Influence of the size of nanostructured metals on changes in the functional state of the cell and biological activity

Abstract

The properties of nanostructured metals differ from the classical ones. The biological activity of nanoparticles is influenced by many factors, but primarily by concentration and size. It is urgent to study their interaction with living organisms, in particular plants, for which the main action is the realization of the genetic orientation of various varieties and hybrids, as well as the enhancement of the biosynthesis of biologically active compounds. The same biological effects are caused by nanoparticles of the same size, although the magnitude of their activity is different. It is assumed that these effects are due to the action of a certain regulatory response signal in biological systems. One of the responses may be changes in the structure of membranes that allow the passage of nanostructured particles, which can contribute to a change in the functional state of the cell. The magnitude of the response signal depends on the concentration of nanoparticles. The aim of this work is to study the effect of the size of nanostructured metals of various concentrations on the change in the functional state of the cell and the manifestation of biocompatibility and bioaccumulation in relation to nanoparticles.

Potential anti-osteoclastic and anti-inflammatory effects of metformin-encapsulated hyaluronic acid-decorated niosome nanoparticles: possible application for effective treatment of rheumatoid arthritis

“…The size of nanoparticles in uences their ability to overcome transport barriers in biological tissues, affecting their tissue penetration e cacy (58). Additionally, nanoparticle size impacts their biological activity, with factors like concentration and size playing primary roles (59). The DLS analysis showed that the blank niosome NPs had an average diameter of 151 ± 6.2 nm (Table 3).…”