmopressin in hypothyroid patients. Another aim was to study the long‐term effect of thyroxine replacement on the plasma concentrations of coagulation factors and to ascertain the duration of thyroxine treatment needed to restore haemostatic function. DESIGN AND PATIENTS The effects of desmopressin, given intravenously over 10 minutes at a dosage of 0.3 μg/kg, and thyroxine treatment on haemostatic function were studied prospectively In 10 patients with hypothyroidism. RESULTS Before treatment only five of the patients manifested bleeding symptoms; one had prolonged bleeding time, and one had low plasma concentrations of vWF: Ag. Desmopressin virtually immediately reduced bleeding time, enhanced platelet adhesiveness, and significantly increased plasma concentrations of FVIII and vWF. The plasma concentrations of FVIII and vWF showed a significant increase after 4 months, whereas 7 months treatment with thyroxine was needed to reduce bleeding time significantly. CONCLUSION Our results suggest that in hypothyroid patients desmopressin may be of value for the acute treatment of bleeding or as cover for surgery.

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“…Abnormalities of coagulation and fi brinolysis have been reported in associa tion with thyroxine deficiency [1,2]. In most instances reduced levels of clotting factors have been modest and only rarely have these changes been associated with haemorrhagic problems.…”

Section: Commentmentioning

confidence: 99%

“…This contrasts with a previously reported case in which both thyroxine and cortisone were required for complete correction of the factor IX deficiency. The under lying mechanism and the consequencies are briefly discussed.The occurence of coagulation abnor malities in hypothyroid and hypopituitary states is well recognised [1,2], However, reports of clinically significant bleeding tendency are rare. We report a case of pi tuitary insufficiency presenting with haemorrhage following dental extraction, found to be due to factor IX deficiency.…”

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confidence: 99%

Haemorrhage and Factor IX Deficiency in Pituitary Insufficiency

Woodcock¹,

Preston²

1983

Acta Haematol

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Acquired isolated factor IX deficiency is rare. A case presenting with haemorrhage after dental extraction is described. The factor IX deficiency was associated with pituitary insufficiency and was completely corrected following the administration of thyroxine. This contrasts with a previously reported case in which both thyroxine and cortisone were required for complete correction of the factor IX deficiency. The underlying mechanism and the consequencies are briefly discussed.

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Influence of thyroid function on the blood clotting system

Cited by 76 publications

References 11 publications

Hemostatic abnormalities in endocrine and metabolic disorders

Hemostatic abnormalities in endocrine and metabolic disorders

Effect of acute desmopressin and of long‐term thyroxine replacement on haemostasis in hypothyroidism

Haemorrhage and Factor IX Deficiency in Pituitary Insufficiency

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