Influence of the secondary structure on the AIE-related emission behavior of an amphiphilic polypeptide containing a hydrophobic fluorescent terminal and hydrophilic pendant groups

Lin, Liyang; Huang, Po-Chiao; Yang, Deng-Jie; Gao, Jhen-Yan; Hong, Jin‐Long

doi:10.1039/c5py01485a

Cited by 15 publications

(13 citation statements)

References 55 publications

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“…This is opposite to the molecular weight-dependent emission observed in most AIE polymers. Consequently, the specific polymer conformation has significant impact on the final photophysical properties, including both emission intensity and wavelength ( Figure 4 A), as also indicated in follow-up studies [ 73 ]. This feature can be used to detect variations in the aggregate structure, for example, as a probe for the detection of bovine serum albumin (BSA) [ 74 ].…”

Section: Single-fluorophore Aie Polymers Prepared By Ring-opening Polymerizationmentioning

confidence: 78%

“…( A ) Structure and conformation-dependent AIE properties of tetraphenylthiophene-conjugated poly(γ-benzyl-L-glutamate). Reproduced with permission from [ 73 ], copyright 2016, Royal Society of Chemistry. ( B ) Structure and polymerization-mediated AIE properties of ICT-based PLA and PCL.…”

Section: Single-fluorophore Aie Polymers Prepared By Ring-opening Polymerizationmentioning

confidence: 99%

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Controlling Molecular Aggregation-Induced Emission by Controlled Polymerization

Bao

2021

Molecules

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In last twenty years, the significant development of AIE materials has been witnessed. A number of small molecules, polymers and composites with AIE activity have been synthesized, with some of these exhibiting great potential in optoelectronics and biomedical applications. Compared to AIE small molecules, macromolecular systems—especially well-defined AIE polymers—have been studied relatively less. Controlled polymerization methods provide the efficient synthesis of well-defined AIE polymers with varied monomers, tunable chain lengths and narrow dispersity. In particular, the preparation of single-fluorophore polymers through AIE molecule-initiated polymerization enables the systematic investigation of the structure–property relationships of AIE polymeric systems. Here, the main polymerization techniques involved in these polymers are summarized and the key parameters that affect their photophysical properties are analyzed. The author endeavored to collect meaningful information from the descriptions of AIE polymer systems in the literature, to find connections by comparing different representative examples, and hopes eventually to provide a set of general guidelines for AIE polymer design, along with personal perspectives on the direction of future research.

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Section: Single-fluorophore Aie Polymers Prepared By Ring-opening Polymerizationmentioning

confidence: 78%

Section: Single-fluorophore Aie Polymers Prepared By Ring-opening Polymerizationmentioning

confidence: 99%

Controlling Molecular Aggregation-Induced Emission by Controlled Polymerization

Bao

2021

Molecules

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“…As shown in Figure B, the characteristic signals of α-helix conformation were clearly observed at pH 5.5, indicating the presence of an α-helix structure. When the environmental pH was increased to 6.5, a negative minimum band near 218 nm associated with β-sheet conformation was interestingly found. As the environmental pH value further increased to 7.4, the characteristic signal at 218 nm was slightly reduced but still clearly observed.…”

Section: Resultsmentioning

confidence: 99%

Impact of Secondary Structure of Polypeptides on Glucose Concentration Sensitivity of Nanocarriers for Insulin Delivery

Yang

et al. 2018

ACS Appl. Bio Mater.

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A reasonably intelligent response to glucose concentration fluctuations is crucial for developing a self-regulated insulin delivery system. Inspired by the relationship between the higher ordered structures of proteins and their versatile functions, the introduction of polypeptides capable of mimicking different secondary structures into the delivery system will be anticipated for adjusting glucose concentration sensitivity. Herein, this work presents the impact of different secondary structural architectures of polypeptide blocks on the stability of glucose-responsive complex nanoparticles (CNPs) in the normal physiological environment and their response to the stimuli of normoglycemic and hyperglycemic conditions in vitro. Results from the conformational investigations of the CNPs carried out using circular dichroism and insulin release under the different stimuli suggested that the stability and glucose sensitivity of the CNPs are closely related to the secondary structure composition of the polypeptide blocks. The CNPs with a dominant α-helix structure exhibit a promising potential to improve normal glycemic control and to reduce the incidences of hyperglycemia and hypoglycemia both in vitro and in vivo.

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“…To prepare PPM, the polypeptide Py-PPLG precursor needed to be synthesized first. By using amino-functionalized Py-NH 2 as the initiator to initiate ROP of the cyclic peptide monomer PLG-NCA, the hydrophobic Py terminal was successfully built into the polypeptide Py-PPLG precursor. The subsequent click reaction − between the alkyne side groups of Py-PPLG and MEO 2 -N 3 introduced the hydrophilic methoxy-bis(ethylene oxide) units into the side chains of PPM.…”

Section: Resultsmentioning

confidence: 99%

Pyrene-Terminated, Amphiphilic Polypeptide and Its Hydrogen-Bonded Interpolymer Complex as Delivery Systems of Doxorubicin

2018

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The intensity ratio between the first (373 nm) and the third (383 nm) vibronic peaks [ I 1 / I 3 , as the pyrene (Py) scale] of fluorescent Py was used to monitor the critical concentration, drug-loading, and -releasing behaviors of a Py-terminated, amphiphilic polypeptide PPM and its hydrogen-bonded interpolymer complex (HIPC) with poly(acrylic acid) (PAA). Primarily, an amphiphilic PPM with a hydrophobic Py terminal and hydrophilic methoxy-bis(ethylene oxide) pendant groups was synthesized through multiple preparative steps, and the resultant PPM was thoroughly mixed with PAA through a preferable hydrogen bond (H bond) interaction to form HIPC. The emission study suggested that the I 1 / I 3 ratio and the quantum yield (Φ F ) are effective in determining the critical concentrations of the aqueous PPM and PPM/PAA solutions. Moreover, the I 1 / I 3 ratio and Φ F were found to be convenient measures for determining the amounts of doxorubicin drugs loaded by and released from the aqueous PPM and PPM/PAA solutions.

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Influence of the secondary structure on the AIE-related emission behavior of an amphiphilic polypeptide containing a hydrophobic fluorescent terminal and hydrophilic pendant groups

Abstract: AIE-related emission of polypeptide containing an AIE-active terminal is correlated with secondary structures (α-helix, β-sheet and random coil) of the peptide chains.

Cited by 15 publications

References 55 publications

Controlling Molecular Aggregation-Induced Emission by Controlled Polymerization

Controlling Molecular Aggregation-Induced Emission by Controlled Polymerization

Impact of Secondary Structure of Polypeptides on Glucose Concentration Sensitivity of Nanocarriers for Insulin Delivery

Pyrene-Terminated, Amphiphilic Polypeptide and Its Hydrogen-Bonded Interpolymer Complex as Delivery Systems of Doxorubicin

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