Influence of the Linoleic Acid Content of the Diet on Tumor Growth in Transplantable Rat Tumor Models

Abstract

Diets high (17.7 cal%) and low (3.3 cal%) in linoleic acid were given to groups of Brown Norway female rats before and after inoculation of syngeneic tumor models with different characteristics, with regard to tumor spread, malignancy, immunogenicity, growth rate, rat strain, and histopathological features. Despite the differences in characteristics, in most tumor models, tumor growth was identical in both experimental groups. However, in 2 tumor models, an adrenal cortical carcinoma and a myeloid leukemia, differences in growth were noted. In rats given the diet low in linoleic acid, growth of the cortical carcinoma was significantly increased, whereas the opposite effect was seen in rats with myeloid leukemia.

Diets Rich in Fish Oil Cannot Control Tumor Cell Metastasis

“…Although there are differ ences in tumor malignancy between tumor BN472 and BN 175 (BN 175 is the more ag gressive one; tumor growth rate is higher [14]), one may conclude that there is a corre lation between tumor malignancy and tumor TXA2 synthesis; however, the fact that the fibroblast cell line could also produce con siderable amounts of TXA2 militates against such a connection.…”

“…The tumor used in this study, originally classified as a malignant mammary adenocarcinoma (BN472), is a transplantable tumor routinely used in our studies on tumor growth and metastases [14). When im planted subcutaneously, the tumor metastasizes spon taneously from the primary site to the regional lymph nodes and lungs.…”

Adjuvant intraoperative photodynamic therapy diminishes the rate of local recurrence in a rat mammary tumour model

“…Mammary tumour BN472 was chosen for this particular study, as it grows invasively from the inoculation site, metastasises to regional lymph nodes and lungs, and mostly recurs at the operation site despite complete macroscopic excision (Kort et al, 1986a). The tumour is a moderately differentiated adenocarcinoma, originating from a BN female rat in one of our studies on spontaneous tumour incidence (Kort et al, 1986b …”