Influence of the geometry around the manganese ion on the peroxidase and catalase activities of Mn(III)–Schiff base complexes

Vázquez-Fernández, M. Ángeles; Bermejo, Manuel R.; Fernández-García, M. Isabel; González-Riopedre, Gustavo; Rodriguez‐Douton, Maria Jesus; Maneiro, Marcelino

doi:10.1016/j.jinorgbio.2011.09.002

Cited by 43 publications

(58 citation statements)

References 40 publications

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“…As a result of these supramolecular interactions, the Mn⋅ ⋅ ⋅ Mn distances of about 4.96Å are short for monomeric compounds. These types of systems have been reported in literature [15,16] as -acuo dimers. …”

Section: Crystal Structure Ofmentioning

confidence: 84%

“…Peroxidase activity for complexes 1-3 was tested according to the literature procedure [15,16] by study of the oxidation of 2,2 -azinobis-(3-ethylbenzothiazoline)-6-sulfonic acid (ABTS) with H 2 O 2 at ca. pH 6.8 in the presence of the complexes.…”

Section: Peroxidase Probesmentioning

confidence: 99%

“…During our search for new metal catalysts containing salen-type ligands, we have observed a better catalytic behaviour when the substrate molecule can be easily coordinated by the complex and this is favoured when the catalyst has either a vacancy in the coordination sphere or a labile ligand [14][15][16][17]. To achieve this, a careful design of the environment around the metal ion is necessary.…”

Section: Introductionmentioning

confidence: 99%

“…Peroxidases catalyse oxidation of a broad range of substrates by hydrogen hydroxide, so they may be successfully used for different industrial processes since peroxidases are capable of degrading aromatic rings in lignin, dyes, and polycyclic aromatic hydrocarbons [15,16,20,21]. In this sense, dyes are regarded as one of the most important contaminants to be removed from the industrial effluents, and peroxidases arise as a way to treat these pollutants.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, Characterization, and Catalytic Studies of Mn(III)-Schiff Base-Dicyanamide Complexes: Checking the Rhombicity Effect in Peroxidase Studies

Bermejo

Carballido

Fernández-García

et al. 2017

Journal of Chemistry

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The condensation of 3-methoxy-2-hydroxybenzaldehyde and the diamines 1,2-diphenylendiamine, 1,2-diamine-2-methylpropane and 1,3-propanediamine yielded the dianionic tetradentate Schiff base ligands N,N -bis(2-hydroxy-4-methoxybenzylidene3 ) respectively. The organic compounds H 2 L 1 and H 2 L 2 have been characterized by elemental analysis, IR, 1 H and 13 C NMR spectroscopies and mass spectrometry electrospray (ES). The crystal structure of H 2 L 2 in solid state, solved by X-ray crystallography, is highly conditioned in the solid state by two N-H•••N intramolecular interactions. The synthesis of three new manganese(III) complexes 1-3, incorporating these ligands, H 2 L 1 -H 2 L 3 , and dicyanamide (DCA), is reported. The complexes 1-3 have been physicochemically characterized by elemental analysis, IR and paramagnetic 1 H NMR spectroscopy, ESI mass spectrometry, magnetic moment at room temperature and conductivity measurements. Complex 1 has been crystallographically characterized. The X-ray structure shows the self-assembly of the Mn(III)-Schiff base-DCA complex through -aquo bridges between neighbouring axial water molecules and also by -stacking interactions, establishing a dimeric structure. The manganese complexes were also tested as peroxidase mimics for the H 2 O 2 -mediated reaction with the water-soluble trap ABTS, showing complexes 1-2 relevant peroxidase activity in contrast with 3. The rhombicity around the metal ion can explain this catalytic behaviour.

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Section: Crystal Structure Ofmentioning

confidence: 84%

Section: Peroxidase Probesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Synthesis, Characterization, and Catalytic Studies of Mn(III)-Schiff Base-Dicyanamide Complexes: Checking the Rhombicity Effect in Peroxidase Studies

Bermejo

Carballido

Fernández-García

et al. 2017

Journal of Chemistry

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“…Schiff base ligands with nitrogen and oxygen donor atoms may provide a chemical environment which can mimic the coordination spheres of manganese in biological systems better than any other ligand type. A whole host of manganese Schiff base complexes have been reported in this context during the last few decades [19][20][21][22][23][24][25][26][27]. Among these, there is a sizeable number of complexes of the salpn…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Crystal Structure of [MnIII(5-Br-salpn)(D

S¹,

Basheer²,

Shyla³

2013

International Journal of Inorganic Chemistry

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e title compound was synthesized by the reaction between a manganese(II) carboxylate and the tetradentate Schiff base ligand, 5-Br-salpnH 2 [N,N ′ -bis(5-Br-salicylidene)-1,3-diaminopropane] produced in situ. e complex crystallizes in the P2 1 /c space group with unit cell dimensions 12 (10), 12 (10), 2 (3), , 1 2 1 (10), and . e manganese(III) ion is in a distorted octahedral environment with longer axial bonds.

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Synthesis, structural elucidation, and density functional theory investigation of new mononuclear Fe(III), Ni(II), and Cu(II) mixed‐ligand complexes: Biological and catalase mimicking activity exploration

Abdou

Abdel‐Mawgoud

2022

Applied Organom Chemis

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The present paper deals with synthesis new mononuclear 1:1:1 metal:ligand:co‐ligand complexes, FeLG, NiLG, and CuLG, where L = 1‐{(E)‐[(4‐methylphenyl)imino]methyl}‐2‐naphthol and G = Glycine. The synthesized complexes were characterized based on elemental analysis, Fourier transform infrared spectroscopy (FT‐IR), ultraviolet–visible (UV–vis), mass spectra, molar conductance, magnetic susceptibility, and thermal analysis (TGA) in addition to stoichiometry determination via molar ratio method. The isolated metal complexes showed interesting geometry variation as tetrahedral for CuLG and octahedral for both FeLG and NiLG. The molecular structures of the titled compounds were optimized theoretically using density functional theory (DFT) approach, and the quantum chemical descriptors were calculated. The disk diffusion method was used to investigate the growth inhibition of the titled compounds aganist selected pathogenic bacterial and fungal strains. The metal complexes exhibited higher enhancement as antimicrobial candidates with lower minimum inhibitory concentration (MIC) than the free ligands, and in some cases, the complexes were closed to the standard species. Molecular docking investigation was carried out to ascertain the inhibitory action of the studied compounds against 1HNJ protein, the target enzyme for the antimicrobial agents. The results indicated that the FeLG has the highest binding affinity in comparison with other compounds. Thus, these molecules could be promising antimicrobial candidates. Furthermore, catalase mimicking activity of the complexes has been investigated. The data revealed that CuLG complex catalyzes the decomposition of hydrogen peroxide most effectively. Finally, the quantum chemical parameters of the titled complexes and other different compounds were correlated with their practical biological activity data in a trial to build a SAR model.

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Influence of the geometry around the manganese ion on the peroxidase and catalase activities of Mn(III)–Schiff base complexes

Cited by 43 publications

References 40 publications

Synthesis, Characterization, and Catalytic Studies of Mn(III)-Schiff Base-Dicyanamide Complexes: Checking the Rhombicity Effect in Peroxidase Studies

Synthesis, Characterization, and Catalytic Studies of Mn(III)-Schiff Base-Dicyanamide Complexes: Checking the Rhombicity Effect in Peroxidase Studies

Synthesis and Crystal Structure of [MnIII(5-Br-salpn)(D

Synthesis, structural elucidation, and density functional theory investigation of new mononuclear Fe(III), Ni(II), and Cu(II) mixed‐ligand complexes: Biological and catalase mimicking activity exploration

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