Influence of the menstrual cycle on skin‐prick test reactions to histamine, morphine and allergen

Kalogeromitros, D.; Κατσαρού, Αλεξάνδρα; Armenaka, M; Rigopoulos, Dimitrios; Zapanti, M.; I, Stratigos

doi:10.1111/j.1365-2222.1995.tb01078.x

Cited by 74 publications

(43 citation statements)

References 22 publications

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“…Ultrastructural and histochemical examinations show squamous metaplasia of the nasal mucosa in these patients [5,12]. Skin test reactivity in the menstrual cycle shows that the wheal-flare reactions are significantly increased in the mid-cycle when oestrogen levels reach their peak [13], which accords with the nasal hyperreactivity found in this study. One can speculate why oestrogen results in an increased sensitivity to histamine; a downregulation of cortisol receptors in nasal mucosa caused by high serum levels of oestrogen?…”

Section: Discussionsupporting

confidence: 80%

Nasal Mucosal Swelling and Reactivity during a Menstrual Cycle

Haeggström¹,

Østberg

Stjerna³

et al. 1999

ORL

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Introduction: Nasal stuffness is a great problem for many women in the later part of pregnancy. Objective: This study was performed to evaluate whether oestrogen causes nasal congestion and/or a hyperreactive reaction of the nasal mucosa. Material and Methods: Ten healthy fertile women were examined during menstruation. Nasal mucosal congestion was studied with rhinostereometry and acoustic rhinometry. The nasal mucosa was challenged with 3 doses of histamine solution to study nasal reactivity. Measurements were made 3 times during menstruation. To find the exact time of ovulation, when oestrogen reaches its peak value, intravaginal ultrasound tests were done and blood samples taken, to determine the oestrogen and progesterone levels. Results: The nasal mucosa became hyperreactive to histamine in connection with ovulation, when the blood level of oestrogen reached its peak. This does not occur during the menstrual or the luteal phase. No significant alteration was found in the baseline position during the menstruation. Conclusion: There is a connection between high oestrogen level and nasal mucosal reactivity.

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Section: Discussionsupporting

confidence: 80%

Nasal Mucosal Swelling and Reactivity during a Menstrual Cycle

Haeggström¹,

Østberg

Stjerna³

et al. 1999

ORL

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“…Kalogeromitros et al [20] observed that environmental and metabolic factors such as menstrual cycle could affect test reactivity [20]. Consistent with findings reported elsewhere [21], a pilot study performed by our group showed that measurement of wheal size is reproducible, with a low coefficient of variation at histamine concentrations of 10 mg/mL and 100 mg/mL during follow-up in a control group (data not shown).…”

Section: Discussionsupporting

confidence: 79%

Prediction of the Efficacy of Antihistamines in Chronic Spontaneous Urticaria Based on Initial Suppression of the Histamine- Induced Wheal

Sánchez¹,

Zakzuk²,

Cardona

2016

J Investig Allergol Clin Immunol

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Background: Antihistamines are the first line of treatment for chronic spontaneous urticaria. However, there is no effective method to predict whether an antihistamine will have a beneficial clinical effect or not. Objective: To assess whether the change in histamine-induced wheal and flare measurements 24 hours after administration of antihistamine can predict the efficacy of treatment. Methods: We performed a multicenter, triple-blind, randomized study. Patients received a daily oral dose of cetirizine, fexofenadine, bilastine, desloratadine, or ebastine over 8 weeks. After 4 weeks, a higher dose of antihistamine was administered to patients who did not experience a clinical response. A histamine skin prick test was carried out at baseline and 24 hours after the first dose of antihistamine. Disease severity (Urticaria Activity Score [UAS]), response to the histamine skin prick test, and impact on the patient's quality of life (Dermatology Life Quality Index [DLQI]) were determined every 2 weeks. Results: The study population comprised 150 patients (30 per group) and 30 controls. Twenty-four hours after administration of antihistamine, inhibition of the histamine wheal by >75% was significantly associated with better UAS and DLQI scores. The safety and efficacy of the 5 antihistamines were similar. After updosing, rates of disease control (DLQI score <5) increased from 58.7% to 76.7%. Conclusions: Measurement of the histamine-induced wheal can predict which patients will have a strong clinical response to antihistamines but has limited utility for identifying nonresponders. The clinical significance of these data could be relevant in the search for new urticaria treatment regimens.

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“…However, several studies have suggested that female sex hormones influence asthma (41). Atopy, measured by skin-prick test, changes during the menstrual cycle (42). When estrogen levels are high, wheal and flare responses increase (42)(43)(44).…”

Section: Discussionmentioning

confidence: 99%

“…Atopy, measured by skin-prick test, changes during the menstrual cycle (42). When estrogen levels are high, wheal and flare responses increase (42)(43)(44). The proliferation of peripheral blood monocytes to pokeweed mitogen is increased in the presence of estrogen, whereas testosterone inhibits this response (45,46).…”

Section: Discussionmentioning

confidence: 99%

Sex Differences in Factors Associated with Childhood- and Adolescent-Onset Wheeze

Mandhane

Greene

Cowan

et al. 2005

Am J Respir Crit Care Med

127

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Rationale: Factors predicting the development of wheeze may differ between sexes and between childhood and adolescence. Methods: A New Zealand birth cohort of 1,037 children was followed to age 26. For this analysis, those reporting recurrent wheezing at two or more assessments were classified as "wheezers." We examined risk factors for development of wheeze before age 10 (childhood) and subsequently (adolescent-onset) for males and for females separately using Cox regression modeling. Results: Males more often developed childhood wheeze (p ϭ 0.002) and females adolescentonset wheeze (p Ͻ 0.001). Maternal atopy (asthma or hay fever) was a risk factor for childhood wheeze in both sexes (hazard ratio [HR], 1.48, p Ͻ 0.05 for males; HR, 2.37, p Ͻ 0.001 for females). Paternal atopy also influenced childhood wheeze, significantly for males (HR, 1.72; p ϭ 0.01), and similarly but not significantly for females (HR, 1.70; p ϭ 0.08). For adolescent-onset wheeze, neither maternal (HR, 1.41; p ϭ 0.19) nor paternal history (HR, 0.73; p ϭ 0.42) was a risk factor in males, but maternal history (HR, 2.08; p Ͻ 0.01) was a significant risk factor for females. When both age ranges were combined, providing greater power for analysis, paternal history was a stronger risk factor for wheeze in females (HR, 1.62; p ϭ 0.02) than in males (HR, 1.35; p ϭ 0.12). Conclusion: The influence of parental atopy on the development for wheeze differs between males and females and between childhood-and adolescent-onset wheeze.

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Influence of the menstrual cycle on skin‐prick test reactions to histamine, morphine and allergen

Cited by 74 publications

References 22 publications

Nasal Mucosal Swelling and Reactivity during a Menstrual Cycle

Nasal Mucosal Swelling and Reactivity during a Menstrual Cycle

Prediction of the Efficacy of Antihistamines in Chronic Spontaneous Urticaria Based on Initial Suppression of the Histamine- Induced Wheal

Sex Differences in Factors Associated with Childhood- and Adolescent-Onset Wheeze

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