Influence of the degree of methacrylation on hyaluronic acid hydrogels properties

Bencherif, Sidi A.; Srinivasan, Ashok; Horkay, Ferenc; Hollinger, Jeffrey O.; Matyjaszewski, Krzysztof; Washburn, Newell R.

doi:10.1016/j.biomaterials.2007.11.047

Cited by 252 publications

(258 citation statements)

References 21 publications

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“…On the other hand, formation of the A 4 hydrogel with low cross-linking density, showed the highest degree of swelling ranging between 350% and 375% after immersion in normal saline for 72 h compared to other hydrogels that showed 275-300%. In a study, Bencherif et al [19] had also demonstrated that lower the cross-linking density of the hydrogel, higher will be the water absorption capacity. This characteristic of the A 4 hydrogel could be the positive indication for treating fullthickness exuding wounds.…”

Section: Swelling Study Of Hydrogelsmentioning

confidence: 99%

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Synthesis and Characterization of γ-irradiated PVA/PEG/CaCl2 Hydrogel for Wound Dressing

Dutta¹

2012

CHEMISTRY

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The mixtures of polyvinyl alcohol (PVA) and polyethylene glycol (PEG) with calcium chloride (CaCl 2 ) were exposed to gamma-irradiation to synthesize transparent hydrogels for wound dressing. In this system, CaCl 2 was used not only as a gelling material but also as a plasticizer. The presence of CaCl 2 enhances the effects of PEG, this synergistic effects give births a new hydrogel with improved characteristics. The water absorption capacity of the hydrogel was in the range of 350-375% after immersion in normal saline for 72 h. In vitro weight loss experiments were conducted at 37 o C in order to simulate the use of dressing on wounded skin. The enhanced thermal stability of the hydrogel was confirmed by thermogravimetric analysis (TGA). FTIR studies confirmed the cross-linking between PVA and PEG in the hydrogel. Furthermore, the microbe penetration test of the hydrogel was carried out to confirm its impermeability to bacteria. The effect of hydrogel on cell proliferation was also evaluated to ensure that the hydrogel does not release materials which might be deleterious to cell proliferation. The results showed that the hydrogel could be considered as a potential wound-dressing material.

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Section: Swelling Study Of Hydrogelsmentioning

confidence: 99%

“…The equilibrium swelling ratio is inversely related to the extent of cross-linking. The procedure for this experiment is mentioned elsewhere [19].…”

Section: Characterizationmentioning

confidence: 99%

Synthesis and Characterization of γ-irradiated PVA/PEG/CaCl2 Hydrogel for Wound Dressing

Dutta¹

2012

CHEMISTRY

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“…Aiming to substitute sodium atoms in hyaluronic acid sodium salt by methacrylate units the reaction with glycidyl methacrylate was applied according to the method described in [14] and hyaluronic acid glycidyl methacrylate (HAGM) capable of crosslinking has been obtained as a result.…”

Section: Methodsmentioning

confidence: 99%

Extrusion-Based 3D Printing of Photocurable Hydrogels in Presence of Flavin Mononucleotide for Tissue Engineering

Savelyev¹,

Sochilina²,

Akasov³

et al. 2018

Sovrem Tehnol Med

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3D printing became a widely used technique for tissue engineering applications. This additive technology enables easy fabrication of very complicated structures. However, selection and preparation of initial compositions for 3D printing satisfying high biocompatibility and processability requirements still remains challenging. One of the most promising materials for mimicking of the living tissues are hydrogels possessing properties close to native tissues. In this work, the printability of hydrogels based on hyaluronic acid and poly(ethylene glycol) derivatives dissolved in phosphate buffer saline in presence of flavin mononucleotide as an endogenous photosensitizer has been studied. To produce a hydrogel pattern, the extrusion of photocurable composition has been combined with its simultaneous photoinduced crosslinking under laser irradiation at 450 nm. Cytotoxicity of fabricated films and 3D scaffolds has been tested in vitro using human fibroblasts BJ-5ta.Key words: extrusion; 3D printing; photocurable hydrogel; hyaluronic acid. Hоw to cite: Savelyev A.G., Sochilina A.V., Akasov R.A., Mironov A.V., Semchishen V.A., Generalova A.N., Khaydukov E.V., Popov V.K. Extrusion-based 3D printing of photocurable hydrogels in presence of flavin mononucleotide for tissue engineering. Sovremennye tehnologii v medicine 2018; 10(1): 88, https://doi

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“…reactions in solid phase [57]-; "click chemistry" syntheses, which are simple and chemoselective, proceed with fast kinetics in aqueous ambient, under mild conditions, leading to quantitative yields, without appreciable amounts of side products -i.e. the thiol-ene reaction [150], the Dies-Alder cycloaddition [151] and the azide-alkyne cycloaddition [152]; in situ crosslinking of functionalized HA through air oxidation [153]; photocrosslinking of functionalized HA in presence of photosensitizers [154,155].…”

Section: Preprints (Wwwpreprintsorg) | Not Peer-reviewed |mentioning

confidence: 99%

Hyaluronic Acid in the 3rd Millennium

Fallacara¹,

Baldini²,

Manfredini³

et al. 2018

Preprint

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Since its first isolation in 1934, hyaluronic acid (HA) has been studied across a variety of research areas. This unbranched glycosaminoglycan consisting of repeating disaccharide units of N-acetyl-D-glucosamine and D-glucuronic acid is almost ubiquitary in humans and in other vertebrates. HA is involved in many key processes -including cell signaling, wound reparation, tissue regeneration, morphogenesis, matrix organization and pathobiology-, and has unique physico-chemical properties -such as biocompatibility, biodegradability, mucoadhesivity, hygroscopicity and viscoelasticity. For these reasons, exogenous HA has been investigated as drug delivery system and treatment in cancer, ophthalmology, arthrology, pneumology, rhinology, urology, aesthetic medicine and cosmetic. To improve and customize its properties and applications, HA can be subjected to chemical modifications: conjugation and crosslinking. The present review gives an overview regarding HA, describing its history, physico-chemical, structural and hydrodynamic properties, and biology -occurrence, biosynthesis (by hyaluronan synthases), degradation (by hyaluronidases and oxidative stress), roles, mechanisms of action and receptors. Furthermore, both conventional and recently emerging methods developed for the industrial production of HA and its chemical derivatization are presented. Finally, the medical, pharmaceutical and cosmetic applications of HA and its derivatives are reviewed, reporting examples of HA-based products which currently are on the market or are undergoing further investigations.

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Influence of the degree of methacrylation on hyaluronic acid hydrogels properties

Cited by 252 publications

References 21 publications

Synthesis and Characterization of γ-irradiated PVA/PEG/CaCl<SUB>2 </SUB>Hydrogel for Wound Dressing

Synthesis and Characterization of γ-irradiated PVA/PEG/CaCl<SUB>2 </SUB>Hydrogel for Wound Dressing

Extrusion-Based 3D Printing of Photocurable Hydrogels in Presence of Flavin Mononucleotide for Tissue Engineering

Hyaluronic Acid in the 3<sup>rd</sup> Millennium

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