Influence of the antioxidant quercetin in vivo on the level of nitric oxide determined by electron paramagnetic resonance in rat brain during global ischemia and reperfusion

Shutenko, Zhanna; Henry, Y.; Pinard, Elisabeth; Seylaz, Jacques; Potìer, Pierre; Berthet, Fabienne; Girard, Pierre Marie; Sercombe, Richard

doi:10.1016/s0006-2952(98)00296-2

Cited by 145 publications

(87 citation statements)

References 61 publications

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“…In vivo studies in animals demonstrate protective effects of the flavonoids epicatechin and quercetin against ischemia/reperfusion-induced neuronal injury [86,187]. Furthermore, flavonoids showed protective effects against an increase in brain lipid peroxidation following Vitamin E deprivation [219], attenuated neuronal damage induced by ethanol administration [113,199] and reduced O-ethyl-S,Sdipropyl phosphorodithioate-induced neurotoxicity in mice [163].…”

Section: Flavonoids: Neuroprotective Agents In Vivo and In Vitro?mentioning

confidence: 99%

MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide

Schroeter

Boyd

Spencer

et al. 2002

Neurobiology of Aging

302

178

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Oxidative and nitrosative stress is increasingly associated with the pathology of neurodegeneration and aging. The molecular mechanisms underlying oxidative/nitrosative stress-induced neuronal damage are emerging and appear to involve a mode of death in which mitogen-activated protein kinase (MAPK) signaling pathways are strongly implicated. Thus, attention is turning towards the modulation of intracellular signaling as a therapeutic approach against neurodegeneration. Both endogenous and dietary agents have been suggested as potent modulators of intracellular signal transduction, e.g. nitric oxide and flavonoids, respectively. This review addresses recent findings on the biological effects of flavonoids and nitric oxide in neurodegeneration and aims to elucidate the rationale for their prospective use as modulators of cellular signal transduction. © 2002 Elsevier Science Inc. All rights reserved.Keywords: Apoptosis; Oxidative stress; Neuron; Flavonoids; MAP kinase; JNK; ERK; Epicatechin; Nitric oxide; Mitochondria; Redox status; Polyphenols Abbreviations: AKT, serine/threonine kinase (also known as protein kinase B); AP-1, activator protein-1; Apaf-1, apoptosis protease activating factor-1; ASK1, apoptosis signal-regulating kinase-1; Bad, Bcl-2/BclX Lassociated death promoting protein; Bax, pro-apoptotic protein of the Bcl-2 family; Bcl-2, B-cell lymphoma 2: protein with anti-apoptotic properties; BclX L , long form of Bclx: anti-apoptotic protein of the Bcl-2 family; Caspase, cysteinyl aspartic acid-protease; c-Jun, mammalian equivalent of Jun: part of the AP-1 transcription complex; CREB, cAMP response element binding protein; DIABLO/smac, mitochondria-related pro-apoptotic protein: inhibits XIAP; ERK1/2, extracellular signal-related kinase; Fas, CD95: member of the TNF receptor family; GSHST, glutathione Stransferase; JNK, c-Jun amino-terminal kinase; MAPK, mitogen-activated protein kinase; MAPKK, MAPK kinase; MAPKKK, MAPKK kinase; MEK1/2, ERK1/2-specific MAPKK; MKK4/7, JNK-specific MAPKK; MSK1, mitogen-and stress-activated kinase-1; NF-B, nuclear factor of immunoglobulin k locus in B-cells; ONOO − , peroxynitrite anion; p53, pro-apoptotic tumor suppressor gene product; PI3-kinase, phosphoinositol 3-kinase; Ras, small G-protein; RNS, reactive nitrogen species; ROS, reactive oxygen species; RSK, pp90 ribosomal S6 kinase; SAPK, stressactivated protein kinase; XIAP, X-linked inhibitor of apoptosis: inhibits the activation of caspase-9

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Section: Flavonoids: Neuroprotective Agents In Vivo and In Vitro?mentioning

confidence: 99%

MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide

Schroeter

Boyd

Spencer

et al. 2002

Neurobiology of Aging

302

178

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“…Since¯avonoids are effective antioxidants, it is plausible that they provide protection against CVA (Shutenko et al, 1999). One prospective study based on a small male cohort reported an inverse association between¯avonoid intake and stroke (Keli et al, 1996), however the evidence from human studies is still scarce.…”

Section: Introductionmentioning

confidence: 99%

Quercetin intake and the incidence of cerebrovascular disease

et al. 2000

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Objective: To study the relation between intake of the antioxidant¯avonoid quercetin and subsequent incidence of cerebrovascular disease (CVA). Design: A cohort study carried out among 9208 Finnish men and women 15 y or more of age and initially free from cardiovascular disease. During a 28 y follow-up period in 1967 ± 1994, a total of 824 cases with CVA were diagnosed. Methods: Food consumption data were collected using a dietary history interview method covering the total habitual diet during the previous year. Results: Quercetin intake was not associated with CVA incidence. The relative risk of CVA adjusted for age, serum cholesterol, body mass index, smoking, hypertension, diabetes, geographical area, occupation and intake of beta-carotene, vitamin E, vitamin C, ®bre, various fatty acids, and energy between the highest and lowest quartiles of quercetin intake was 0.99 (95% con®dence interval (CI) 0.71 ± 1.38) for men and 0.85 (CI 0.60 ± 1.21) for women. In contrast, apples, the major source of quercetin in the study population, showed a signi®cant inverse association both in men and women, mainly due to an association with thrombotic or embolic stroke. The relative risks of thrombotic stroke after further adjustment for quercetin intake were 0.59 (CI 0.35 ± 0.99; P 0.45) and 0.61 (CI 0.33 ± 1.12: P for trend 0.02) for men and women, respectively. Conclusions: The results suggest that the intake of apples is related to a decreased risk of thrombotic stroke. This association apparently is not due to the presence of the antioxidant¯avonoid quercetin.

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“…Peroxynitrite can directly oxidize LDLs resulting in irreversible damage to cell membranes. Quercetin causes scavenging of free radicals; therefore can no longer react with nitric oxide, resulting in less damage 21 . Nitric oxide interestingly can be viewed as radical itself and can directly be scavenged by Flavonoids…”

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confidence: 99%

Quercetin: A Versatile Flavonoid

Lakhanpal

Kumar²

2007

Internet Journal of Medical Update - EJOURNAL

210

198

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Associative evidence from observational and intervention studies in human subjects shows that a diet including plant foods (particularly fruit and vegetables rich in antioxidants) conveys health benefits. There is no evidence that any particular nutrient or class of bioactive substances makes a special contribution to these benefits. Flavonoids occur naturally in fruits, vegetables and beverages such as tea and wine. Quercetin is the major flavonoid which belongs to the class called flavonols. Quercetin is found in many common foods including apples, tea, onions, nuts, berries, cauliflower, cabbage and many other foods. Quercetin provides many health promoting benefits, including improvement of cardiovascular health, eye diseases, allergic disorders, arthritis, reducing risk for cancers and many more. The main aim of this review is to obtain a further understanding of the reported beneficial health effects of Quercetin, its pharmacological effects, clinical application and also to evaluate its safety.

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Influence of the antioxidant quercetin in vivo on the level of nitric oxide determined by electron paramagnetic resonance in rat brain during global ischemia and reperfusion

Cited by 145 publications

References 61 publications

MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide

MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide

Quercetin intake and the incidence of cerebrovascular disease

Quercetin: A Versatile Flavonoid

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