Influence of the Sequence Motive Repeating Number on Protein Folding in Spider Silk Protein Films

Hofmaier, Mirjam; Heger, Julian E.; Lentz, Sarah; Schwarz, Simona; Müller-Buschbaum, Peter; Scheibel, Thomas; Fery, Andreas; Müller, Martin

doi:10.1021/acs.biomac.3c00688

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Functions Of Phosphoramidite Chemistry-based Sdps1

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2024

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“…The development of SDPs provides unprecedented opportunities for synthesized polymers to mimic the finely regulated assembly process of biopolymers. By accurately controlling the sequence and length of polymers, it is possible to regulate orthogonal and synergistic interactions within a single polymer, thereby directing their chain folding and interchain interactions with high specificity. , …”

Section: Functions Of Phosphoramidite Chemistry-based Sdpsmentioning

confidence: 99%

Advanced Smart Biomaterials for Regenerative Medicine and Drug Delivery Based on Phosphoramidite Chemistry: From Oligonucleotides to Precision Polymers

Yang,

Cui,

Guo

et al. 2024

Biomacromolecules

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Over decades of development, while phosphoramidite chemistry has been known as the leading method in commercial synthesis of oligonucleotides, it has also revolutionized the fabrication of sequence-defined polymers (SDPs), offering novel functional materials in polymer science and clinical medicine. This review has introduced the evolution of phosphoramidite chemistry, emphasizing its development from the synthesis of oligonucleotides to the creation of universal SDPs, which have unlocked the potential for designing programmable smart biomaterials with applications in diverse areas including data storage, regenerative medicine and drug delivery. The key methodologies, functions, biomedical applications, and future challenges in SDPs, have also been summarized in this review, underscoring the significance of breakthroughs in precisely synthesized materials.

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Section: Functions Of Phosphoramidite Chemistry-based Sdpsmentioning

confidence: 99%