Influence of the dopamine D2 receptor (DRD2) genotype on neuroadaptive effects of alcohol and the clinical outcome of alcoholism

Finckh, Ulrich; Rommelspacher, H.; Kühn, Silke; Dufeu, Peter; Otto, G; Heinz, Andreas; Dettling, Michael; Giraldo-Velásquez, Mario; Pelz, Jörg; Gräf, K.-J.; Harms, Helmut; Sander, Thomas; Schmidt, L. G.; Rolfs, Arndt

doi:10.1097/00008571-199708000-00002

Cited by 81 publications

(52 citation statements)

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“…There is evidence that depression and anxiety symptoms in alcohol withdrawal reflect a mixture of various physiological states and traits involving at least partly the dopaminergic system. In two genetic studies by Finckh et al [12] and our own group [13] examining this subject, depression and anxiety scores during detoxification were associated with variants of the dopamine 2 receptor gene (DRD2 exon 8). In our study, the SCL-90-R was used.…”

Section: Discussionmentioning

confidence: 85%

The Use of a Symptom Checklist (SCL-90-R) as an Easy Method to Estimate the Relapse Risk after Alcoholism Detoxification

et al. 2002

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We tested the use of some subscales of the psychiatric symptom checklist SCL-90-R in predicting relapse within a 1-year follow-up period after a combined detoxification- and abstinence-focused day patient psychotherapy program in 20 men and 13 women with alcohol dependence. Scores of the SCL-90-R subscales interpersonal sensitivity (p = 0.008), anxiety (p = 0.022), phobic anxiety (p = 0.019) and Global Severity Index (GSI; p = 0.040) on admission were higher in the subgroup with relapse within the first year after therapy. A decrease in depression (p = 0.004), anxiety (p = 0.006) and GSI (p = 0.006) scores during therapy was associated with a longer abstinence duration (shorter vs. longer than 24 weeks). Therefore we propose to further investigate the capacity of the SCL-90-R to identify subgroups at higher risk for relapse after detoxification and abstinence therapy in patients with alcohol dependence.

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Section: Discussionmentioning

confidence: 85%

The Use of a Symptom Checklist (SCL-90-R) as an Easy Method to Estimate the Relapse Risk after Alcoholism Detoxification

et al. 2002

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“…Most research focuses on the relationship between dopamine genes and specific behavioral or health outcomes, such as smoking, obesity, alcoholism, risky behavior, and sensation seeking (Erblich et al 2005;Guo et al 2007;Finckh et al 1997;Guo et al 2010;Derringer et al 2010). These outcomes are all related to general health (Cherpitel 1999;Manderbacka et al 1999), but less research has addressed the relationship between the genes we study and overall health measures.…”

Section: Methodsmentioning

confidence: 99%

“…All three of these polymorphisms are in the dopamine system, which plays an important role in a variety of behaviors related to general and self-perceived health. For example, variation at DRD2, DRD4, and DAT1 has been associated with smoking (Erblich et al 2005), obesity (Guo et al 2007), alcoholism withdrawal and relapse (Finckh et al 1997), risky behavior (Guo et al 2010) and sensation seeking (Derringer et al 2010). More details about each gene are provided below.…”

Section: Candidate Genesmentioning

confidence: 99%

“…The specific neurotransmitter genes studied here are candidates for experiencing frequency dependent selection because they are associated with behaviors that have implications for reproductive chances, including smoking (Erblich et al 2005), obesity (Guo et al 2007), alcoholism withdrawal and relapse (Finckh et al 1997), risky behavior (Guo et al 2010) and sensation seeking (Derringer et al 2010). In a context where risky behavior is common, for example, an allele associated with risky behavior or sensation seeking could increase the likelihood of accidents or death while providing little benefit, thereby reducing reproductive fitness.…”

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confidence: 99%

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Sibling genes as environment: Sibling dopamine genotypes and adolescent health support frequency dependent selection

Rauscher

Conley

Siegal

2015

Social Science Research

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While research consistently suggests siblings matter for individual outcomes, it remains unclear why. At the same time, studies of genetic effects on health typically correlate genotype with the average level of a particular phenotype, ignoring more complicated genetic dynamics. Using National Longitudinal Study of Adolescent Health data, we investigate whether sibling genotype moderates individual genetic expression. We compare twin variation in health-related absences and self-rated health by genotype at three locations in the dopamine system -DRD2, DRD4, and DAT1 -to test sibship-level cross-person gene-gene interactions. Results suggest effects of allelic variation at these loci are moderated by the meta-genomic environment of the sibship unit.Evidence of frequency dependent selection suggests much genetic research may violate the stable unit treatment value assumption.

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“…183 An A-G polymorphism in the 3′utr of exon 8 of the D2 receptor gene was associated with increased number of suicide attempts in alcoholics. 184 No differences between Swedish suicide attempters of mixed psychiatric diagnoses and controls 185 or between Israeli adolescent suicide attempters and controls 186 was found in the dopamine receptor subtype 4 (DRD4) gene exon III 48 bp repeat polymorphism.…”

Section: Dopaminergic Systemmentioning

confidence: 99%

Stress, Genes and the Biology of Suicidal Behavior

Currier

Mann

2008

Psychiatric Clinics of North America

131

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Suicidal behavior is in part heritable. Studies seeking the responsible candidate genes have examined genes involved in neurotransmitter systems demonstrated to have altered function in suicide and attempted suicide. These neurotransmitter systems include the serotonergic, noradrenergic and dopaminergic systems and the HPA axis. With some exceptions, most notably the serotonin transporter promotor HTTLPR polymorphism, replication of candidate gene association studies findings has proven difficult. This chapter reviews what is known of specific gene effects and geneenvironment interactions that influence risk for suicidal behavior. Effects of childhood stress on development and how that influences adult responses to current stress will be shown to be relevant for mood disorders, aggressive/impulsive traits and suicidal behavior. KeywordsSuicide; Mood Disorders; Genetics; Stress; Serotonin; HPA axis Suicidal Behavior and GeneticsFamily, twin, and adoption studies provide evidence of the heritability of suicide and attempted suicide, in part independent of the familial transmission of major psychiatric disorders (see Brent & Mann for a review 1 ). From twin studies, based on case and register studies, estimates of heritability for suicide range between 21-50%, and 30-55% for a broader phenotype of suicidal behavior (attempts, thoughts, plans) based on general population studies. 2 Identifying the relevant genes and the neurobiological pathways through which they contribute to the etiology of suicidal behavior is important for designing and implementing preventative strategies. The first wave of genetic studies sought to identify genes involved in suicide and/ or attempted suicide by linkage studies or specific single nucleotide polymorphisms (SNPs) in association studies. Emerging approaches aim to investigate functional genomics using microarray technologies to profile expression of thousands of genes simultaneously (see Mirnics et al 3 for a review) or doing a genome wide array for hundreds of thousands of SNPs.Candidate genes for association studies have been generally selected based on evidence from neurobiological studies in suicide. Consequently, the serotonergic system has been most extensively investigated, with other target systems including the dopaminergic and

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Influence of the dopamine D2 receptor (DRD2) genotype on neuroadaptive effects of alcohol and the clinical outcome of alcoholism

Cited by 81 publications

References 0 publications

The Use of a Symptom Checklist (SCL-90-R) as an Easy Method to Estimate the Relapse Risk after Alcoholism Detoxification

The Use of a Symptom Checklist (SCL-90-R) as an Easy Method to Estimate the Relapse Risk after Alcoholism Detoxification

Sibling genes as environment: Sibling dopamine genotypes and adolescent health support frequency dependent selection

Stress, Genes and the Biology of Suicidal Behavior

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