Influence of the MCT1-T1470A polymorphism (rs1049434) on blood lactate accumulation during different circuit weight trainings in men and women

Cupeiro, Rocío; González‐Lamuño, Domingo; Amigo, Teresa; Peinado, Ana B.; Ruiz, Jonatan R.; Ortega, Francisco B.; Benito, Pedro J.

doi:10.1016/j.jsams.2012.03.009

Cited by 43 publications

(56 citation statements)

References 15 publications

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“…During dynamic exercises, approximately 80% of muscle lactate is transported across the sarcolemma by the MCT family of transporters [10]. More recently, a polymorphism in the MCT1 gene has been suggested to play an important role in muscle lactate transport [12] and accumulation [13], as described above, suggesting that MCT1 TT genotype increases blood lactate clearance via the transport of lactate from exercised to non-exercised muscle cells, in which lactate can be oxidized. Thus, our findings suggest that the TT genotype could increase the lactate influx to non-exercised muscles, delaying ventilatory compensation for the first increase in blood lactate concentration and carbon dioxide pressure.…”

Section: Discussionmentioning

confidence: 90%

“…It has been suggested that the MCT1 gene is able to influence lactate kinetics during exercise [12,13]. However, to the best of our knowledge, no study has investigated the impact of MCT1 gene polymorphism on the ventilatory thresholds traditionally associated with aerobic fitness.…”

Section: Discussionmentioning

confidence: 99%

“…VT is related to the first increase in blood H+ ions and lactate levels during incremental exercise [6], which are mainly transported from muscle by the MCT family of transporters [10]. Utilizing a circuit-training mode, Cupeiro et al [13] observed less lactate accumulation in individuals with the TT genotype. Thus, it is possible that the TT genotype might delay the blood lactate accumulation.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, a more recent study demonstrated that the MCT1 T allele is associated with less lactate accumulation after strength exercises [13]. Collectively, these results suggest that the MCT1 gene polymorphism could influence the lactate kinetics through both lactate influx to nonactive or efflux out of the active [13], and gas exchange during exercise, known as important parameters to fitness status evaluation [1,14]. In regard of sports performance, the MCT1 A1470T results are quite inconclusive and still scarce, with only three studies analyzing the MCT1 genotypes frequencies among athletes.…”

Section: Introductionmentioning

confidence: 99%

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Association between Ventilatory Thresholds Related to Aerobic Fitness and MCT1 A1470T Polymorphism

Pasqua¹,

Damasceno²,

Bueno³

2016

Sports Nutr Ther

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The purpose of this study was to verify the association between MCT1 polymorphism with physiological parameters related to aerobic fitness. A hundred fifty healthy male volunteers performed a maximal incremental running test to determine the speeds corresponding to Ventilatory Threshold (VT) and Respiratory Compensation Point (RCP). Participants were genotyped and divided in terciles based on the analyzed variables. Genotype frequencies were compared through chi-square test between lower (LT) and higher terciles (HT), with the lowest or highest values of each analyzed variable. MCT1 TT genotype was overrepresented in HT only for VT and showed a significantly higher odds ratio of belong to HT for VT compared only to AA (5.1). These results suggest that TT individuals could attain the VT and RCP at higher speeds, being able to sustain higher running speeds in lower exercise intensity domains. In other words, it is possible that individuals carrying the MCT1 TT genotype might run at higher speeds with lower fatigue signals, mimicking an inner aerobic fitness adaptation.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association between Ventilatory Thresholds Related to Aerobic Fitness and MCT1 A1470T Polymorphism

Pasqua¹,

Damasceno²,

Bueno³

2016

Sports Nutr Ther

View full text Add to dashboard Cite

show abstract

“…Both lactate influx into or efflux out of the muscle is increased when MCT1 is increased [9]. The AA genotype carriers have higher blood lactate levels compared to the TT and TA genotypes during different exercise protocols [12].…”

Section: Genetic Profilementioning

confidence: 97%

Practical uses of genetic profile assessment in athletic training – an illustrative case study

Meckel

Ben‐Zaken

Nemet

et al. 2014

AKUT

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Recent studies suggested that several potential genes may explain athletic success. However, while genetic assessment will probably become part of future talent identifi cation, at present, genetic testing predictive value is poor, mainly because athletic success depends on a combination of genetic, physiological, behavioral and environmental factors (including coaching, medical, nutritional, psychological, equipment, facilities and administrative aspects). However, one should consider genetic testing not only for talent identifi cation or sport event selection, but also for possible assistance in the training process itself. In the present case study we show an example of potential practical use of genetic profi le assessment for improving the athletic training process. We deliberately chose a case study of a national-level athlete to show that genetic aid should not be limited to top world-class athletes.

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Monocarboxylate Transporters: Therapeutic Targets and Prognostic Factors in Disease

Jones

Morris

2016

Clin Pharma and Therapeutics

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Solute carrier (SLC) transporters represent 52 families of membrane transport proteins that function in endogenous compound homeostasis and xenobiotic disposition, and have been exploited in drug delivery and therapeutic targeting strategies. In particular, the SLC16 family that encodes for the 14 isoforms of the monocarboxylate transporter (MCT) family plays a significant role in the absorption, tissue distribution, and clearance of both endogenous and exogenous compounds. MCTs are required for the transport of essential cell nutrients and for cellular metabolic and pH regulation. Recent publications have indicated their novel roles in disease, and thus their potential as biomarkers and new therapeutic targets in disease are under investigation. More research into MCT isoform function, specificity, expression, and regulation will allow researchers to exploit the potential utility of MCTs in the clinic as therapeutic targets and prognostic factors of disease.

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Influence of the MCT1-T1470A polymorphism (rs1049434) on blood lactate accumulation during different circuit weight trainings in men and women

Cited by 43 publications

References 15 publications

Association between Ventilatory Thresholds Related to Aerobic Fitness and MCT1 A1470T Polymorphism

Association between Ventilatory Thresholds Related to Aerobic Fitness and MCT1 A1470T Polymorphism

Practical uses of genetic profile assessment in athletic training – an illustrative case study

Monocarboxylate Transporters: Therapeutic Targets and Prognostic Factors in Disease

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