Influence of the BRAF V600E Mutation on Expression of Vascular Endothelial Growth Factor in Papillary Thyroid Cancer

Jo, Young Suk; Li, Shengjin; Song, Jung Hun; Kwon, Kui Hyang; Lee, Jun Chul; Rha, So Young; Lee, Hyo Jin; Sul, Ji Young; Kweon, Gi Ryang; Ro, Heung-Kyu; Kim, Jin Man; Shong, Minho

doi:10.1210/jc.2005-2836

Cited by 147 publications

(118 citation statements)

References 20 publications

Supporting

Mentioning

100

Contrasting

Unclassified

Order By: Relevance

“…This response involves chemokines and VEGF-A (Borrello et al, 2008). VEGF-A was identified also in human thyroid cancer samples, where it correlated with tumor aggressiveness (Klein et al, 2001;Jo et al, 2006), and it has been linked to activation of BRAF-ERK signaling also in melanomas (Sumimoto et al, 2006). Interestingly, VEGF-A induces human mast cell chemotaxis by activating VEGFR1 and VEGFR2 (Detoraki et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Mast cells have a protumorigenic role in human thyroid cancer

et al. 2010

View full text Add to dashboard Cite

In different human carcinoma types, mast cell infiltrate increases with respect to normal tissue and mast cell density correlates with a bad prognosis. To assess the role of mast cells in human thyroid cancer, we compared the density of tryptase-positive mast cells in 96 papillary thyroid carcinomas (PTCs) versus normal thyroid tissue from 14 healthy individuals. Mast cell density was higher in 95% of PTCs (n ¼ 91) than in control tissue. Mast cell infiltrate correlated with extrathyroidal extension (P ¼ 0.0005) of PTCs. We show that thyroid cancer cell-line-derived soluble factors induce mast cell activation and chemoattraction in vitro. Different mast cell lines (HMC-1 and LAD2) and primary human lung mast cells induced thyroid cancer cell invasive ability, survival and DNA synthesis in vitro. The latter effect was mainly mediated by three mast-cell-derived mediators: histamine, and chemokines CXCL1/GROa and CXCL10/IP10. We show that xenografts of thyroid carcinoma cells (8505-C) could recruit mast cells injected into the tail vein of mice. Co-injection of human mast cells accelerated the growth of thyroid cancer cell (8505-C) xenografts in athymic mice. This effect was mediated by increased tumor vascularization and proliferation, and was reverted by treating mice with sodium cromoglycate (Cromolyn), a specific mast cell inhibitor. In conclusion, our study data suggest that mast cells are recruited into thyroid carcinomas and promote proliferation, survival and invasive ability of cancer cells, thereby contributing to thyroid carcinoma growth and invasiveness.

show abstract

Section: Discussionmentioning

confidence: 99%

Mast cells have a protumorigenic role in human thyroid cancer

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Following the activation of the MAPK pathway, secondary molecular events occur, such as hypomethylation and genome-wide hypermethylation, which augment the tumorigenic activity of this pathway [52]. In addition, upregulation of several oncogenic proteins, such as chemokines [53,54], nuclear factor B (NF-B) [55], vascular endothelial growth factor A (VEGFA) [56], matrix metalloproteinases (MMPs) [53,55,57], MET [58,59], vimentin [60], prokineticin 1 (PROK1; also known as EG VEGF) [61], prohibitin [62], hypoxia-inducible factor 1␣ (HIF1␣) [63], thrombospondin 1 (TSP1) [64], urokinase plasminogen activator (uPA) and its receptor (uPAR) [65,66] and transforming growth factor ␤1 (TGF␤1) [67,68] drive cancer cell growth, proliferation and survival, together with tumor angiogenesis, invasion and metastasis.…”

Section: The Mapk Signaling Pathwaymentioning

confidence: 99%

An update on molecular biology of thyroid cancers

Ömür

Baran

2014

Critical Reviews in Oncology/Hematology

View full text Add to dashboard Cite

“…In Korea, the incidence of thyroid cancer is also rapidly increasing; the incidence rates per 100,000 persons adjusting for age increased from 2.1 (in 1999) to 15.4 (in 2009) in males and 10.4 (in 1999) to 79.6 (in 2009) in females (23)-rates that are higher than in any other country studied (24). Furthermore, Korean DTCs have several distinguishing characteristics: (i) family history of DTC is twofold higher than in other studies (25), (ii) PTC is more frequent (more than 90%) (26), and (iii) DTC patients had higher rates of BRAF V600E mutations (58-81%) (27)(28)(29) in Korea than in any other country (30). Environmentally, Korea is one of the iodinesufficient areas in the world (31).…”

mentioning

confidence: 95%

Long-Term Prognosis of Differentiated Thyroid Cancer with Lung Metastasis in Korea and Its Prognostic Factors

Cho

Choi²,

Yeom³

et al. 2014

Thyroid

View full text Add to dashboard Cite

Background: Distant metastasis, generally to lung and bone, is rare in differentiated thyroid carcinoma (DTC) and the prognosis is still elusive. We investigated long-term outcomes of lung metastasis in DTC patients and its prognostic factors. Methods: A retrospective review was performed of 4572 patients who underwent surgery for DTC from 1962 to 2009 at Seoul National University Hospital. Among them, 164 patients were identified with lung metastasis and 152 patients were enrolled in the final analysis. Poor prognosis was defined as progressive disease or death. Results: Of these 152 patients, 10-and 20-year survival rates were 85.0% and 71.0%, respectively. No evidence of disease, stable disease, progressive disease, and death was identified in 22.4%, 28.3%, 35.5%, and 13.8%, respectively, after 11 years of median follow-up (range 2-41 years). Older age at diagnosis ( ‡ 45 years), primary tumor size ‡ 2 cm, follicular thyroid cancer, metastasis diagnosed after initial evaluation or 131 I remnant ablation (late metastasis), multiple metastases other than lung, 131 I nonavidity, and the presence of macronodules ( ‡ 1 cm) were more frequent in poor prognoses. Cox proportional hazard ratio for progression-free survival showed that 131 I nonavidity was the only independent predictive factor for poor prognosis. Conclusions: The prognosis of lung metastasis from DTC in Korea within this study was favorable.

show abstract

Influence of the BRAF V600E Mutation on Expression of Vascular Endothelial Growth Factor in Papillary Thyroid Cancer

Cited by 147 publications

References 20 publications

Mast cells have a protumorigenic role in human thyroid cancer

Mast cells have a protumorigenic role in human thyroid cancer

An update on molecular biology of thyroid cancers

Long-Term Prognosis of Differentiated Thyroid Cancer with Lung Metastasis in Korea and Its Prognostic Factors

Contact Info

Product

Resources

About