Influence of the site of origin on the outcome of squamous cell carcinoma of the maxilla—oral versus sinus

Bobinskas, Alexander M.; Wiesenfeld, D.; Chandu, Arun

doi:10.1016/j.ijom.2013.09.008

Cited by 13 publications

(10 citation statements)

References 22 publications

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“…Bobinskas et al investigated in 2014 the influence of the site of origin on the outcome of SCC of the maxilla-oral versus sinus. 12 They found that maxillary sinus origin was associated with a poorer prognosis on univariate analysis, but this was not confirmed as an independent risk factor by multivariate analysis. Based on their results, they concluded that maxillary sinus origin is not a risk factor for a poorer prognosis itself, rather it is that these tumors are more likely to be advanced at the time of diagnosis and, due to the complex anatomy of the midface, are more likely to be incompletely resected.…”

Section: Kermer Et Al Reported 36 Patients With Primary Resectablementioning

confidence: 95%

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Squamous Cell Carcinoma of the Paranasal Sinuses: A Single Center Experience

König

Osnes

Bratland

et al. 2019

J Neurol Surg B Skull Base

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Objective Squamous cell carcinoma (SCC) of the paranasal sinuses is usually diagnosed at an advanced stage, making curative therapy difficult. The goal of this study was to evaluate the management and outcomes of patients with SCC treated at our institution. Methods In a population-based consecutive prospective cohort, we conducted an analysis of all patients treated for SCC between 1988 and 2017. Results A total of 72 patients were included, follow-up was 100%. Mean follow-up was 57 months for the entire cohort, and 108 months for patients with no evidence of disease. Eighty-two percent of all patients had high-stage (T4) disease. Fifty-seven patients underwent treatment with curative intent; consisting of surgery with or without oncologic treatment in 34, and of oncologic treatment only in 23 cases. Fifteen patients received palliative treatment. The rates of overall survival for the entire cohort were 55% at 2, 41% at 5, and 32% at 10 years, and corresponding disease-specific survival (DSS) rates were 55, 45, and 34%, respectively. DSS rates after surgical treatment with curative intent were 81% at 2, 65% at 5, and 54% at 10 years. Retromaxillary involvement and nonradical surgery were negative prognostic factors. Best survival was achieved with the combination of radical surgery and adjuvant oncologic treatment. Conclusion Surgical resection with a curative intent yielded 65% at 5-year DSS even in this cohort of patients with high-stage SCC and is still considered as the treatment of choice, preferably in combination with adjuvant radiation therapy and chemotherapy.

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Section: Kermer Et Al Reported 36 Patients With Primary Resectablementioning

confidence: 95%

“…Therefore, most patients present with advanced stage disease and have extensive involvement of adjacent sites at the time of diagnosis. [9][10][11][12][13][14][15] The tumor sites are usually in close proximity to the orbit, skull base, and the central nervous system, which present particular management difficulties.…”

Section: Introductionmentioning

confidence: 99%

Squamous Cell Carcinoma of the Paranasal Sinuses: A Single Center Experience

König

Osnes

Bratland

et al. 2019

J Neurol Surg B Skull Base

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“…5 Skull base metastases are more common and have an incidence of 18 per 100,000 per year. 6 The skull base can be invaded by malignancies originating from the sinonasal tract (esthesioneuroblastoma), 7 the nasopharynx (squamous cell carcinoma), 8 the oropharynx, the ear region, and the orbit (meningioma, osteoma, rhabdomyosarcoma). 5 …”

Section: General Classifications and Epidemiologymentioning

confidence: 99%

Surgical management of skull base tumors

Rangel-Castilla

Russin

Spetzler

2016

Reports of Practical Oncology & Radiotherapy

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“…Positive clinical N stage diagnosed based on the presence of cervical lymph node metastasis from clinical findings pre-surgery for SCC of the sinonasal tract leads to reduced rates of OS, and the rate of patients with SCC of the sinonasal tract and positive clinical N stage ranges from 3.3% to 36.7% [8][9][10][11]. Similarly, having positive surgical margins diagnosed by pathological findings following surgery for SCC of the sinonasal tract also leads to reduced rates of OS [2,5,[12][13][14][15][16] and the rate of positive surgical margins in patients with SCC of the sinonasal tract ranges from 10.5% to 63.5% [14][15][16][17]. Of note, among patients with SCC of the sinonasal tract, the 5-year OS rate among those with positive surgical margins (0% -32.8%) was significantly shorter than among those with negative surgical margins (65.7% -81.8%) [13,15,18].…”

Section: Introductionmentioning

confidence: 99%

Prediction of Positive Surgical Margins in Sinonasal Tract Squamous Cell Carcinoma

Hasegawa¹

2016

Arch Otolaryngol Rhinold

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Background: In patients with clinical T4 (cT4) squamous cell carcinoma (SCC) of sinonasal tract who received surgery, the relationship between positive surgical margins and positive clinical N stage as diagnosed by the presence of cervical lymph node metastasis has not been investigated so far. Therefore, we investigated the relationship between positive surgical margins and preoperative parameters in patients with cT4 SCC of the sinonasal tract following surgery. Methods: Forty-one patients who underwent surgery for cT4 SCC of the sinonasal tract were investigated and survival rates were calculated using the Kaplan-Meier method. The relationship between surgical margins and preoperative parameters was analyzed. Results: Both positive surgical margins and clinical N stage were significantly correlated with shorter survival rate by log-rank test. Conclusion: Positive surgical margins can be predicted based on clinical N stage in patients with cT4 SCC of the sinonasal tract.

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Influence of the site of origin on the outcome of squamous cell carcinoma of the maxilla—oral versus sinus

Cited by 13 publications

References 22 publications

Squamous Cell Carcinoma of the Paranasal Sinuses: A Single Center Experience

Squamous Cell Carcinoma of the Paranasal Sinuses: A Single Center Experience

Surgical management of skull base tumors

Prediction of Positive Surgical Margins in Sinonasal Tract Squamous Cell Carcinoma

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