Influence of the nutritional status in the clinical and therapeutical evolution in adults and elderly with American Tegumentary Leishmaniasis

Oliveira, Amanda Gleyce Lima de; Brito, Patrícia Dias de; Schubach, Armando; Oliveira, Raquel Vasconcellos Carvalhaes de; Saheki, Maurício Naoto; Lyra, Marcelo Rosandiski; Salgueiro, Mariza M; Terceiro, B.F.; Pimentel, Maria Inês Fernandes; Vasconcellos, E.C.; Valete‐Rosalino, Cláudia Maria

doi:10.1016/j.actatropica.2013.06.005

Cited by 22 publications

(24 citation statements)

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“…Regarding general nutritional status in leishmaniasis, a low BMI (<18.5 kg/m 2 ) was found in 10% and hypoalbuminemia (<35 g/L) in 12% of the patients (19). In our patient group only one patient (of 29) has such a low BMI and three patients had a BMI below 20 kg/m 2 .…”

Section: Discussionmentioning

confidence: 99%

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Nutritional status in patients with cutaneous leishmaniasis and a study of the effects of zinc supplementation together with antimony treatment

Guzman-Rivero

Rojas

Verduguez-Orellana

et al. 2014

Food & Nutrition Research

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BackgroundThe role of micronutrient status for the incidence and clinical course of cutaneous leishmaniasis is not much studied. Still zinc supplementation in leishmaniasis has shown some effect on the clinical recovery, but the evidence in humans is limited.ObjectiveTo compare biochemical nutritional status in cutaneous leishmaniasis patients with that in controls and to study the effects of zinc supplementation for 60 days.DesignTwenty-nine patients with cutaneous leishmaniasis were treated with antimony for 20 days. Fourteen of them got 45 mg zinc daily and 15 of them got placebo. Biomarkers of nutritional and inflammatory status and changes in size and characteristics of skin lesions were measured.ResultsThe level of transferrin receptor was higher in patients than in controls but otherwise no differences in nutritional status were found between patients and controls. No significant effects of zinc supplementation on the clinical recovery were observed as assessed by lesion area reduction and characteristics or on biochemical parameters.ConclusionsIt is concluded that nutritional status was essentially unaffected in cutaneous leishmaniasis and that oral zinc supplementation administered together with intramuscular injection of antimony had no additional clinical benefit.

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Section: Discussionmentioning

confidence: 99%

“…In another study, children with visceral leishmaniasis were found to have a lower BMI and plasma albumin than the other groups studied (20). The loss of weight may be attributable in cases of American tegumentary leishmaniasis to difficulties to eat (19) and in visceral leishmaniasis to the cachexia caused by the infection (20). …”

Section: Discussionmentioning

confidence: 99%

Nutritional status in patients with cutaneous leishmaniasis and a study of the effects of zinc supplementation together with antimony treatment

Guzman-Rivero

Rojas

Verduguez-Orellana

et al. 2014

Food & Nutrition Research

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show abstract

“…There were associations between nutritional impairment status and age, mucosal leishmaniasis, events affecting food intake and lesion healing [10]. During treatment, the dogs experienced weight loss of up to 21% of their body weight.…”

Section: Characterisation and Monitoring Of The Study Groupmentioning

confidence: 96%

“…However, human treatment with furazolidone at a dose of 8 mg/kg/day for 10 days was not successful [14]. Most likely, the action of furazolidone is enhanced by the immunostimulatory activity of domperidone [8], since curing leishmaniasis depends on the immune status of the animal [10]. However, no lesions decreased in size during the administration of domperidone.…”

Section: Treatmentmentioning

confidence: 96%

“…Among the eight treated animals, only one did not experience effective epithelialisation of the mucosal lesion possibly due to the dog's advanced age of >12 years. Since the course of clinical leishmaniasis manifestations depends on the immunological status of the animal, the age of the animal may be an important factor for treatment failure; old animals present with immune response impairment [10]. Still, there was mucosal lesion regression in the >12-year-old dog, and three animals required more than one cycle (31 days) of treatment for lesion healing.…”

Section: Treatmentmentioning

confidence: 98%

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