Influence of the Major Histocompatability Complex on Disease Resistance and Productivity

Bacon, Larry D.

doi:10.3382/ps.0660802

Cited by 192 publications

(109 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our results from lines XP02 and XP21 confirm the resistance of the B2i haplotype (XP21) and B 2 haplotype (XP02) against multiple MD viral strains (Gavora et al, 1986;Bacon 1987 In the determination of the PHA swelling index, possible differences in wing web thickness of the right and left wing or the variation in the response to PBS were not considered as it was shown that they are negligible (Van der Zijpp, 1983).…”

Section: Introductionsupporting

confidence: 51%

Correlations of genetic resistance of chickens to Marek's disease viruses with vaccination protection and in vivo response to phytohemaglutinin

Gavora¹,

Spencer²,

Okada³

et al. 1990

Genet. Sel. Evol.

View full text Add to dashboard Cite

show abstract

Section: Introductionsupporting

confidence: 51%

Correlations of genetic resistance of chickens to Marek's disease viruses with vaccination protection and in vivo response to phytohemaglutinin

Gavora¹,

Spencer²,

Okada³

et al. 1990

Genet. Sel. Evol.

View full text Add to dashboard Cite

show abstract

“…The major histocompatibility complex (MHC) B alleles have been found to play a major role in resistance to AL viraemia and tumour development (Bacon, 1987). A link between MHC genotype and the risk of becoming a virus shredder has also been reported (Yoo and Sheldon, 1992).…”

Section: Avian Infectious Bronchitismentioning

confidence: 99%

An assessment of opportunities to dissect host genetic variation in resistance to infectious diseases in livestock

Davies

Genini

Bishop

et al. 2009

Animal

View full text Add to dashboard Cite

This paper reviews the evidence for host genetic variation in resistance to infectious diseases for a wide variety of diseases of economic importance in poultry, cattle, pig, sheep and Atlantic salmon. Further, it develops a method of ranking each disease in terms of its overall impact, and combines this ranking with published evidence for host genetic variation and information on the current state of genomic tools in each host species. The outcome is an overall ranking of the amenability of each disease to genomic studies that dissect host genetic variation in resistance. Six disease-based assessment criteria were defined: industry concern, economic impact, public concern, threat to food safety or zoonotic potential, impact on animal welfare and threat to international trade barriers. For each category, a subjective score was assigned to each disease according to the relative strength of evidence, impact, concern or threat posed by that particular disease, and the scores were summed across categories. Evidence for host genetic variation in resistance was determined from available published data, including breed comparison, heritability studies, quantitative trait loci (QTL) studies, evidence of candidate genes with significant effects, data on pathogen sequence and on host gene expression analyses. In total, 16 poultry diseases, 13 cattle diseases, nine pig diseases, 11 sheep diseases and three Atlantic salmon diseases were assessed. The top-ranking diseases or pathogens, i.e. those most amenable to studies dissecting host genetic variation, were Salmonella in poultry, bovine mastitis, Marek’s disease and coccidiosis, both in poultry. The top-ranking diseases or pathogens in pigs, sheep and Atlantic salmon wereEscherichia coli, mastitis and infectious pancreatic necrosis, respectively. These rankings summarise the current state of knowledge for each disease and broadly, although not entirely, reflect current international research efforts. They will alter as more information becomes available and as genome tools become more sophisticated for each species. It is suggested that this approach could be used to rank diseases from other perspectives as well, e.g. in terms of disease control strategies.

show abstract

“…This strain of chickens was chosen for its high susceptibility to MD (Longenecker & Mosmann, 1981;Bacon, 1987).…”

Section: Chickensmentioning

confidence: 99%

Effect of Cryptosporidium baileyi in specific pathogen free chickens vaccinated (CVI988/Rispens) and challenged with HPRS-16 strain of Marek's

et al. 2000

View full text Add to dashboard Cite

This study was performed to examine the effect of Marek's disease virus (MDV) serotype 1 vaccine (CVI988/Rispens) on the pathogenicity of Cryptosporidium baileyi, and to determine whether C. baileyi infection could prevent the development of vaccinal Marek's disease (MD) immunity in specific pathogen free (SPF) chickens. Sixty-eight SPF homozygous B13 White Leghorn chickens were divided into seven groups. C. baileyi was orally administered at 5 days of age (day 4) in chickens infected with Rispens vaccine at day 0 or at day 8 and challenged with HPRS-16 strain of oncogenic MDV at day 15. Relevant control groups were constituted. The chickens were kept in isolators until the end of the experiment at day 62. The parameters evaluated were clinical signs, kinetics of oocyst shedding, mortality, macroscopic and microscopic lesions, cryptosporidia location in various organs and serum anti-C. baileyi antibodies at days 42 and 62. Our results show that C. baileyi, which is considered to be non-pathogenic when inoculated orally, may become highly pathogenic. It induced severe mortality and developed in organs other than classical target sites when chickens were vaccinated with Rispens vaccine and challenged with the HPRS-16 strain of MDV. However, parasite infection does not prevent the induction of vaccinal immunity for MD. Our results also show that vaccination of B13 chickens at hatching induces higher protection against challenge with HPRS-16 MDV at day 15 than vaccination at day 8.

show abstract

Influence of the Major Histocompatability Complex on Disease Resistance and Productivity

Cited by 192 publications

References 35 publications

Correlations of genetic resistance of chickens to Marek's disease viruses with vaccination protection and in vivo response to phytohemaglutinin

Correlations of genetic resistance of chickens to Marek's disease viruses with vaccination protection and in vivo response to phytohemaglutinin

An assessment of opportunities to dissect host genetic variation in resistance to infectious diseases in livestock

Effect of Cryptosporidium baileyi in specific pathogen free chickens vaccinated (CVI988/Rispens) and challenged with HPRS-16 strain of Marek's

Contact Info

Product

Resources

About