Influence of the Degree of Gastric Mucosal Atrophy on the Serum Lipid Levels Before and After the Eradication of&lt;i&gt; Helicobacter pylori&lt;/i&gt; Infection

Adachi, Kyoichi; Mishiro, Tsuyoshi; Okimoto, Eiko; Kinoshita, Yoshikazu

doi:10.2169/internalmedicine.1074-18

Cited by 7 publications

(8 citation statements)

References 34 publications

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“…Adachi et al . reported that the HDL cholesterol level was significantly lower in the H. pylori ‐positive group than in the H. pylori ‐negative group and lipid metabolism was influenced by the degree of mucosal atrophy present 31 . In children, however, severe gastric mucosal atrophy is rare, as mentioned earlier 32,33 .…”

Section: Discussionmentioning

confidence: 89%

Association between Helicobacter pylori antibody‐positive status and extragastric diseases in Japanese junior high school students

Abe

Kusano

Takano

et al. 2021

Pediatrics International

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Background Helicobacter pylori (H. pylori) infection causes various extragastric diseases. Its transmission route has still not been clarified. However, no large‐scale studies have examined the extragastric diseases caused by H. pylori in adolescents. This study aimed to examine the association of H. pylori infection with anemia, serum cholesterol levels, physique, and birth delivery method (vaginal or cesarean) in a large number of Japanese adolescents. Methods From 2016 to 2018, we screened 2,399 adolescents (aged 13–15 years) in their second and third years of junior high school using an enzyme‐linked immunosorbent assay‐based antibody test. Red blood cells, hemoglobin, hematocrit, total cholesterol, high‐density lipoprotein (HDL) cholesterol, and serum antibody levels were measured. Results Hemoglobin and hematocrit levels were significantly lower in the H. pylori antibody‐positive group than in the H. pylori antibody‐negative group in both sexes (boys: P = 0.0004 and 0.0022; girls: P = 0.0019 and 0.0005, respectively). Total cholesterol and non‐HDL cholesterol levels were significantly higher in the H. pylori‐positive group than in the H. pylori‐negative group among boys (P = 0.0370 and 0.0293 respectively). There was no significant difference in body mass index percentile and birth delivery method between the H. pylori‐positive and H. pylori‐negative groups in both boys and girls. Conclusions Among Japanese junior high school students, H. pylori antibody‐positive status was associated with anemia in both sexes while total cholesterol and non‐HDL cholesterol levels were associated among boys. There was no association between H. pylori antibody status, body mass index percentile, and birth‐delivery method.

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Section: Discussionmentioning

confidence: 89%

Association between Helicobacter pylori antibody‐positive status and extragastric diseases in Japanese junior high school students

Abe

Kusano

Takano

et al. 2021

Pediatrics International

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“…A precise medical history concerning the status of H. pylori infection (negative, positive, post-eradication) was obtained in an interview with the patient conducted by a public health nurse. Serum anti- H. pylori IgG antibody detection was performed using a SphereLight H. pylori antibody J Ⓡ kit (FUJIFILM Wako Pure Chemical Corporation, Osaka) (11-13). The antibody titer was automatically determined using a chemiluminescent enzyme immunoassay (CLEIA), with a value of 4.0 U/mL defined as positive, according to the manufacturer's instructions.…”

Section: Methodsmentioning

confidence: 99%

Prevalence of Autoimmune Gastritis in Individuals Undergoing Medical Checkups in Japan

et al. 2019

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Objective Based on both endoscopic findings and serum auto-antibody levels, we determined the prevalence of autoimmune gastritis (AIG), which has not been previously reported, in individuals who underwent health checkup examinations in Japan. Methods At total of 6,739 subjects (4,288 males, 2,451 females; mean age 52.1 years) underwent an upper gastrointestinal endoscopic examination as part of an annual medical checkup. Those suspected to have AIG based on endoscopic evidence of proximal-predominant gastric mucosal atrophy were further examined for the presence of anti-parietal cells and anti-intrinsic factor antibodies, with a final diagnosis of AIG made in cases found to be positive for either or both of those factors. Results Of the 6,739 examined subjects, 46 were suspected to have AIG based on the endoscopic findings, of whom 33 were finally diagnosed with AIG, for an overall prevalence 0.49% (females 0.65%, males 0.40%). Seven with AIG also had thyroid disease, including Hashimoto's and Basedow disease, while none with AIG showed anemia in blood test findings. The prevalence of AIG was not different regardless of the H. pylori infection status (negative, positive, post-eradicated). Conclusion In individuals who underwent an upper gastrointestinal endoscopic examination as part of an annual checkup in Japan, the prevalence of AIG was 0.49%. We concluded that it is not uncommon for asymptomatic and healthy individuals to have AIG, and propose that additional studies are needed to clarify its prevalence as well as to establish the criteria used for diagnosis.

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“…Table 1 summarizes the effect of H. pylori eradication on the lipid levels in 4 RCTs, 4 cohort studies, three case–control studies, and 13 before–after studies [ 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 ]. The median values for HDL-C, TG, LDL-C, and TC before H. pylori eradication were 52.1 (range: 30.1 to 64.8) mg/dL, 128 (range: 80.2 to 177.0) mg/dL, 122.2 (range: 101.8 to 146.0) mg/dL, and 195.0 (range: 158.0 to 212.1) mg/dL, respectively, in Appendix A : Table A1 , Table A2 , Table A3 and Table A4 .…”

Section: Resultsmentioning

confidence: 99%

“…In addition, inflammation and oxidative stress alter HDL-C-related enzymes; for example, lecithin-cholesterol acyltransferase, cholesterol ester transfer protein, and hepatic lipase levels are reduced while endothelial lipase levels are increased, which can reduce the HDL-C levels [ 54 , 55 ]. Abnormal cholesterol transport is another reason for the reduction in HDL-C levels, a phenomenon seen in H. pylori infection [ 39 , 40 ]. As another etiological mechanism, the microbiome may be involved [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

“…The levels of LDL-C and TC did not change markedly following H. pylori eradication, the reasons for which were unclear. First, interestingly, the degree of gastric mucosal atrophy is indicated to be associated with the LDL-C levels [ 37 , 39 , 68 ]. As advanced atrophy does not clearly change even after H. pylori eradication, this may partially explain the finding of no marked post-eradication changes in the levels of LDL-C or TC.…”

Section: Discussionmentioning

confidence: 99%

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The Effect of Helicobacter pylori Eradication on Lipid Levels: A Meta-Analysis

Watanabe

Hamasaki

Kotani

2021

JCM

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Introduction: Helicobacter pylori (H. pylori) infection is positively associated with cardiovascular diseases, but the involvement of lipids in this association remains unclear. The present study reviewed the changes in circulating lipid levels following H. pylori eradication. Methods: A PubMed database was searched until December 2020 to identify randomized control trials (RCTs) and non-RCTs investigating the effect of H. pylori eradication on the lipid levels in inverse variance-weighted, random-effects meta-analyses. Results: A total of 24 studies (four RCTs and 20 non-RCTs) with 5270 participants were identified. The post-eradication levels were increased for high-density lipoprotein cholesterol (HDL-C; mean difference (MD) 2.28 mg/dL, 95% confidence interval (CI) 1.90 to 2.66) and triglyceride (TG; MD 3.22 mg/dL, 95% CI 1.13 to 5.31) compared with the pre-eradication levels. H. pylori eradication resulted in little to no difference in the low-density lipoprotein-cholesterol levels (MD −2.33 mg/dL, 95% CI −4.92 to 0.26). In the analyses of RCTs only, the findings for elevated HDL-C levels, but not TG, were robust. Conclusions: H. pylori eradication increases the HDL-C levels. Further studies are needed to elucidate the effects of lipid changes following H. pylori eradication on cardiovascular diseases.

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Influence of the Degree of Gastric Mucosal Atrophy on the Serum Lipid Levels Before and After the Eradication of<i> Helicobacter pylori</i> Infection

Cited by 7 publications

References 34 publications

Association between Helicobacter pylori antibody‐positive status and extragastric diseases in Japanese junior high school students

Association between Helicobacter pylori antibody‐positive status and extragastric diseases in Japanese junior high school students

Prevalence of Autoimmune Gastritis in Individuals Undergoing Medical Checkups in Japan

The Effect of Helicobacter pylori Eradication on Lipid Levels: A Meta-Analysis

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