Influence of the valve on the performance of two cylindrical valved holding chambers

Charras, Yamila L. de; Bertin, Diego Esteban; Ramírez-Rigo, María Verónica

doi:10.1016/j.powtec.2022.118094

Cited by 2 publications

(7 citation statements)

References 30 publications

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“…Low velocity zones are found downstream of the valve both in the centre of the VHC and near the walls. As reported by de Charras et al [6] for a similar VHC, regions of air recirculation are associated with low velocity zones.…”

Section: Cfd Simulation Resultssupporting

confidence: 74%

“…In addition, the impactor plates were coated with a solution of polysorbate 80 in 1% (w/v) ethanol to mitigate the particle rebound effect. [6] During the experiments, the pMDI or VHC was connected to the IP of the NGI using a mouthpiece adapter (MA). Following the procedure of de Charras et al, [6] 10 doses per test were discharged in each trial to ensure an adequate analytical determination.…”

Section: Experimental Aerodynamic Characterizationmentioning

confidence: 99%

“…[6] During the experiments, the pMDI or VHC was connected to the IP of the NGI using a mouthpiece adapter (MA). Following the procedure of de Charras et al, [6] 10 doses per test were discharged in each trial to ensure an adequate analytical determination. Additionally, the pMDI was shaken for 5 s between each performance.…”

Section: Experimental Aerodynamic Characterizationmentioning

confidence: 99%

“…In case I, the inlet velocity of the particles was set at 40 m/s and the cone angle was 8 , which correspond to those of the spray generated by the pMDI. [6,42] In case II, because the particles come from the VHC, it was assumed that the particles have the same speed and direction as the inlet air. The outer radius of the conical injection was 0.005 m in both cases.…”

Section: Particle Simulationmentioning

confidence: 99%

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Aerosol deposition and emission from a United States Pharmacopeia‐induction port when using a pressurized metered‐dose inhaler with and without a valved holding chamber

de Charras,

Ramírez Rigo,

Bertin

2024

Can J Chem Eng

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The testing of pharmaceutical aerosols includes measuring the aerodynamic particle size distribution, which is usually performed on cascade impactors. In the next generation impactor (NGI), the aerosol dose is introduced through an induction port (IP), being separated into different aerodynamic diameter ranges by seven stages and a micro‐orifice collector. The IP plays an important role in estimating the oropharyngeal deposition fraction. While the IP retains mainly large particles, it also tends to retain particles in the respirable range. In this work, the deposition of particles in the IP of an NGI is studied, both experimentally and through computational fluid dynamic (CFD) simulations. Experimental tests are conducted both with the pressurized metered‐dose inhaler (pMDI) alone and in conjunction with a cylindrical valved holding chamber (VHC). For each case, the total mass deposition that occurs in the VHC, IP, and NGI stages is measured, as well as the mass median aerodynamic diameter of the aerosol leaving the IP. The CFD simulations show minimal variations in results regardless of the injection method due to the relatively low velocity and spray angle of the pMDI‐generated aerosol. If the flap‐valve is removed from the VHC, significant particle deposition occurs upstream or within the valve region, with downstream air recirculation contributing to small particle deposition. Based on the CFD results, a correlation is proposed to accurately predict the particle escape fraction of the IP and VHC, which allows estimation of the tannin distribution of particles collected in the NGI stages, especially those corresponding to the range of respirable particles.

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Section: Cfd Simulation Resultssupporting

confidence: 74%

Section: Experimental Aerodynamic Characterizationmentioning

confidence: 99%

Section: Experimental Aerodynamic Characterizationmentioning

confidence: 99%

Section: Particle Simulationmentioning

confidence: 99%

See 2 more Smart Citations

Aerosol deposition and emission from a United States Pharmacopeia‐induction port when using a pressurized metered‐dose inhaler with and without a valved holding chamber

de Charras,

Ramírez Rigo,

Bertin

2024

Can J Chem Eng

Self Cite

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show abstract

“…Therefore, a 10 cm distance was possible to deliver the particles to cells without causing negative influence on them by the unevaporated solvent. This distance is suitable for drug deposition in oral or nasal drug delivery since the distance for drug nebulization intake is approximately 10–20 cm. , The evaporation of solvent was also accelerated by the ion wind as seen in drying applications . The results show that our system can deliver particles to cells safely at a long distance by increasing the evaporation rate of solvent.…”

Section: Resultsmentioning

confidence: 99%

Charge-Reduced Particles via Self-Propelled Electrohydrodynamic Atomization for Drug Delivery Applications

Yadav

Tran

et al. 2023

ACS Appl. Mater. Interfaces

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Electrohydrodynamic atomization (EHDA) provides unparalleled control over the size and production rate of particles from solution. However, conventional methods produce highly charged particles that are not appropriate for inhalation drug delivery. We present a self-propelled EHDA system to address this challenge, a promising one-step platform for generating and delivering charge-reduced particles. Our approach uses a sharp electrode to produce ion wind, which reduces the cumulative charge in the particles and transports them to a target in front of the nozzle. We effectively controlled the morphologies of polymer products created from poly(vinylidene fluoride) (PVDF) at various concentrations. Our technique has also been proven safe for bioapplications, as evidenced by the delivery of PVDF particles onto breast cancer cells. The combination of simultaneous particle production and charge reduction, along with its direct delivery capability, makes the self-propelled EHDA a versatile technique for drug delivery applications.

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Influence of the valve on the performance of two cylindrical valved holding chambers

Cited by 2 publications

References 30 publications

Aerosol deposition and emission from a United States Pharmacopeia‐induction port when using a pressurized metered‐dose inhaler with and without a valved holding chamber

Aerosol deposition and emission from a United States Pharmacopeia‐induction port when using a pressurized metered‐dose inhaler with and without a valved holding chamber

Charge-Reduced Particles via Self-Propelled Electrohydrodynamic Atomization for Drug Delivery Applications

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