Influence of the Mixtures of Vegetable Oil and Vitamin E over the Microstructure and Rheology of Organogels

Martinez, Renata Miliani; Filho, Pedro Leonidas Oseliero; Gerbelli, Bárbara B.; Magalhães, Wagner Vidal; Velasco, Maria Valéria Robles; Lannes, Suzana Caetano da Silva; Oliveira, Cristiano L. P.; Rosado, Catarina; Baby, André Rolim

doi:10.3390/gels8010036

Cited by 4 publications

(4 citation statements)

References 50 publications

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“…The obtained data are shown in Figure 1C (black-filled circles), and the obtained results are comparable to those previously reported for ordered mesoporous silica. 42–44 It is interesting to note that both curves, with and without peptide, are very similar.…”

Section: Resultsmentioning

confidence: 82%

“…The obtained data are shown in Figure 1C (black-filled circles), and the obtained results are comparable to those previously reported for ordered mesoporous silica. [42][43][44] It is interesting to note that both curves, with and without peptide, are very similar. To describe their structure and eventual differences, we proceeded with the data analysis using the model fully detailed by Losito et al 2021a.…”

Section: Sba-15 Is a Suitable Mesoporous Materials For Anchorage Ac2-26mentioning

confidence: 79%

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Development of Ac2-26 Mesoporous Microparticle System as a Potential Therapeutic Agent for Inflammatory Bowel Diseases

Broering,

Oseliero Filho,

Borges

et al. 2024

IJN

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Inflammatory bowel diseases (IBDs) disrupt the intestinal epithelium, leading to severe chronic inflammation. Current therapies cause adverse effects and are expensive, invasive, and ineffective for most patients. Annexin A1 (AnxA1) is a pivotal endogenous anti-inflammatory and tissue repair protein in IBD. Nanostructured compounds loading AnxA1 or its active N-terminal mimetic peptides improve IBD symptomatology. Methods: To further explore their potential as a therapeutic candidate, the AnxA1 N-terminal mimetic peptide Ac2-26 was incorporated into SBA-15 ordered mesoporous silica and covered with EL30D-55 to deliver it by oral treatment into the inflamed gut. Results:The systems SBA-Ac2-26 developed measurements revealed self-assembled rod-shaped particles, likely on the external surface of SBA-15, and 88% of peptide incorporation. SBA-15 carried the peptide Ac2-26 into cultured Raw 264.7 macrophages and Caco-2 epithelial cells. Moreover, oral administration of Eudragit-SBA-15-Ac2-26 (200 μg; once a day; for 4 days) reduced colitis clinical symptoms, inflammation, and improved epithelium recovery in mice under dextran-sodium sulfate-induced colitis. Discussion: The absorption of SBA-15 in gut epithelial cells is typically low; however, the permeable inflamed barrier can enable microparticles to cross, being phagocyted by macrophages. These findings suggest that Ac2-26 is successfully delivered and binds to its receptors in both epithelial and immune cells, aligning with the clinical results. Conclusion: Our findings demonstrate a simple and cost-effective approach to delivering Ac2-26 orally into the inflamed gut, highlighting its potential as non-invasive IBD therapy.

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Section: Resultsmentioning

confidence: 82%

Section: Sba-15 Is a Suitable Mesoporous Materials For Anchorage Ac2-26mentioning

confidence: 79%

Development of Ac2-26 Mesoporous Microparticle System as a Potential Therapeutic Agent for Inflammatory Bowel Diseases

Broering,

Oseliero Filho,

Borges

et al. 2024

IJN

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“…This can isolate the bioactive substance from degradation agents such as oxygen, moisture, and light, reducing its exposure to these factors and thus creating a physical and diffusion protection barrier. This structure is also favored by the polar minority components and unsaponifiable compounds of the unrefined Amazonian oils [ 12 , 60 ], opening the doors to an important area of research, mainly driven by the possible use of these functional organogels as photo protectors of compounds that function as key bioactive substances (Vitamin A, Vitamin E and antioxidant compounds). Also, they could be a possible vehicle to transport pharmaceutical or dermo-cosmetic active ingredients, using the controlled release mechanism, which is based on the gel’s ability to regulate the diffusion of the active substance (bioactive) from its three-dimensional matrix into the surrounding environment.…”

Section: Discussionmentioning

confidence: 99%

Novel Organogels from Mauritia flexuosa L.f and Caryodendron orinocense Karst.: A Topical Alternative

Narvaez,

Carrillo,

Cardona-Jaramillo

et al. 2023

Pharmaceutics

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Organogels have importance for topical applications because they can be used to deliver drugs in a controlled and prolonged fashion. These are materials consisting of a three-dimensional network of organic molecules dispersed in a solvent. Recent studies have demonstrated that the solvent could be replaced by oils from non-conventional biologic sources. There is a diversity of not-explored species in the Amazon that are promising sources of vegetable oils with a promising composition. This study developed an organogel with buriti (Mauritia flexuosa L.f) and cacay (Caryodendron orinocense Karst.) oils, using cetostearyl alcohol as an organogelator due to its compatibility, stability, security, affordability, and it is readily available. The oils were characterized, and the organogels were synthesized by studying their crystal evolution and oil-binding capacity. The microstructure was evaluated with polarized light microscopy, fractal dimension, FTIR spectroscopy, XRD, and thermal and rheological analyses. It was found that the critical gelation concentration was higher for cacay oil as it possessed a higher amount of polyunsaturated triacylglycerols. The crystals of the buriti organogel had a smaller lamellar shape, a greater surface area, and physical and thermal stability; although, it presented a slower crystal evolution due to the low number of minor compounds and a greater number of saturated triacylglycerols. The polar fraction of the organogelators as well as triacylglycerol and minor polar compounds are important in forming crystallization nuclei. The study showed that Amazonian oils in crystallization processes form microstructures with differentiating physicochemical properties.

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“…In bigels containing aqueous Quercus resinosa polyphenol extracts, an increase in polyphenol concentration increased the consistency index of the bigel [ 30 ]. Similarly, the addition of vitamin E had a sigmoidal, dose-dependent positive impact on the gel strength and phase transition temperature of a 12-hydroxystearic acid/candelilla wax organogel [ 31 ].…”

Section: Bigels: Definition Preparation Methods and Characterizationmentioning

confidence: 99%

Bigels as Delivery Systems: Potential Uses and Applicability in Food

Francavilla

Corradini

Joye

2023

Gels

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Bigels have been mainly applied in the pharmaceutical sector for the controlled release of drugs or therapeutics. However, these systems, with their intricate structures, hold great promise for wider application in food products. Besides their classical role as carrier and target delivery vehicles for molecules of interest, bigels may also be valuable tools for building complex food structures. In the context of reducing or even eliminating undesirable (but often highly functional) food components, current strategies often critically affect food structure and palatability. The production of solid fat systems that are trans-fat-free and have high levels of unsaturated fatty acids is one of the challenges the food industry currently faces. According to recent studies, bigels can be successfully used as ingredients for total or partial solid fat replacement in complex food matrices. This review aims to critically assess current research on bigels in food and pharmaceutical applications, discuss the role of bigel composition and production parameters on the characteristics of bigels and further expand the use of bigels as solid fat replacers and functional food ingredients. The hydrogel:oleogel ratio, selected gelators, inclusion of surfactants and encapsulation of molecules of interest, and process parameters (e.g., temperature, shear rate) during bigel production play a crucial role in the bigel’s rheological and textural properties, microstructure, release characteristics, biocompatibility, and stability. Besides exploring the role of these parameters in bigel production, future research directions for bigels in a food context are explored.

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Influence of the Mixtures of Vegetable Oil and Vitamin E over the Microstructure and Rheology of Organogels

Cited by 4 publications

References 50 publications

Development of Ac2-26 Mesoporous Microparticle System as a Potential Therapeutic Agent for Inflammatory Bowel Diseases

Development of Ac2-26 Mesoporous Microparticle System as a Potential Therapeutic Agent for Inflammatory Bowel Diseases

Novel Organogels from Mauritia flexuosa L.f and Caryodendron orinocense Karst.: A Topical Alternative

Bigels as Delivery Systems: Potential Uses and Applicability in Food

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