Influence of the preparation method on the physicochemical properties of indomethacin and methyl-β-cyclodextrin complexes

Rudrangi, Shashi Ravi Suman; Bhomia, Ruchir; Trivedi, Vivek; Vine, George J.; Mitchell, John C.; Alexander, Bruce D.; Wicks, Stephen R.

doi:10.1016/j.ijpharm.2015.01.010

Cited by 49 publications

(43 citation statements)

References 44 publications

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“…, respectively (Rudrangi et al, 2015a), while the binding affinity, Van der Waals energy and docking score for inclusion of olanzapine in Me-β-CD were -24.13 kcal mol -1 , -21.57 kcal mol -1 and -3.09 kcal mol -1 , respectively (Rudrangi et al, 2015b).…”

Section: Introductionmentioning

confidence: 98%

“…The ability to increase the water solubility of a drug is thus very important to enhancing its therapeutic efficacy. Several strategies to improve the water solubility and dissolution rate of poorly soluble drugs have been reported (Rudrangi et al, 2011;Bontha et al, 2012;Weerapol et al, 2015;Kaialy and Al Shafiee, 2015;Aroso et al, 2016;Jiang et al, 2016), among which is the inclusion complexation with cyclodextrins (Bandi et al, 2004;Cirri et al, 2005;Vega et al, 2013;Rudrangi et al, 2015a;Rudrangi et al, 2015b).…”

Section: Introductionmentioning

confidence: 99%

“…Rudrangi et al (2015a) reported an AN-subtype phase solubility diagram with a stability constant of K1:1 = 167 M -1 for the indomethacin-Me-β-CD complexes while Rudrangi et al (2015b) reported an AL-subtype phase solubility diagram with a stability constant of K1:1 = 304 M -1 for the olanzapine-Me-β-CD complexes.…”

Section: Introductionmentioning

confidence: 99%

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Solid-state flurbiprofen and methyl-β-cyclodextrin inclusion complexes prepared using a single-step, organic solvent-free supercritical fluid process

Rudrangi

Kaialy

Ghori

et al. 2016

European Journal of Pharmaceutics and Biopharmaceutics

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Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Solid-state flurbiprofen and methyl-β-cyclodextrin inclusion complexes prepared using a single-step, organic solvent-free supercritical fluid process

Rudrangi

Kaialy

Ghori

et al. 2016

European Journal of Pharmaceutics and Biopharmaceutics

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“…However, the treated sample showed XRD peak at 2θ equal to 25.20º. The sharp peaks on the diffractograms of the control and treated samples confirm the crystalline nature of 3-CNB [24]. Moreover, a single sharp peak observed in the treated sample as compared to multiple peaks in the control.…”

Section: Xrd Studymentioning

confidence: 57%

Characterization of Biofield Energy Treated 3-Chloronitrobenzene: Physical, Thermal, and Spectroscopic Studies

Trivedi¹,

Branton²

2015

Int J Waste Resour

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“…10a) corresponds to those of the γ-crystalline form. 32,33) The peak corresponding to the melting temperature of IM was not observed in the DSC thermograms of the tablets containing IM (A20IM, A20H40IM, B20H40IM, and C20H40IM) (Figs. 9h-k).…”

Section: Physical-mechanical Properties Of Mucoadhesive Tabletsmentioning

confidence: 99%

Development of Polyethylene Glycol and Hard Fat-Based Mucoadhesive Tablets Containing Various Types of Polyvinyl Alcohols as Mucoadhesive Polymers for Buccal Application

Ikeuchi-Takahashi

Kobayashi

Onishi

2017

Biological & Pharmaceutical Bulletin

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Topical drug application has the advantage of avoiding systemic side effects. We attempted to develop a long-acting matrix-type tablet containing indomethacin (IM) with low physical stimulus and potent mucoadhesive force to treat pain caused by oral aphtha. A mixture of polyethylene glycol (PEG) and hard fat was used as the tablet base. Ethylcellulose was added to the base in an attempt to control drug release. Tablets with PEG as a base were also prepared for comparison. Polyvinyl alcohols (PVAs) with various degrees of saponification were added to increase the mucoadhesive force. From the optical microscopic observations, formulations using PEG and hard fat exhibit PEG/hard fat dispersions caused by the stabilizing effects of PVA. Although the tablets using PEG and hard fat showed sufficient adhesiveness and sustained drug release, those using PEG as the base did not. Drug release was controlled by the amount of hard fat and the saponification degree of PVA. The drug release rate was most increased in a tablet containing PVA with an intermediate degree of saponification, PEG and hard fat. From differential scanning calorimetry and powder X-ray diffraction, IM was considered to exist in the molecular phase. From the results of buccal administration of tablets to rats, highest tissue concentrations were observed in the tablet containing PVA with the intermediate degree of saponification using PEG and hard fat, and the plasma concentrations were sufficiently low in comparison.

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Influence of the preparation method on the physicochemical properties of indomethacin and methyl-β-cyclodextrin complexes

Cited by 49 publications

References 44 publications

Solid-state flurbiprofen and methyl-β-cyclodextrin inclusion complexes prepared using a single-step, organic solvent-free supercritical fluid process

Solid-state flurbiprofen and methyl-β-cyclodextrin inclusion complexes prepared using a single-step, organic solvent-free supercritical fluid process

Characterization of Biofield Energy Treated 3-Chloronitrobenzene: Physical, Thermal, and Spectroscopic Studies

Development of Polyethylene Glycol and Hard Fat-Based Mucoadhesive Tablets Containing Various Types of Polyvinyl Alcohols as Mucoadhesive Polymers for Buccal Application

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