A method of increasing the efficiency of thermoelectric system for providing thermal modes of distributed heat-loaded elements of an on-board information system is considered. It is shown that thermoelectric coolers are most susceptible to thermal effects. In accordance with the reliability model, they are connected in series with heat loaded elements and to a great extent determine their operability. The inclusion of thermoelectric coolers in the feedback loop of a thermal management system places increased demands on the dynamic performance of the coolers. However, dynamics and reliability performance are at odds with each other, requiring compromise approaches to cooler design and control. Studies have been carried out for an uneven temperature field, a typical dissipation power range, and a fixed geometry of thermocouple