Influence of the Herbal Preparation "Licorice Oil" on the State of Hematopoiesis in Rats Under Ionizing Irradiation

Изтлеуов, М К; Teleuov, Murat; Iztleuov, Yerbolat; Сапарбаев, С. С.; Yelubayeva, Alma; Yemzharova, Gulmira; Sambayeva, Sanimgul; Turganbayeva, Aigul; Umirzakova, Zhanat

doi:10.13005/bpj/2189

Cited by 3 publications

(1 citation statement)

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“…Results of this study revealed that, pre-treated by licorice extract can mitigate all the adverse effects of cisplatin on hematological parameters. (Iztleuov et al, 2021) also obtained similar results that rats were intoxicated by Gamma irradiation the emptying of the bone marrow, which is defined by a decrease in the level of cellular elements in the blood and bone marrow cellularity by 41%, 50%, and 25%, led to a noticeable and lasting shift in the peripheral blood picture. In comparison to the control group, 42 percent, 35 percent, and 46 percent improved.…”

Section: Discussionsupporting

confidence: 59%

Hematological Findings Associated with the Use of Licorice and Silymarin in Cisplatin-Treated Rats

Hamed

Abdulla²,

Kilany³

2022

Suez Canal Veterinary Medical Journal. SCVMJ

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The purpose of this study was to assess the effect of licorice and silymarin supplementations on some hematological parameters in cisplatin treated albino rats. A total of 72 normal male albino rats' weight 150 -200 gm. The rats were allowed for acclimation for one week at the animal shelter. The rats were divided randomly into six groups, each with 12 rats. Group (1): normal control group and fed with commercial balanced diet. Group (2): licorice extract orally treated group for 6 weeks at a rate of 2 gm/kg body weight. Group (3): silymarin orally treated group at a rate of 100mg/kg every day for six weeks. Group (4): served as hepatotoxic group treated by injection of cisplatin (CP) intraperitoneally in a dose of 1.5 mg/kg body weight every two weeks for three weeks starting from the 4 th week of the experiment. Group (5): received licorice extract orally treated group at a rate of 2 gm/kg body weight for 6 weeks. and injected cisplatin intraperitoneally in a dose of 1.5 g/kg body weight repeated twice a week for 6 weeks starting from the 4 th week of the experiment. Group (6): received silymarin orally treated group at a rate of 100mg/kg daily for 6 weeks. and injected cisplatin intraperitoneally in a dose of 1.5 mg/kg body weight every two weeks for six weeks starting from the 4 th week of the experiment. The purpose of this study was to investigate the effects of oral administration of licorice and silymarin extracts for 6 weeks on some hematological parameters in cisplatin treated albino rats. These effects were explored by measuring hematological parameters. Group injected with cisplatin revealed decrease RBCs count, Hb concentration, and values of PCV, MCV, MCH and MCHC. When compared with normal control group, there is microcytic hypochromic anemia associated with leukocytosis, neutrophilia, eosinophilia, and lymphopenia, also thrombocytopenia is recorded. All these parameters were improved in treated (licorice and silymarin) CP intoxicated groups compared with non-treated CP intoxicated group.

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Section: Discussionsupporting

confidence: 59%

Hematological Findings Associated with the Use of Licorice and Silymarin in Cisplatin-Treated Rats

Hamed

Abdulla²,

Kilany³

2022

Suez Canal Veterinary Medical Journal. SCVMJ

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Effect of Burdock Root Oil on Oxidative Stress Induced by Isolated and Combined Use of Gamma Radiation and Hexavalent Chromium

Iztleuov

Saparbayev

et al. 2022

Biomed. Pharmacol. J.

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They studied the effect of the herbal medicine "Burdock root oil" on oxidative damage to liver, kidney and blood tissues. The experiment was performed on 50 non-linear white male rats weighing 180-220 g, divided into 5 groups. The first group - control; animals of groups II and III were subjected to fractional gamma irradiation for five days (0.6 G/day; dose rate 1 Gr/min (60Co)). The total dose was 3 Gr. Animals of the fourth and fifth groups were exposed to a combination of gradiation (as in groups I and III) and potassium dichromate (Cr+6). Potassium dichromate was administered intraperitoneally daily at a dose of 2.8 mg/kg of body weight (0.1LD50) for 5 days (0.5LD50). Rats of groups 3 and 5 received Burdock root oil at a dose of 2.5 ml/kg of body weight intragastrically for 14 days prior to the experimental exposure. Fractional exposure, combined exposure g-radiation, gamma radiation and Cr+6 led to an increase in malondialdehyde and diene conjugates in blood plasma, liver and kidney tissues. Under g-irradiation, the activity of superoxide dismutase enzymes (SOD) and catalase (CAT) in red blood cells compensation increased significantly against the background of a decrease in the level of SH-groups in blood plasma. In liver and kidney tissues, all studied enzymes and reduced glutathione (GSH) levels decreased. Under the conditions of combined exposure g-radiation and potassium dichromate - all the studied indicators of antioxidant protection decreased. The introduction of Burdock root oil before isolated and combined exposure provided significant antioxidant protection in the studied tissues. Conclusion: it can be assumed, that the "Burdock root oil" it is a potential drug that can be used as a radiation protector, in conditions of combined influence of a physical and chemical agent-a detoxifier. In our opinion, the antioxidant potential of the herbal medicine justifies the continuation of further research in clinical practice.

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Effect of Boric Acid on Oxidative Damage in Immunocompetent Organs under Conditions of Potassium Bichromate and Gamma Radiation Exposure

Iztleuov,

Temirova

et al. 2023

Biomed. Pharmacol. J.

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The immune system supports antigenic homeostasis in the body and regulates the processes of proliferation and differentiation of cellular components in hemo- and immunopoiesis. Chromium compounds and ionizing radiation lead to the formation of highly reactive free radicals. Sublethal dose of gamma-irradiation is characterized by a 56% decrease in thymus cellularity and a 22% decrease in lymph nodes against the background of a 44% increase in the number of lymphoid cells in the spleen. Under the combined effect of hexavalent chromium and gamma-radiation, a decrease in the number of lymphoid cells is observed. In thymus the cellularity decreases by 70%, in spleen - by 40%, in lymph nodes - by 42% in comparison with control data. Under the influence of boric acid the number of lymphoid cells in thymus significantly increases by 47%, in lymph nodes - by 14% (p<0.05) compared to the data of irradiated animals. Boric acid administration weakens the development of oxidative stress, lipid peroxidation decreases, and the activity of antioxidant defense enzymes in immunocompetent cells is increased.

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Influence of the Herbal Preparation "Licorice Oil" on the State of Hematopoiesis in Rats Under Ionizing Irradiation

Cited by 3 publications

References 0 publications

Hematological Findings Associated with the Use of Licorice and Silymarin in Cisplatin-Treated Rats

Hematological Findings Associated with the Use of Licorice and Silymarin in Cisplatin-Treated Rats

Effect of Burdock Root Oil on Oxidative Stress Induced by Isolated and Combined Use of Gamma Radiation and Hexavalent Chromium

Effect of Boric Acid on Oxidative Damage in Immunocompetent Organs under Conditions of Potassium Bichromate and Gamma Radiation Exposure

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