Influence of the cigarette smoking trend on carboxyhemoglobin levels in banked blood – An update fourteen years later

Meuli, Mercades; Yue, Alexander J.; Swerdloff, Michael; Feustel, Paul J.; Hanakova, Marcela; Ehlers, Melissa

doi:10.1016/j.jclinane.2019.109677

Cited by 2 publications

(2 citation statements)

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“…Normally, COHb concentrations are less than 2%. However, smokers can get up to 14% or higher COHb, though this number is typically below 9% (Goldman, 1977;Mitchell, 1979;Hart et al, 2006;Eichhorn et al, 2018;Meuli et al, 2020;Superv ıa et al, 2021). With such information as the background, target occupancy needs to consider the exchange of CO between a target and Hb.…”

Section: A Bird's-eye View Of the Co Target Collection: Its Landscape...mentioning

confidence: 99%

Carbon Monoxide Signaling: Examining Its Engagement with Various Molecular Targets in the Context of Binding Affinity, Concentration, and Biologic Response

et al. 2022

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Carbon monoxide (CO) has been firmly established as an endogenous signaling molecule with a variety of pathophysiological and pharmacological functions, including immunomodulation, organ protection, and circadian clock regulation, among many others. In terms of its molecular mechanism(s) of action, CO is known to bind to a large number of hemoproteins with at least 25 identified targets, including hemoglobin, myoglobin, neuroglobin, cytochrome c oxidase, cytochrome P450, soluble guanylyl cyclase, myeloperoxidase, and some ion channels with dissociation constant values spanning the range of sub-nM to high lM. Although CO's binding affinity with a large number of targets has been extensively studied and firmly established, there is a pressing need to incorporate such binding information into the analysis of CO's biologic response in the context of affinity and dosage. Especially important is to understand the reservoir role of hemoglobin in CO storage, transport, distribution, and transfer. We critically review the literature and inject a sense of quantitative assessment into our analyses of the various relationships among binding affinity, CO concentration, target occupancy level, and anticipated pharmacological actions. We hope that this review presents a picture of the overall landscape of CO's engagement with various targets, stimulates additional research, and helps to move the CO field in the direction of examining individual targets in the context of all of the targets and the concentration of available CO. We believe that such work will help the further understanding of the relationship of CO concentration and its pathophysiological functions and the eventual development of CO-based therapeutics.-Significance Statement--The further development of carbon monoxide (CO) as a therapeutic agent will significantly rely on the understanding of CO's engagement with therapeutically relevant targets of varying affinity. This review critically examines the literature by quantitatively analyzing the intricate relationships among targets, target affinity for CO, CO level, and the affinity state of carboxyhemoglobin and provide a holistic approach to examining the molecular mechanism(s) of action for CO.

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Section: A Bird's-eye View Of the Co Target Collection: Its Landscape...mentioning

confidence: 99%

Carbon Monoxide Signaling: Examining Its Engagement with Various Molecular Targets in the Context of Binding Affinity, Concentration, and Biologic Response

et al. 2022

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“…Hal ini juga selaras dengan penelitian lainnya yang dilakukan bahwa kebiasaan merokok beruhubungan dengan peningkatan kadar COHb pada darah pedagang kaki lima dan orang yang berisiko di sekitar jalan raya (10,18,20) . Penelitian lain menunjukkan bahwa konsentrasi COHb pada manusia turun disebabkan karena menurunnya perokok pada kelompok masyarakat umum (21) . Sehingga paparan gas CO yang di sebabkan oleh rokok dapat menyebabkan meningkatnya kadar COHb dalam darah seseorang perokok baik itu pasif atau aktif, dan ketika paparan asap rokok menurun dapat menurunkan kadar COHb.…”

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Literature Review: Dampak Paparan Gas Karbon Monoksida Terhadap Kesehatan Masyarakat yang Rentan dan Berisiko Tinggi

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Azizah

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et al. 2022

Jurnal Kesehatan Lingkungan Indonesia

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Latar belakang: Karbon monoksida (CO) merupakan gas yang tidak memiliki warna dan bau, yang dapat membahayakan apabila terhirup dengan jumlah yang besar. Sumber gas CO di udara adalah mobil, truk dan kendaraan lainnya, barang yang ada di rumah seperti pemanas ruangan dengan minyak tanah, cerobong asap, dan tungku yang bocor, kompor gas, asap rokok merupakan benda yang dapat melepaskan gas CO di dalam ruangan.Metode: Penelitian ini merupakan literature Review. Data base yang digunakan dalam pencarian artikel ini dengan menggunakan google scholar dan Science Direct dengan kata kunci “Karbon Monoksida, COHb, Carbon Monoxide, Health Effect” yang telah dilakukan peneliti sebelumnya baik dari dalam ataupun luar negeriHasil: Hasil review artikel di dapatkan beberapa data mengenai penyakit, gejala dan juga efek Kesehatan yang disebabkan oleh paparan gas CO yang terjadi di masyarakat. Paparan gas CO dapat menyebabkan naiknya kadar karboksihemoglobin (COHb) pada darah, sakit kepala, pusing, sesak nafas, mata berair, tekanan darah tinggi. Paparan gas CO dapat menyebabkan bronchitis, penyakit jantung coroner, hipertensi, stroke serta dapat menyebabkan Delayed Encephalopathy After Acute Carbon Monoxide Poisoning (DEACMP). Paparan gas CO berhubungan dengan kejadian BBLR, kejadian stunting pada balita serta menyebabkan peningkatan kasus dan peningkatan angka kematian akibat Covid-19.Simpulan: Paparan gas CO dapat mempengaruhi kondisi Kesehatan manusiaABSTRACTTitle: Literature Review : Impact of Exposure to Carbon Monoxide Gas on Public HealthBackground: Carbon monoxide (CO) is a gas that has no color and odor, which can be harmful if inhaled in large quantities. Sources of CO gas in the air are cars, trucks other vehicles, items in the house such as space heaters with kerosene, leaking chimneys, and stoves, gas stoves, and cigarette smoke are objects that can release CO gas indoor.Method This research is a literature review. Databases used in the search for this article using Google Scholar and Science Direct with the keywords "Carbon Monoxide, COHb, Carbon Monoxide, Health Effect" which previous researchers have carried out both from within and outside the country.Result: The results of the article review obtained some data regarding diseases, symptoms and also health effects caused by exposure to CO gas that occurred in the community. Exposure to CO gas can cause increased levels of carboxyhemoglobin (COHb) in the blood, headaches, dizziness, shortness of breath, watery eyes, high blood pressure. Exposure to CO gas can cause bronchitis, coronary heart disease, hypertension, stroke and can cause Delayed Encephalopathy After Acute Carbon Monoxide Poisoning (DEACMP). Exposure to CO gas is associated with the incidence of LBW, the incidence of stunting in toddlers and causes an increase in cases and an increase in mortality due to Covid-19.Conclusion: CO Exposure can affect human health conditions

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Influence of the cigarette smoking trend on carboxyhemoglobin levels in banked blood – An update fourteen years later

Cited by 2 publications

References 5 publications

Carbon Monoxide Signaling: Examining Its Engagement with Various Molecular Targets in the Context of Binding Affinity, Concentration, and Biologic Response

Carbon Monoxide Signaling: Examining Its Engagement with Various Molecular Targets in the Context of Binding Affinity, Concentration, and Biologic Response

Literature Review: Dampak Paparan Gas Karbon Monoksida Terhadap Kesehatan Masyarakat yang Rentan dan Berisiko Tinggi

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