Influence of the Agonal Period on the Postmortem Metabolic State of the Heart

Lundsgaard-Hansen, P; Schilt, W; Heitmann, L.; Oroz, Maja; A, Büchler; Lemeunier, A

doi:10.1097/00000658-197111000-00003

Cited by 17 publications

(5 citation statements)

References 22 publications

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“…In several successful animal experiments, investigators used either exsanguination 8,15,16 or asphyxiation 6,7,17 as the mode of death. 9 yet maintains a better myocardial metabolic state than asphyxiation, 10 it was used in several previous animal experiments and some investigators have reported their results as "successful" DCD heart transplantation. 8,15,16 To resolve this issue, an exsanguinated DCD model was chosen as one of the groups in this study and was compared with an asphyxiated group that was considered as "realistic" for clinical DCD donors.…”

Section: Discussionmentioning

confidence: 99%

Circulatory Load During Hypoxia Impairs Post-transplant Myocardial Functional Recovery in Donation After Cardiac Death

Osaki

Ishino

Kotani

et al. 2009

The Journal of Heart and Lung Transplantation

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Section: Discussionmentioning

confidence: 99%

Circulatory Load During Hypoxia Impairs Post-transplant Myocardial Functional Recovery in Donation After Cardiac Death

Osaki

Ishino

Kotani

et al. 2009

The Journal of Heart and Lung Transplantation

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“…The myocardium of agonally arrested hearts is damaged by hypoxia during ante mortem shock [13], anoxia during asphyxia [12], and warm ischemia from the moment of cardiac arrest until the start of preserva tion [10][11][12][13][14][15]. To utilize an asphyxiated ca daver heart as a donor organ following pro longed preservation, the five causative fac tors of myocardial cell damage, as shown in table 5, must be addressed.…”

Section: Discussionmentioning

confidence: 99%

Prolonged Preservation of Cadaver Heart with Belzer UW Solution: 24-Hour Storage System for Asphyxiated Canine Hearts

Shirakura¹,

Nakata²,

Kaneko³

et al. 1990

Eur Surg Res

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The efficacy of Belzer UW solution was compared to Collins’ solution in the preservation of asphyxiated cadaver hearts in a canine model. Donor hearts were stored for 24 h: 2 h of in situ hypothermic (15 °C) coronary perfusion plus 22 h of simple immersion in ice-cold solution. Verapamil, propranolol and prostacyclin were used for myocytoprotection in both groups. After orthotopic transplantation, all animals were weaned off bypass without inotropic support. After 1 h, however, the cardiac output was significantly higher in the Belzer UW solution group (128 ± 28 vs. 67 ± 13 ml/kg/min, p < 0.01).

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“…Additionally, there is some evidence that death from asphyxiation causes more myocardial damage than death from exsanguination. 48,59 An alternative to the hypoxic pulmonary arrest DCD model is to achieve organ hypoperfusion through a combined pharmacological and technical approach to decrease mean arterial pressure. 30,50 Although such alternative models are very reliable and reproducible, they do not account for the effect of hypoxia, specifically hypoxic pulmonary vasoconstriction, on the physiologic changes in thoracic organs during the agonal period.…”

Section: Donation After Circulatory Deathmentioning

confidence: 99%

“…However, this mode of death does not reflect a real clinical DCD situation. Additionally, there is some evidence that death from asphyxiation causes more myocardial damage than death from exsanguination 48,59 …”

Section: Alternative Animal Modelsmentioning

confidence: 99%

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Considerations for the use of porcine organ donation models in preclinical organ donor intervention research

Heinis,

Merani,

Markin

et al. 2024

Anim Models and Exp Med

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Use of animal models in preclinical transplant research is essential to the optimization of human allografts for clinical transplantation. Animal models of organ donation and preservation help to advance and improve technical elements of solid organ recovery and facilitate research of ischemia–reperfusion injury, organ preservation strategies, and future donor‐based interventions. Important considerations include cost, public opinion regarding the conduct of animal research, translational value, and relevance of the animal model for clinical practice. We present an overview of two porcine models of organ donation: donation following brain death (DBD) and donation following circulatory death (DCD). The cardiovascular anatomy and physiology of pigs closely resembles those of humans, making this species the most appropriate for pre‐clinical research. Pigs are also considered a potential source of organs for human heart and kidney xenotransplantation. It is imperative to minimize animal loss during procedures that are surgically complex. We present our experience with these models and describe in detail the use cases, procedural approach, challenges, alternatives, and limitations of each model.

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Influence of the Agonal Period on the Postmortem Metabolic State of the Heart

Cited by 17 publications

References 22 publications

Circulatory Load During Hypoxia Impairs Post-transplant Myocardial Functional Recovery in Donation After Cardiac Death

Circulatory Load During Hypoxia Impairs Post-transplant Myocardial Functional Recovery in Donation After Cardiac Death

Prolonged Preservation of Cadaver Heart with Belzer UW Solution: 24-Hour Storage System for Asphyxiated Canine Hearts

Considerations for the use of porcine organ donation models in preclinical organ donor intervention research

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