Influence of the use of atypical antipsychotics in metabolic syndrome

Doménech-Matamoros, P

doi:10.18176/resp.00014

Cited by 9 publications

(5 citation statements)

References 28 publications

(53 reference statements)

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“…Mitigating metabolic health risks, such as poor cardiovascular health and obesity from shift work, may be significant for nurses with BSDs. Antipsychotics often used to treat BSDs may compound these adverse metabolic outcomes [36]. With an increasing nursing shortage, creating a supportive work environment for individuals struggling with mental and physical health is critical to prevent attrition [5].…”

Section: Discussionmentioning

confidence: 99%

Bipolar spectrum disorders among American registered nurses: a narrative literature review

Armijo

2023

Discov Psychol

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Background Bipolar spectrum disorders (BSDs) are serious psychiatric conditions correlated with high rates of suicide, substance misuse, hospitalization, and cardiometabolic diseases. Little is known about how BSDs affect American registered nurses (RNs) diagnosed with the condition. Purpose This review aimed to identify risk factors and socioeconomic impacts influencing American RNs diagnosed with BSDs. Methods The study examined literature in PubMed, CINAHL, PsycINFO, and SCOPUS. Articles discussing RNs diagnosed with BSDs were selected and evaluated for common risk factors and socioeconomic themes. Results Eight papers meeting the inclusion criteria were analyzed. Five articles were personal narratives, two were mixed methods, and one was a cohort study. Risk factors included gender, stress, shift work, and sleep. Socioeconomic themes included economic impact and subjective experience. The female gender predominated in the RN workforce and, to a lesser extent, BSDs. Stress was intertwined with shift work and sleep, as they all influenced circadian alterations, mania, depression, and substance use. The economic impact was poorly understood; however, identified elements were related to hospitalization, absenteeism, and preclusion from insurance coverage. Subjective experiences of RNs with BSDs indicated that stigma incited hostile work environments and shame while seeking mental health care. Conclusion The findings indicated that the identified risk factors contributed to adverse psychological, neurological, and cardiometabolic outcomes. Identified socioeconomic themes suggested unfavorable outcomes, including absenteeism, exclusion from insurance coverage, stigmatization, and hospitalization. However, there is a paucity of information, especially from high-quality studies. This novel review provides the foundation for future research.

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Section: Discussionmentioning

confidence: 99%

Bipolar spectrum disorders among American registered nurses: a narrative literature review

Armijo

2023

Discov Psychol

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“…Metabolic syndrome (MetS) is not a peripheral issue in the context of schizophrenia; rather, it is fundamentally intertwined with the disorder's complex pathology [15]. This intricate linkage necessitates an integrative treatment paradigm that encompasses not only psychiatric care but also addresses the metabolic challenges inherent to schizophrenia.…”

Section: Integrative Treatment Paradigm: Addressing Metabolic Syndrom...mentioning

confidence: 99%

“…Additionally, non-pharmacological interventions like specialized exercise programs and diet modifications have been proposed as valuable tools to offset the negative impact of MetS on cognitive outcomes in schizophrenia patients [15]. While the importance of a multi-disciplinary approach is increasingly recognized, a knowledge gap still persists concerning the relationship between MetS and cognitive functions in schizophrenia patients.…”

Section: Integrative Treatment Paradigm: Addressing Metabolic Syndrom...mentioning

confidence: 99%

Biopsychosocial Variables in Male Schizophrenic Patients: A Comprehensive Comparison with Healthy Controls

Krysta,

Trędzbor,

Martyniak

et al. 2023

Pharmaceuticals

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Objective: this study aims to comprehensively compare neuropsychological, psychopathological, anthropometric, biochemical, pharmacological, and lifestyle variables between 27 male schizophrenic patients (SZ group) and 30 age- and sex-matched healthy male controls (HC group). Methods: participants underwent a battery of neuropsychological tests including the Trail Making Test (TMT), Stroop Color-Word Interference Test, and Verbal Fluency Test. Psychopathological symptoms in the SZ group were evaluated using the Positive and Negative Syndrome Scale (PANSS). Anthropometric measurements such as body weight, height, BMI, and waist circumference were taken. Biochemical markers measured included fasting glucose, total cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, and fasting insulin. Lifestyle factors were assessed through a questionnaire for the study of views and eating habits of people aged 16 to 65. Results: the HC group outperformed the SZ group in the TMT_A test and the Stroop test, but no significant differences were observed in the TMT_B test or in phonemic fluency tests. No correlation was found between age and PANSS scores within the SZ group. Anthropometrically, the SZ group had higher body weight, waist circumference, and BMI, with no difference in height. Biochemically, the HC group had higher HDL cholesterol levels but lower insulin and insulin resistance indices. Pharmacological assessment showed a more significant impact on body weight among SZ patients taking second-generation antipsychotics. Lifestyle factors such as diet and screen time were comparable between groups, but the SZ group reported longer sleep duration and lower leisure time activity. Conclusions: our study highlights distinct neuropsychological, pharmacological, anthropometric, and biochemical differences between male schizophrenic patients and healthy controls. The results underscore the complexity of schizophrenia and point toward the need for a multi-faceted approach to its management and understanding.

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“…Apesar dos relatos de maior frequência de quadros de diabetes em pacientes que fazem uso de antipsicóticos atípicos, fazendo associação entre o fármaco e o desenvolvimento da comorbidade, existe a recomendação de se evitar a administração do fármaco nessa situação, pois além da diabetes, pode ocorrer o desenvolvimento de alterações metabólicas que predispõem o risco de uma síndrome metabólica, evoluindo para o aparecimento de mais comorbidades no paciente (Narváez et al, 2020;Doménech-Matamoros, 2020).…”

Section: Introductionunclassified

O desenvolvimento de diabetes mellitus com o uso crônico de antipsicóticos atípicos em pacientes do CAPS II, da cidade de Maringá-PR

Olivieri,

Vieira,

Ferreira

2023

RSD

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Esquizofrenia é uma doença crônica, de natureza multifatorial, prevalente em 1% da população mundial. O tratamento é realizado com antipsicóticos convencionais ou atípicos. A evolução no tratamento da esquizofrenia se deu com os antipsicóticos atípicos, pois eles oferecem menos efeitos e permitem uma atuação simultânea sobre os sintomas positivos e negativos da doença. Esses fármacos são usados tanto para o controle da esquizofrenia quanto de outras psicopatologias, por exemplo, o Transtorno Afetivo Bipolar (CID F31). As bulas dos medicamentos antipsicóticos alertam para o cuidado ao utilizar o medicamento em pacientes diabéticos ou que apresentem risco de desenvolver a diabetes, sendo recomendado o monitoramento glicêmico de tais pacientes. Em decorrência desse efeito, o presente trabalho tem como objetivo realizar um levantamento de informações a respeito do desenvolvimento de diabetes, em decorrência do uso de antipsicóticos atípicos para o tratamento de esquizofrenia, transtornos esquizotípicos, transtornos delirantes e outros transtornos que se assemelham à esquizofrenia. Essa é uma pesquisa descritiva, de análise quantitativa, com ênfase em dados bibliográficos e pesquisa de campo, na qual foram coletados dados, por meio de prontuários, com pacientes de área de abrangência do centro de atenção psicossocial (CAPS II), da cidade de Maringá-PR. Os resultados encontrados por meio desse estudo foram os efeitos colaterais dos fármacos, sua relação com idade, gênero, posologia e tempo de uso. Além disso, pode-se perceber a influência multifatorial para o desenvolvimento de outras comorbidades. Com isso, é possível contribuir para orientações adequadas, enfatizando os malefícios que a administração inadequada desses medicamentos pode gerar.

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Influence of the use of atypical antipsychotics in metabolic syndrome

Cited by 9 publications

References 28 publications

Bipolar spectrum disorders among American registered nurses: a narrative literature review

Bipolar spectrum disorders among American registered nurses: a narrative literature review

Biopsychosocial Variables in Male Schizophrenic Patients: A Comprehensive Comparison with Healthy Controls

O desenvolvimento de diabetes mellitus com o uso crônico de antipsicóticos atípicos em pacientes do CAPS II, da cidade de Maringá-PR

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