The structural and magnetic properties of three magnetron sputtered multilayers at the 2nd maximum of antiferromagnetic coupling were studied using 59 Co NMR spectroscopy: [Cο(20 A)/Cu(20 A)]20, [Cο(20 Å)/ Ru(18 Å)]20 and a heterostructure, in which non-magnetic spacers alternated between Cu and Ru. Co/Cu interfaces were found to be relatively sharp, extended over 3 monolayers, while the Co/Ru interfaces extend over 6 monolayers due to the good miscibility of Co and Ru. The NMR restoring field in the heterostructure is found to be the average of the restoring fields in both reference samples.PACS numbers: 76.60. Lz, 75.70.Ρa, 75.70.Cn, 75.20.En Co/Ru multilayers display one of the strongest antiferromagnetic (AF) coupling ever reported in a multilayer system [1]. In spite of that, the giant magnetoresistance (GMR) effect is very low in these materials, which has been attributed to a considerable interdiffusion of interfaces [2], or to a small difference between the spin-polarized density of states at the Fermi level [3]. With the aim to improve the magnetotransport properties -GMR higher with respect to Co/Ru multilayers and magnetoresistive hysteresis smaller than that observed in Co/Cu multilayers at 2nd maximum of antiferromagnetic coupling (2nd AFM) -we have prepared a heterostructure with the following layer sequence: [Cο(20 Å)/Ru(19 Α)/Cox(20 Α)/Cu(21 R)] 10, grown on 100Å Ru buffer. The GMR effect that we have measured in this heterostructure is 5 times higher that that observed in the corresponding Co/Ru multilayer. Its absolute value (1.5%) is, however, still too low to be considered for practical applications and about 10 times lower than GMR exhibited by Co/Cu multilayers. Compared to Co/Cu multilayers at the 2nd AFM, the heterostructure displays reduced magnetoresistive hysteresis. Also, the saturation field is reduced about twice with respect to the Co/Ru multilayer. In order to elucidate mechanisms responsible for the observed magneto-transport properties' we have carried out a detailed structural study in (551)