Influence of the C677T Polymorphism of the<i>MTHFR</i>Gene on Oxidative Stress in Women With Overweight or Obesity: Response to a Dietary Folate Intervention

Ribeiro, Marina Ramalho; Lima, Renally Bezerra Wanderley e; Lisboa, Jéssica Vanessa de Carvalho; Chaves, Thamires Ribeiro; Luna, Rafaella Cristhine Pordeus; Nascimento, Rayner Anderson Ferreira do; Oliveira, Yohanna de; Persuhn, Darlene Camati; Silva, Alexandre; Gonçalves, Maria da Conceição Rodrigues; Ferreira, Flávia Emília Leite de Lima; Lima, Roberto Teixeira de; Diniz, Alcides da Silva; Almeida, Aléssio Tony Cavalcanti de; Moraes, Ronei Marcos de; Verly, Eliseu; Costa, Maria José de Carvalho

doi:10.1080/07315724.2018.1460224

Cited by 13 publications

(13 citation statements)

References 42 publications

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“…Thus, in the present study, folate availability was sufficient to significantly reduce Hcy using supplementation longer than four weeks. The same results were demonstrated in the meta-analysis carried out by Colson et al [64] and confirmed by other studies [3,15,55,56,60,64,76], showing a reduction in inflammatory parameters, and suggesting that one effect is a consequence of the other.…”

Section: Discussionsupporting

confidence: 82%

“…A third R24h was performed after the plateau week to investigate adherence to the nutritional instructions that were given. A fourth R24h was performed at the end of the eight-week intervention to analyze the participants' usual caloric and nutrient intake to establish whether they had adhered to the recommendations and whether changes in their global and folate dietary intake had occurred after the intervention [3].…”

Section: Food Consumptionmentioning

confidence: 99%

“…In addition, another factor contributing to oxidative stress is the high level of homocysteine (Hcy) in the blood. Hcy, a metabolite derived from folate metabolism, may be increased in the presence of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, high Hcy oxidation and body fat accumulation could lead to cytokine-mediated inflammation, and an increase in the oxidative stress. In addition, a balanced diet rich in antioxidants and anti-inflammatory nutrients like folate might be necessary to reduce this damage and also to avoid the C677T polymorphism effects [3,[13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

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Food Intervention with Folate Reduces TNF-α and Interleukin Levels in Overweight and Obese Women with the MTHFR C677T Polymorphism: A Randomized Trial

et al. 2020

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Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism associated with body fat accumulation could possibly trigger an inflammatory process by elevating homocysteine levels and increasing cytokine production, causing several diseases. This study aimed to evaluate the effects of food intervention, and not folate supplements, on the levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β) in overweight and obese women with the MTHFR C677T polymorphism. A randomized, double-blind eight-week clinical trial of 48 overweight and obese women was conducted. Participants were randomly assigned into two groups. They received 300 g of vegetables daily for eight weeks containing different doses of folate: 95 µg/day for Group 1 and 191 µg/day for Group 2. MTHFR C677T polymorphism genotyping was assessed by digestion with HinfI enzyme and on 12% polyacrylamide gels. Anthropometric measurements, 24-h dietary recall, and biochemical analysis (blood folic acid, vitamin B12, homocysteine (Hcy), TNF-α, IL-1β, and IL-6) were determined at the beginning and end of the study. Group 2 had a significant increase in folate intake (p < 0.001) and plasma folic acid (p < 0.05) for individuals with the cytosine–cytosine (CC), cytosine–thymine (CT), and thymine–thymine (TT) genotypes. However, only individuals with the TT genotype presented reduced levels of Hcy, TNF-α, IL-6, and IL-1β (p < 0.001). Group 1 showed significant differences in folate consumption (p < 0.001) and folic acid levels (p < 0.05) for individuals with the CT and TT genotypes. Food intervention with folate from vegetables increased folic acid levels and reduced interleukins, TNF-α, and Hcy levels, mainly for individuals with the TT genotype.

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Section: Discussionsupporting

confidence: 82%

Section: Food Consumptionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Food Intervention with Folate Reduces TNF-α and Interleukin Levels in Overweight and Obese Women with the MTHFR C677T Polymorphism: A Randomized Trial

et al. 2020

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“…MTHFR enzyme is involved in the metabolism of folate and homocysteine (Hcy). This gene is linked with folate metabolism which plays a positive effects on oxidative stress by its protecting action against cell death and increased folic concentrations stabilize MTHFR enzyme [80]. Earlier studies have found the synergetic effect of folic acid on growth, yield, and yield quality of many plant species.…”

Section: Marker Trait Association and Putative Candidate Genes For Anmentioning

confidence: 99%

Uncovering Phenotypic Diversity and DArTseq Marker Loci Associated with Antioxidant Activity in Common Bean

Nadeem

Gündoğdu

Erċışlı

et al. 2019

Genes

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Antioxidants play an important role in animal and plant life owing to their involvement in complex metabolic and signaling mechanisms, hence uncovering the genetic basis associated with antioxidant activity is very important for the development of improved varieties. Here, a total of 182 common bean (Phaseolus vulgaris) landraces and six commercial cultivars collected from 19 provinces of Turkey were evaluated for seed antioxidant activity under four environments and two locations. Antioxidant activity was measured using ABTS radical scavenging capacity and mean antioxidant activity in common bean landraces was 20.03 µmol TE/g. Analysis of variance reflected that genotype by environment interaction was statistically non-significant and heritability analysis showed higher heritability of antioxidant activity. Variations in seed color were observed, and a higher antioxidant activity was present in seeds having colored seed as compared to those having white seeds. A negative correlation was found between white-colored seeds and antioxidant activity. A total of 7900 DArTseq markers were used to explore the population structure that grouped the studied germplasm into two sub-populations on the basis of their geographical origins and trolox equivalent antioxidant capacity contents. Mean linkage disequilibrium (LD) was 54%, and mean Genes 2020, 11, 36 2 of 17 LD decay was 1.15 Mb. Mixed linear model i.e., the Q + K model demonstrated that four DArTseq markers had significant association (p < 0.01) for antioxidant activity. Three of these markers were present on chromosome Pv07, while the fourth marker was located on chromosome Pv03. Among the identified markers, DArT-3369938 marker showed maximum (14.61%) variation. A total of four putative candidate genes were predicted from sequences reflecting homology to identified DArTseq markers. This is a pioneering study involving the identification of association for antioxidant activity in common bean seeds. We envisage that this study will be very helpful for global common bean breeding community in order to develop cultivars with higher antioxidant activity.

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Micronutrients

Chakrabarty¹,

Chakrabarty²

2019

Textbook of Nutrition in Health and Disease

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Influence of the C677T Polymorphism of theMTHFRGene on Oxidative Stress in Women With Overweight or Obesity: Response to a Dietary Folate Intervention

Cited by 13 publications

References 42 publications

Food Intervention with Folate Reduces TNF-α and Interleukin Levels in Overweight and Obese Women with the MTHFR C677T Polymorphism: A Randomized Trial

Food Intervention with Folate Reduces TNF-α and Interleukin Levels in Overweight and Obese Women with the MTHFR C677T Polymorphism: A Randomized Trial

Uncovering Phenotypic Diversity and DArTseq Marker Loci Associated with Antioxidant Activity in Common Bean

Micronutrients

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