Influence of the eye globe design on biomechanical analysis

Issarti, Ikram; Koppen, Carina; Rozema, Jos J

doi:10.1016/j.compbiomed.2021.104612

Cited by 15 publications

(15 citation statements)

References 27 publications

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“…Regarding the optic nerve, typically, the complete meningeal layers have not been included, and in some cases, only the pia mater has been added [ 31 , 33 , 36 ]. In this respect, in a prior FE study we found that ONH strains decreased considerably when meninges were progressively integrated [ 35 ], which suggests that anatomical variability and oversimplification may result in inaccuracy [ 41 ].…”

Section: Introductionmentioning

confidence: 99%

The impact of horizontal eye movements versus intraocular pressure on optic nerve head biomechanics: A tridimensional finite element analysis study

Sarmiento

Montaño²,

Rodríguez³

2023

Heliyon

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Section: Introductionmentioning

confidence: 99%

The impact of horizontal eye movements versus intraocular pressure on optic nerve head biomechanics: A tridimensional finite element analysis study

Sarmiento

Montaño²,

Rodríguez³

2023

Heliyon

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“…Studies have shown that eyeball design can affect the results of biomechanical analysis. Issarti et al [ 49 ] assessed the mechanical contribution of intraocular structures to corneal deformation by establishing the whole eyeball FE mode. The corneal mechanical deformation under different mechanical conditions revealed that the lens, iris, and muscle are also the main factors that should be considered.…”

Section: In Vitro Biomechanical Study Methods Of Eye Tissuementioning

confidence: 99%

Biomechanical analysis of ocular diseases and its in vitro study methods

Zhao

Yan

et al. 2022

BioMed Eng OnLine

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Ocular diseases are closely related to the physiological changes in the eye sphere and its contents. Using biomechanical methods to explore the relationship between the structure and function of ocular tissue is beneficial to reveal the pathological processes. Studying the pathogenesis of various ocular diseases will be helpful for the diagnosis and treatment of ocular diseases. We provide a critical review of recent biomechanical analysis of ocular diseases including glaucoma, high myopia, and diabetes. And try to summarize the research about the biomechanical changes in ocular tissues (e.g., optic nerve head, sclera, cornea, etc.) associated with those diseases. The methods of ocular biomechanics research in vitro in recent years are also reviewed, including the measurement of biomechanics by ophthalmic equipment, finite element modeling, and biomechanical analysis methods. And the preparation and application of microfluidic eye chips that emerged in recent years were summarized. It provides new inspiration and opportunity for the pathogenesis of eye diseases and personalized and precise treatment.

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“…Hence, the adoption of the fluid-structure interaction (FSI) analysis, where the structural domain is combined with the fluid domain, has become of great interest. Ariza-Gracia et al ( Ariza-Gracia et al, 2018 ), Maklad et al ( Maklad et al, 2020b ) and Issarti et al ( Issarti et al, 2021 ) demonstrated that the best numerical approach to reproduce the NCT is the FSI simulation. Ariza-Gracia et al ( Ariza-Gracia et al, 2018 ) considered a 2D model, which limits the study to an isotropic cornea, Maklad et al ( Maklad et al, 2020b ) and Issarti et al ( Issarti et al, 2021 ) used a limited fluid domain.…”

Section: Introductionmentioning

confidence: 99%

“…Ariza-Gracia et al ( Ariza-Gracia et al, 2018 ), Maklad et al ( Maklad et al, 2020b ) and Issarti et al ( Issarti et al, 2021 ) demonstrated that the best numerical approach to reproduce the NCT is the FSI simulation. Ariza-Gracia et al ( Ariza-Gracia et al, 2018 ) considered a 2D model, which limits the study to an isotropic cornea, Maklad et al ( Maklad et al, 2020b ) and Issarti et al ( Issarti et al, 2021 ) used a limited fluid domain. Even though the cornea contains multi-scale structures with distinct patterns of fiber organization ( Blackburn et al, 2019 ), to the best of authors knowledge, current FSI solutions ( Ariza-Gracia et al, 2018 ) ( Maklad et al, 2020b ) ( Issarti et al, 2021 ) do not account for the anisotropy of the cornea in the simulation.…”

Section: Introductionmentioning

confidence: 99%

“…Ariza-Gracia et al ( Ariza-Gracia et al, 2018 ) considered a 2D model, which limits the study to an isotropic cornea, Maklad et al ( Maklad et al, 2020b ) and Issarti et al ( Issarti et al, 2021 ) used a limited fluid domain. Even though the cornea contains multi-scale structures with distinct patterns of fiber organization ( Blackburn et al, 2019 ), to the best of authors knowledge, current FSI solutions ( Ariza-Gracia et al, 2018 ) ( Maklad et al, 2020b ) ( Issarti et al, 2021 ) do not account for the anisotropy of the cornea in the simulation. This work presents a high-fidelity fluid-structure finite-element model of an idealized 3D eye to virtually reproduce the NCT.…”

Section: Introductionmentioning

confidence: 99%

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A detailed methodology to model the Non Contact Tonometry: a Fluid Structure Interaction study

Redaelli

Grasa

Calvo

et al. 2022

Front. Bioeng. Biotechnol.

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Understanding the corneal mechanical properties has great importance in the study of corneal pathologies and the prediction of refractive surgery outcomes. Non-Contact Tonometry (NCT) is a non-invasive diagnostic tool intended to characterize the corneal tissue response in vivo by applying a defined air-pulse. The biomarkers inferred from this test can only be considered as indicators of the global biomechanical behaviour rather than the intrinsic biomechanical properties of the corneal tissue. A possibility to isolate the mechanical response of the corneal tissue is the use of an inverse finite element method, which is based on accurate and reliable modelling. Since a detailed methodology is still missing in the literature, this paper aims to construct a high-fidelity finite-element model of an idealized 3D eye for in silico NCT. A fluid-structure interaction (FSI) simulation is developed to virtually apply a defined air-pulse to a 3D idealized eye model comprising cornea, limbus, sclera, lens and humors. Then, a sensitivity analysis is performed to examine the influence of the intraocular pressure (IOP) and the structural material parameters on three biomarkers associated with corneal deformation. The analysis reveals the requirements for the in silico study linked to the correct reproduction of three main aspects: the air pressure over the cornea, the biomechanical properties of the tissues, and the IOP. The adoption of an FSI simulation is crucial to capture the correct air pressure profile over the cornea as a consequence of the air-jet. Regarding the parts of the eye, an anisotropic material should be used for the cornea. An important component is the sclera: the stiffer the sclera, the lower the corneal deformation due to the air-puff. Finally, the fluid-like behavior of the humors should be considered in order to account for the correct variation of the IOP during the test which will, otherwise, remain constant. The development of a strong FSI tool amenable to model coupled structures and fluids provides the basis to find the biomechanical properties of the corneal tissue in vivo.

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Influence of the eye globe design on biomechanical analysis

Cited by 15 publications

References 27 publications

The impact of horizontal eye movements versus intraocular pressure on optic nerve head biomechanics: A tridimensional finite element analysis study

The impact of horizontal eye movements versus intraocular pressure on optic nerve head biomechanics: A tridimensional finite element analysis study

Biomechanical analysis of ocular diseases and its in vitro study methods

A detailed methodology to model the Non Contact Tonometry: a Fluid Structure Interaction study

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