Influence of the Flavonoid, Quercetin on Antioxidant Status, Lipid Peroxidation and Histopathological Changes in Hyperammonemic Rats

Kanimozhi, S; Bhavani, P.; Subramanian, Perumal

doi:10.1007/s12291-016-0603-8

Cited by 17 publications

(8 citation statements)

References 26 publications

(22 reference statements)

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“…Under abnormal conditions such as hyperammonemia in rats, quercetin was found to protect against oxidative stress and exert anti-inflammatory activity [86]. During induced oxidative stress in rats, rutin was found to act as a strong antioxidant protecting against oxidative effects [87]. Moreover, in another in vitro study, it was demonstrated that kaempferol has moderate oxygen radical absorption capacity and strong radical-scavenging activity [80].…”

Section: Antioxidant Activity Of Dietary Flavonoids and Cancer Incmentioning

confidence: 99%

Dietary Flavonoids as Cancer Chemopreventive Agents: An Updated Review of Human Studies

2019

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Over the past few years, interest in health research has increased, making improved health a global goal for 2030. The purpose of such research is to ensure healthy lives and promote wellbeing across individuals of all ages. It has been shown that nutrition plays a key role in the prevention of some chronic diseases such as obesity, cardiovascular disease, diabetes, and cancer. One of the aspects that characterises a healthy diet is a high intake of vegetables and fruits, as both are flavonoid-rich foods. Flavonoids are one of the main subclasses of dietary polyphenols and possess strong antioxidant activity and anti-carcinogenic properties. Moreover, some population-based studies have described a relationship between cancer risk and dietary flavonoid intake. In this context, the goal of this review was to provide an updated evaluation of the association between the risk of different types of cancers and dietary flavonoid intake. We analysed all relevant epidemiological studies from January 2008 to March 2019 using the PUBMED and Web of Science databases. In summary, this review concludes that dietary flavonoid intake is associated with a reduced risk of different types of cancer, such as gastric, breast, prostate, and colorectal cancers.

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Section: Antioxidant Activity Of Dietary Flavonoids and Cancer Incmentioning

confidence: 99%

Dietary Flavonoids as Cancer Chemopreventive Agents: An Updated Review of Human Studies

2019

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“…Quercetin is a much studied flavonoid compound with various bioactive properties. Studies have shown that it possesses antioxidant, anticarcinogenic, antiviral, antithrombotic and anti-inflammatory potentials respectively ( Moosavi et al., 2016 ; Kanimozhi et al., 2017 ). Gallic acid also possesses strong antioxidant potential ( Khan et al., 2020 ; Ezzati et al., 2020 ; Abarikwu et al., 2017 ), while the antioxidant potential of rutin has also been investigated by others ( Manzoni et al., 2020 ; Liu et al., 2020 ; Sharma et al., 2020 ; Halvorsen et al., 2006 ).…”

Section: Discussionmentioning

confidence: 99%

“…Dysregulated liver function biomarkers were also normalized by the administration of ELE-PM especially the most effective dose of 600 mg/kg. Studies have shown that quercetin and gallic acid have the potentials to normalize dysregulated liver function markers and reduce MDA level in vivo in various experimental disease conditions ( Moosavi et al., 2016 ; Goudarzi et al., 2017 ; Kanimozhi et al., 2017 ). Perhaps, these bioactive compounds earlier identified in ELE-PM through the HPLC studies may be responsible for this striking antioxidant potential in addition to the healing effect on the cellular membrane of the hepatocytes.…”

Section: Discussionmentioning

confidence: 99%

Ethanol leaf extract of Psychotria microphylla rich in quercetin restores heavy metal induced redox imbalance in rats

Orji

Awoke

Harbor

et al. 2020

Heliyon

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Psychotria microphylla is a plant found in Africa and many parts of the world where the leaves are locally used in folk medicine for the treatment of toxicity related liver diseases. We investigated the antioxidant potentials of ethanol leaf extract of Psychotria microphylla (ELE-PM) in restoring hepatic redox dysregulations in rats exposed to heavy metals. HPLC was used in quantifying the bioactive compounds in ELE-PM. DPPH (1,1-diphenyl-2 picrylhydrazyl), FRAP (Ferric reducing antioxidant power) and NO (Nitric Oxide) assays were used for in vitro studies. The in vivo studies involved 30 rats randomly divided into 5 groups ( n = 6). Group 1 received normal saline (2 mg/kg), group 2, 3, 4 and 5 received a combined solution of Pb(NO 3 ) 2 (11.25 mg/kg) and HgCl 2 (0.4 mg/kg) respectively. After 7 days of heavy metal exposure, groups 3, 4 and 5 received a daily bolus administration of 200, 400 and 600 mg/kg body weight of EE-PM respectively through oral intubation for 28 days. HPLC quantification revealed a high amount of quercetin (27.43 ± 0.04 mg/100g), lower amounts of gallic acid (7.60 ± 0.06 mg/100g) and rutin (0.38 ± 0.009 mg/100g). Additionally, ELE-PM demonstrated strong inhibitory potentials against free radical scavenging activity generated in vitro . More interestingly, administration of ELE-PM significantly ameliorated hepatic redox dysregulations elicited by the exposure of the rats to heavy metals in a dose dependent pattern. ELE-PM is highly rich in flavonoid compound quercetin and perhaps this may be responsible for the strong antioxidant potentials exhibited in this investigation.

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“…These compounds must be hydrolyzed by enzymes from the colon microflora before being absorbed. For example, most glycoside forms resist acid hydrolysis in rat stomachs, although absorption in the gastric portion occurs for some flavonoids, such as quercetin, but not their glycosides [ 33 ]. In general, plasma concentrations vary according to the nature of the polyphenols and the food source [ 34 , 35 ].…”

Section: Bioavailability and Dietary Polyphenol Intakementioning

confidence: 99%

Polyphenols from Root, Tubercles and Grains Cropped in Brazil: Chemical and Nutritional Characterization and Their Effects on Human Health and Diseases

et al. 2017

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Throughout evolution, plants have developed the ability to produce secondary phenolic metabolites, which are important for their interactions with the environment, reproductive strategies and defense mechanisms. These (poly)phenolic compounds are a heterogeneous group of natural antioxidants found in vegetables, cereals and leguminous that exert beneficial and protective actions on human health, playing roles such as enzymatic reaction inhibitors and cofactors, toxic chemicals scavengers and biochemical reaction substrates, increasing the absorption of essential nutrients and selectively inhibiting deleterious intestinal bacteria. Polyphenols present in some commodity grains, such as soy and cocoa beans, as well as in other vegetables considered security foods for developing countries, including cassava, taro and beetroot, all of them cropped in Brazil, have been identified and quantified in order to point out their bioavailability and the adequate dietary intake to promote health. The effects of the flavonoid and non-flavonoid compounds present in these vegetables, their metabolism and their effects on preventing chronic and degenerative disorders like cancers, diabetes, osteoporosis, cardiovascular and neurological diseases are herein discussed based on recent epidemiological studies.

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Influence of the Flavonoid, Quercetin on Antioxidant Status, Lipid Peroxidation and Histopathological Changes in Hyperammonemic Rats

Cited by 17 publications

References 26 publications

Dietary Flavonoids as Cancer Chemopreventive Agents: An Updated Review of Human Studies

Dietary Flavonoids as Cancer Chemopreventive Agents: An Updated Review of Human Studies

Ethanol leaf extract of Psychotria microphylla rich in quercetin restores heavy metal induced redox imbalance in rats

Polyphenols from Root, Tubercles and Grains Cropped in Brazil: Chemical and Nutritional Characterization and Their Effects on Human Health and Diseases

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