Influence of the amount of platelet-bound IgG on platelet survival and site of sequestration in autoimmune thrombocytopenia

Kernoff, L. M.; Blake, K.C.H.; Shackleton, D.

doi:10.1182/blood.v55.5.730.730

Cited by 79 publications

(13 citation statements)

References 13 publications

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“…Finally, the value of the labelled platelets sequestration site has been questioned by studies suggesting that this sequestration site was mainly determined by the amount of PAIgG, and could vary in individual patients with the course and severity of the disease (26, 27). Correlations were seen between a very short platelet survival, a high level of PAIgG and hepatic sequestration (26,27). In our patients, however, we could not find these correlations.…”

Section: Discussioncontrasting

confidence: 81%

Reevaluation of the prognostic factors for splenectomy in chronic idiopathic thrombocytopenic purpura (ITP): A report on 181 cases

Fenaux

Caulier

Hirschauer

et al. 1989

European J of Haematology

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From 1973 to 1986 we splenectomized 181 patients with chronic ITP after platelet kinetic studies with 51Cr or 111In. Mean age at diagnosis was 34 (range 4–79 yr). Follow‐up of at least 1 yr after splenectomy was available in every patient. 141 patients (78%) achieved remission (platelets > 100 times 109/1 by 3 months after splenectomy), of whom 9 subsequently relapsed. Among the 40 non‐responders at 3 months, 3 achieved a later remission spontaneously. Factors associated with response to splenectomy included a high post‐operative platelet count (p = 0.0001), younger age at the time of surgery (p = 0.0077) and predominantly splenic sequestration of platelets (p = 0.0002), the two latter factors being partially correlated. In a multivariate analysis, however, only post‐operative platelet count and age retained an independent prognostic significance, whereas the sequestration site of platelets had only borderline value. These results are discussed in the context of indications of platelet kinetic studies in chronic ITP, before splenectomy is considered.

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Section: Discussioncontrasting

confidence: 81%

Reevaluation of the prognostic factors for splenectomy in chronic idiopathic thrombocytopenic purpura (ITP): A report on 181 cases

Fenaux

Caulier

Hirschauer

et al. 1989

European J of Haematology

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“…greater than 4 times normal, probably had a poor prognosis to conventional therapy with steroids and/or splenectomy. Kernoff et al (1980) showed a correlation between PAIgG levels and sites of platelet sequestration and Mueller-Ekhardt et a Z (1982) suggested that only 10% of the elevated PAIgG determined immune destruction of plateIets. The majority of our patients with levels of PAIgG greater than 4 times the upper limit of normality were found to have particularly high PAIgM values.…”

Section: Discussionmentioning

confidence: 99%

Platelet associated immunoglobulins (PAIgG and PAIgM) in autoimmune thrombocytopenia

et al. 1985

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An enzyme linked assay system was used to quantitate platelet associated IgM (PAIgM) in addition to platelet associated IgG (PAIgG) in normal subjects and in 145 patients with autoimmune thrombocytopenia (AITP). The mean PAIgM level in normals was 1.17 ng/10(6) platelets with a range of 0.01-2.45 ng (mean +/- 2 SD). The corresponding PAIgG values as follows: mean 6.0 ng, range 2.0-10 ng/10(6) platelets. Elevated PAIgG was seen in 67.6% and abnormally raised PAIgM in 79.3% of patients. Both values were raised together in 57.2% and either elevated PAIgG or PAIgM in 89.7%. All patients with PAIgG values greater than 4 times upper limit of normality were found to have abnormal PAIgM. The relevance of elevated PAIgM, the possible interaction between PAIgG and PAIgM and the implication of our results in patients with autoimmune thrombocytopenia are discussed.

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“…Likewise, elevated PAIg may contribute to the abnormal haemostasis in myelofibrosis patients (20,21). Furthermore, increased amounts of PAIg may accelerate the sequestration of platelets in the spleen and liver, thus contributing to the thrombocytopenia in these patients (22).…”

Section: Discussionmentioning

confidence: 99%

Platelet‐associated IgG and IgM in myelofibrosis

Hasselbalch

Berild

Hansen

1984

Scandinavian Journal of Haematology

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Elevated levels of platelet‐associated IgG and/or IgM were found in 15 of 18 patients with myelofibrosis (83 %). All but 5 patients with elevated PAIg had active disease. The amounts of PAIg were not correlated to either S‐Ig, platelet count or spleen size. Levels of PAIgG well above the normal range were especially found in patients with short duration of disease and/or a transitional myeloproliferative state. It is debated whether immune‐mediated platelet dysfunction may be of importance for the development of bone marrow fibrosis, mediated by the release of platelet‐derived growth factors in the bone marrow. Elevated PAIg may also contribute to abnormal haemostasis and thrombocytopenia in myelofibrosis.

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Influence of the amount of platelet-bound IgG on platelet survival and site of sequestration in autoimmune thrombocytopenia

Cited by 79 publications

References 13 publications

Reevaluation of the prognostic factors for splenectomy in chronic idiopathic thrombocytopenic purpura (ITP): A report on 181 cases

Reevaluation of the prognostic factors for splenectomy in chronic idiopathic thrombocytopenic purpura (ITP): A report on 181 cases

Platelet associated immunoglobulins (PAIgG and PAIgM) in autoimmune thrombocytopenia

Platelet‐associated IgG and IgM in myelofibrosis

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